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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
3,219,485 |
228,201 |
| US |
1,064,194 |
61,656 |
Data from worldmeters.info NOTE: Counts for the previous two issues were incorrect because of errors in the CoronavirusDashboard.
What Do the New York Antibody Data Really Mean? A deeply flawed study asserts 20% of New Yorkers have been infected. Once again, the rush to release results has produced more confusion than understanding. At this critical moment, confusion is the enemy.
Research News
SUMMARY
- The first in-depth characterization** of the host transcriptional response to SARS-CoV-2 suggests that the virus elicits a less robust response than influenza A and RSV, which may help explain its unique clinical course and suggests interventions to explore for treatment.
- A comparison of ten commercially available antibody assays** demonstrates substantial variability in test performance and suggests the need for both thorough evaluation of available tests and caution in their use.
- Harvard researchers** describe a reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) assay to detect SARS-CoV-2 that uses readily available reagents and, they assert, is simple, inexpensive, and rapid.
- A detailed contact tracing study from Taiwan finds that only 11 out of 682 close contacts of three cases tested positive for SARS-CoV2, suggesting that the transmission rate to close contacts was less than 2%. The authors do not explore the reasons for this low rate.
- A large, Israeli healthcare organization** developed an extremely sensitive model for identifying high risk intervals using their own tools and experience, on the front lines, in the "fog of war".
- Of 207 consecutive COVID-19 patients in the Stanford hospitals** 35% had gastrointestinal symptoms and that subgroup tended to have more severe disease. This adds to the growing literature indicating that this disease involves many organ systems and suggests GI involvement may be an indicator of increased risk.
* * * * *
*Preprint **Not peer reviewed.
- Covid19- Ahead of the Curve.
* * * * *
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Top News
- SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems Outbreak Science, April 29, 2020
- Test performance evaluation of SARS-CoV-2 serological assays MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- SARS-CoV-2 Detection Using an Isothermal Amplification Reaction and a Rapid, Inexpensive Protocol for Sample Inactivation and Purification MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
- Three Taiwan's domestic family cluster infections of coronavirus disease 2019 Wiley: Coronavirus Research & News, April 29, 2020
- Performing risk stratification for COVID-19 when individual level data is not available, the experience of a large healthcare organization MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
- Association of Digestive Symptoms and Hospitalization in Patients with SARS-CoV-2 Infection MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
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Diagnosis
- Scalable and Resilient SARS-CoV-2 testing in an Academic Centre MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
Infection Control
- Scalable In-hospital Decontamination of N95 Filtering Facepiece Respirator with a Peracetic Acid Room Disinfection System MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
- Negative-Pressure Aerosol Cover for COVID-19 Tracheostomy JAMA Network: Coronavirus, April 28, 2020
- Pediatric Microlaryngoscopy and Bronchoscopy in the COVID-19 Era JAMA Network: Coronavirus, April 28, 2020
Medical Therapy
- Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
- The effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on death and severity of disease in patients with coronavirus disease 2019 (COVID-19): A meta-analysis MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
- Identification of FDA Approved Drugs Targeting COVID-19 Virus by Structure-Based Drug Repositioning ChemRxiv, April 28, 2020
- Possibility of HIV-1 Protease Inhibitors-Clinical Trial Drugs as Repurposed Drugs for SARSCoV-2 Main Protease: A Molecular Docking, Molecular Dynamics and Binding Free Energy Simulation Study ChemRxiv, April 28, 2020
- A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
ICU Care
- Analysis of national and international guidelines on respiratory protection equipment for COVID-19 in healthcare settings. MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
Clinical Course and Outcomes
- Liver Chemistries in Patients with Severe or Non-Severe COVID-19: a Meta-Analysis MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Tracheotomy in the SARS‐CoV‐2 Pandemic Wiley: Coronavirus Research & News, April 29, 2020
- Letter to the Editor: Lipemic serum in patients with COVID‐19 undergoing treatment Wiley: Coronavirus Research & News, April 29, 2020
Impact on Other Specialties
- Is the use of laparoscopy in a COVID‐19 epidemic free of risk? Wiley: Coronavirus Research & News, April 29, 2020
- Optimizing your telemedicine visit during the COVID‐19 pandemic: Practice guidelines for patients with head and neck cancer Wiley: Coronavirus Research & News, April 29, 2020
- Salivary gland disease in the era of COVID‐19 pandemic Wiley: Coronavirus Research & News, April 29, 2020
Reviews, Commentary, and Miscellaneous
- A Novel Plan to Deal with SARS‐CoV‐2 and COVID‐19 Disease Wiley: Coronavirus Research & News, April 29, 2020
- After the pandemic: Medium‐term growth uncertainties Wiley: Coronavirus Research & News, April 29, 2020
- Coercion or the social contract? COVID 19 and spatial (in)justice in African cities Wiley: Coronavirus Research & News, April 29, 2020
Newly Registered Clinical Trials
- Clinical Trial of Allogeneic Mesenchymal Cells From Umbilical Cord Tissue in Patients With COVID-19 April 28, 2020
