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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
2,413,364 |
165,241 |
| US |
764,053 |
40,707 |
Apologies: Because of a software glitch, you received two incomplete copies of yesterdays newsletter. Here is the corrected version./b>
Peer Review, The Press, and Seroprevalence Misinformation Three recent studies seem to be delivering startling information about the prevalence of antibodies to SARS-CoV-2 and the percent of infections that are asymptomatic, but they may be telling us more about the flaws inherent in the release of studies in the absence of peer review.
Research News
Three large collaborative studies include a catalog of potential interactions between the virus and human cells, a system for pooling patient results from 5 countries, and a study of the virus in aerosols. A study points to the impact of Covid-19 on other causes of death and three meta-analyses deliver sobering news about the lack of effective treatment alternatives
- A major collaborative effort** injected all known viral proteins into cell cultures and found protein:protein interactions with 332 human proteins, which include potential targets for 69 existing FDA-approved drugs.
- A study of non-Covid-19 deaths in England and Wales** shows an increase in week 14 of 2020, four weeks after the first Covid-19 death. These are early stage results, but they demonstrate that the public health impact of the disease extends beyond the direct impact of the disease.
- An unprecedented collaboration among 96 hospitals in five countries** to coordinate medical records creates a data set that can be used to study the clinical course of almost 30,000 Covid-19 patients. The authors present an initial analysis describing the clinical characteristics of the disease with high precision.
- A new study of SARS-CoV-2 in aerosols** finds that the virus may remain infective for far longer than previously believed, up to 16 hours.
- A cohort of 56 patients shed the SARS-CoV-2 virus for up to five weeks following their first positive test.
- Meta-analyses of Chloroquine** antibiotics in children** and antivirals in children** find little evidence of efficacy for any of these as a treatment for Covid-19.
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*Preprint **Not peer reviewed.
- Covid19- Ahead of the Curve.
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Top News
- Has mortality due to other causes increased during the Covid-19 pandemic? Early evidence from England and Wales MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing Outbreak Science, April 19, 2020
- International Electronic Health Record-Derived COVID-19 Clinical Course Profile: The 4CE Consortium MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
Virology, Immunology, and Pathophysiology
- Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
- SARS‐CoV‐2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup Wiley: Coronavirus Research & News, April 18, 2020
- Laboratory testing of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 (2019‐nCoV): Current status, challenges, and countermeasures Wiley: Coronavirus Research & News, April 18, 2020
Infection Control
- A Validation Study for the Successful Isolation Policy in China: a Meta-Analysis in COVID-19 MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- Suppression of COVID-19 outbreak in the municipality of Vo, Italy MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
- Policing the Coronavirus Outbreak: Processes and Prospects for Collective Disorder Oxford Academic Journals: Coronavirus, April 19, 2020
Clinical
- Piloting Forensic Tele-Mental Health Evaluations of Asylum Seekers MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- Impact of healthcare worker shift scheduling on workforce preservation during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- Lack of coordination and medical disinformation in Canadian self-assessment tools for COVID-19 MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
Epidemiology
- An interim review of the epidemiological characteristics of 2019 novel coronavirus. NIH: National Library of Medicine: Coronavirus, April 18, 2020
- What influences COVID-19 infection rates: A statistical approach to identify promising factors applied to infection data from Germany MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
- Effects on lung, immune function offer warning for drinking in crisis Wiley: Coronavirus Research & News, April 18, 2020
Modeling and Prediction
- Modelling strategies to predict hospital demand during the COVID-19 outbreak in Bogotá, Colombia MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
- A Heuristic Model for Spreading of COVID 19 in Singapore MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
- Modeling COVID-19 latent prevalence to assess a public health intervention at a state and regional scale MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
Review and Commentary
- The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. NIH: National Library of Medicine: Coronavirus, April 19, 2020
- Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). NIH: National Library of Medicine: Coronavirus, April 19, 2020
- World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). NIH: National Library of Medicine: Coronavirus, April 19, 2020
Mental Health
- Amid COVID‐19, self‐care as important for providers as it is for patients Wiley: Coronavirus Research & News, April 18, 2020
- For nonprofits, survival means being proactive, creative in pandemic wake Wiley: Coronavirus Research & News, April 18, 2020
- NAMI New Hampshire maintaining community connectedness Wiley: Coronavirus Research & News, April 18, 2020
Basic Science
- Electronic Structure Benchmark Calculations of CO2 Fixing Elementary Chemical Steps in RuBisCO Using the Projector-Based Embedding Approach ChemRxiv, April 20, 2020
- Gold-Catalyzed Spirocyclization Reactions of N-Propargyl Tryptamines and Tryptophans in Aqueous Media ChemRxiv, April 20, 2020
- Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid, Mild and Practical Way to Access Functionalised Orthoesters ChemRxiv, April 20, 2020
Other
- The Impact of the Covid‐19 Pandemic on Current Anatomy Education and Future Careers: A Student’s Perspective Wiley: Coronavirus Research & News, April 18, 2020
- A Preliminary Assessment of Novel Coronavirus (COVID-19) Knowledge and Perceptions in Nigeria MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- Health Education for Parents During the COVID-19 Outbreak Public Health Education for Parents During the Outbreak of COVID-19: A Rapid Review MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- A consideration of publication-derived immune-related associations in Coronavirus and related lung damaging diseases MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- The impact of early scientific literature in response to COVID-19: a scientometric perspective MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- Assessment of the quality of systematic reviews on COVID‐19: A comparative study of previous coronavirus outbreaks Wiley: Coronavirus Research & News, April 18, 2020
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Coronavirus Research Resources
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China
- A Validation Study for the Successful Isolation Policy in China: a Meta-Analysis in COVID-19 MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- Significantly longer Covid-19 incubation times for the elderly, from a case study of 136 patients throughout China MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- Unapproved Chinese coronavirus antibody tests being used in at least 2 states NBC News: Coronavirus Latest News, April 19, 2020
Iran
- Trump Would Be Willing to Give Coronavirus Aid to Iran if Asked New York Times: Coronavirus, April 19, 2020
- TEHRAN, Iran (AP) — Iran on Monday began opening intercity highways and major shopping centers to stimulate its sanctions-choked economy, gambling that it has brought under control its coronavirus... AP Health News: Coronavirus, April 20, 2020
South Korea
- SEOUL, South Korea (AP) — South Korea reported fewer than 10 new coronavirus cases Sunday for the first time in two months as U.S. governors ease lockdowns amid pressure worldwide from businesses... AP Health News: Coronavirus, April 19, 2020
- BANGKOK (AP) — South Korea on Sunday reported eight more cases of the coronavirus, the first time a daily increase has dropped to a single digit in about two months. AP Health News: Coronavirus, April 19, 2020
- BANGKOK (AP) — South Korea reported just eight more cases of the coronavirus on Sunday, the first time a daily increase has dropped to single digits in about two months. AP Health News: Coronavirus, April 19, 2020
Italy
- SARS-Cov-2 RNA Found on Particulate Matter of Bergamo in Northern Italy: First Preliminary Evidence MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- Suppression of COVID-19 outbreak in the municipality of Vo, Italy MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
- Italy's Daily Coronavirus Death Toll Lowest Since April 12 New York Times: Coronavirus, April 18, 2020
Spain
- PAMPLONA, Spain (AP) — As Spain hunkers down after five weeks of confinement, the brave few keep the country going during a coronavirus outbreak that has killed more than 20,000 of their fellow... AP Health News: Coronavirus, April 19, 2020
- Countries worldwide are wrestling with when and how to ease the restrictions meant to slow the spread of the coronavirus amid rising unemployment. Spain, which imposed one of the strictest... AP Health News: Coronavirus, April 18, 2020
- In Spain, a Call to ‘Free Our Children’ From Coronavirus Confinement New York Times: Coronavirus, April 18, 2020
Germany
- With Broad, Random Tests for Antibodies, Germany Seeks Path Out of Lockdown New York Times: Coronavirus, April 18, 2020
- What influences COVID-19 infection rates: A statistical approach to identify promising factors applied to infection data from Germany MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
- Merkel Scorns 'Discussion Orgies' as German Shops Reopen New York Times: Coronavirus, April 20, 2020
France
- AMMERSCHWIR, France (AP) — Some were born in this warren of small rooms in what used to be a hospital, dating to the 17th century. Many are likely to die here. And all are currently confined to... AP Health News: Coronavirus, April 19, 2020
- PARIS (AP) — The French navy is investigating how the coronavirus infected more than 1,000 sailors aboard the aircraft carrier Charles de Gaulle, amid growing pressure on government leaders to... AP Health News: Coronavirus, April 17, 2020
- French PM Says Coronavirus Situation Improving, but Crisis Not Over New York Times: Coronavirus, April 19, 2020
United Kingdom
- Has mortality due to other causes increased during the Covid-19 pandemic? Early evidence from England and Wales MedRxiv Server for Health Sciences: Coronavirus, April 19, 2020
- British costume designers make scrubs for coronavirus 'superheroes' NBC News: Coronavirus Latest News, April 19, 2020
- British and Irish journalists mark a year since Lyra McKee murder The Guardian (U.K.) - Opinions: Coronavirus, April 19, 2020
- PORTLAND, Maine (AP) — A look at developments around New England related to the coronavirus pandemic: AP Health News: Coronavirus, April 18, 2020
- Letter: Transmission of COVID-19 During Neurosurgical Procedures—Some Thoughts From the United Kingdom Oxford Academic Journals: Coronavirus, April 18, 2020
- English Premier League clubs on Friday discussed the coronavirus testing required and scenarios that could allow the season to resume from June at the earliest, with the aim of completing all... AP Health News: Coronavirus, April 17, 2020
Other International News
- Asia Today: Fewer sick in S Korea, infections rise in Japan AP Health News: Coronavirus, April 19, 2020
- A Heuristic Model for Spreading of COVID 19 in Singapore MedRxiv Server for Health Sciences: Coronavirus, April 18, 2020
- Mexico's Registers 7,497 Confirmed Coronavirus Cases, 650 Deaths New York Times: Coronavirus, April 18, 2020
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Business and Economic News
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Business News
- Policing the Coronavirus Outbreak: Processes and Prospects for Collective Disorder Oxford Academic Journals: Coronavirus, April 19, 2020
- World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). NIH: National Library of Medicine: Coronavirus, April 19, 2020
- Navajo doctor caring for coronavirus patients endures crisis at home: no running water NBC News: Coronavirus Latest News, April 19, 2020
Economics Blogs
- The impact of the coronavirus pandemic on gender equality VoxEU.org, April 19, 2020
- THE BIG LIE: Did COVID-19 Mitigation Save Two Million Lives? Economic Policy Journal, April 19, 2020
- COVID-19 Could Change Travel Behavior Forever... Putting 3 Million b/d Oil Demand At Risk Zero Hedge, April 18, 2020
Top Economics News
- Coronavirus: Future connectivity 'vital for economic recovery' - BBC News (Brexit Economy News), April 19, 2020
- Brazil digging large-scale graves ahead of coronavirus peak - One News Page (Brazilian Economy), April 19, 2020
- How did Britain get its response to coronavirus so wrong? - The Guardian (Brexit Economy News), April 19, 2020
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Law Technology
- Isolation and covid-19: ‘Will I be trapped in my house for what seems like forever?’ - The Washington Post (Law Library), April 18, 2020
- Finding Africa’s path: Shaping bold solutions to save lives and livelihoods in the COVID-19 crisis McKinsey Insights & Publications, April 18, 2020
- Survey: Korean consumer sentiment during the coronavirus crisis McKinsey Insights & Publications, April 18, 2020
Legal Administrator
- COVID-19 and Novel Legal Issues - Gibson Dunn's Randy Mastro Takes a Look at Litigation Law and More, April 18, 2020
- U.S. Department of Labor Issues Alert to Help Keep Manufacturing Workers Safe During Coronavirus Pandemic OSHA News Releases, April 17, 2020
- U.S. Department of Labor Considers Employer’s Good Faith Efforts When Enforcing Compliance During Coronavirus Pandemic OSHA News Releases, April 17, 2020
Librarian News
- Lawyer for Louisiana pastor who defiantly held church service has coronavirus House of Butter, April 19, 2020
- Texas Lawyer Article: The Effects of COVID-19 on Texan Lawyers and Insurers House of Butter, April 19, 2020
- Jacinda Ardern is sued over coronavirus lockdown and is accused of imposing strict measures in New Zealand ‘for her political gain’ House of Butter, April 19, 2020
Leading Law Departments
- Force Majeure and Frustration in English Law M&A Agreements in the Context of COVID-19 General Counsel News, April 19, 2020
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 | | Robert Morris, M.D., Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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