- OUTpatient Treatment of COVID-19 in Patients With Risk Factor for Poor Outcome April 28, 2020
- Hydroxychloroquine Azithromycin COVID-19 Pregnancy Trial April 28, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis Outbreak Science, April 28, 2020
- Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19 Oxford Academic Journals: Coronavirus, April 28, 2020
Vaccine Development
- The Importance Of Naturally Attenuated Sars‐Cov‐2 In The Fight Against Covid‐19 Wiley: Coronavirus Research & News, April 29, 2020
Epidemiology
- COVID-19 Growth Rate Decreases with Social Capital MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable Analysis MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Estimation of COVID-19 spread curves integrating global data and borrowing information MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- The closer to the Europe Union headquarters, the higher risk of COVID-19? Cautions regarding ecological studies of COVID-19 MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Association between regional selenium status and reported outcome of COVID-19 cases in China Oxford Academic Journals: Coronavirus, April 28, 2020
- SARS-CoV-2 RNA titers in wastewater anticipated COVID-19 occurrence in a low prevalence area MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
Modeling and Prediction
- Instantaneous R calculation for COVID-19 epidemic in Brazil MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- An age-structured epidemiological model of the Belgian COVID-19 epidemic MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Modeling the COVID-19 pandemic - parameter identification and reliability of predictions MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
Public Health Intervention
- Preparing for the unseen threat of infectious disease Wiley: Coronavirus Research & News, April 29, 2020
- Adaptive cyclic exit strategies from lockdown to suppress COVID-19 and allow economic activity MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
- Predictors of adherence to public health instructions during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, April 28, 2020
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Coronavirus Research Resources
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China
- Trump admin asks intel agencies to find out whether China, WHO hid info on coronavirus NBC News: Coronavirus Latest News, April 29, 2020
- KAMPALA, Uganda (AP) — African leaders are asking what China can do for them as the coronavirus pandemic threatens to destroy economies and wipe out some 20 million jobs across a continent where... AP Health News: Coronavirus, April 29, 2020
- BEIJING (AP) — China's delayed Congress to convene next month in sign of confidence country has largely overcome coronavirus outbreak. AP Health News: Coronavirus, April 29, 2020
- Mainland China Reports 22 New Coronavirus Cases vs 6 a Day Earlier New York Times: Coronavirus, April 28, 2020
- Association between regional selenium status and reported outcome of COVID-19 cases in China Oxford Academic Journals: Coronavirus, April 28, 2020
- Chinese Song Expressing Friendship During Pandemic Backfires With Wary Filipinos NPR: Health, April 28, 2020
Iran
- Big Powers Urged to Freeze Sanctions on Syria, Iran, Venezuela During Virus New York Times: Coronavirus, April 28, 2020
Italy
- ROME (AP) — Every October, on the feast day of the patron saint of physicians, Dr. Roberto Stella would organize a simple ceremony at a tiny church in northern Italy to honor Italian doctors who... AP Health News: Coronavirus, April 29, 2020
- LONDON (AP) — Doctors in Britain, Italy, and Spain have been warned to look out for a rare inflammatory condition in children that is possibly linked to the new coronavirus. AP Health News: Coronavirus, April 28, 2020
- NAPLES, Italy (AP) — Wood is burning again in Naples’ pizza ovens, giving a symbolic and savory boost to Neapolitans after a two-month coronavirus lockdown meant an end to their most iconic and... AP Health News: Coronavirus, April 28, 2020
Spain
- BEIJING (AP) — Asian stock markets gained Wednesday after France and Spain joined governments that plan to ease anti-virus controls and allow businesses to reopen. AP Health News: Coronavirus, April 29, 2020
- BEIJING (AP) — Asian stock markets gained Wednesday after France and Spain joined governments that plan to ease anti-virus controls and allow businesses to reopen. AP Health News: Coronavirus, April 29, 2020
- LONDON (AP) — Doctors in Britain, Italy, and Spain have been warned to look out for a rare inflammatory condition in children that is possibly linked to the new coronavirus. AP Health News: Coronavirus, April 28, 2020
- Michael Robinson, from European Cup winner to the voice of Spanish TV | Sid Lowe The Guardian (U.K.) - Opinions: Coronavirus, April 28, 2020
France
- BEIJING (AP) — Asian stock markets gained Wednesday after France and Spain joined governments that plan to ease anti-virus controls and allow businesses to reopen. AP Health News: Coronavirus, April 29, 2020
- BEIJING (AP) — Asian stock markets gained Wednesday after France and Spain joined governments that plan to ease anti-virus controls and allow businesses to reopen. AP Health News: Coronavirus, April 29, 2020
- Argentina and France Scrap Soccer Seasons New York Times: Coronavirus, April 28, 2020
- France becomes latest country to end its soccer season because of coronavirus Washington Post: Coronavirus, April 28, 2020
United Kingdom
- His fight with virus is over, but British PM warns country now is time of 'maximum risk' NBC News: Coronavirus Latest News, April 28, 2020
- LONDON (AP) — Doctors in Britain, Italy, and Spain have been warned to look out for a rare inflammatory condition in children that is possibly linked to the new coronavirus. AP Health News: Coronavirus, April 28, 2020
- Britain Widens Its Coronavirus Testing Scheme New York Times: Coronavirus, April 28, 2020
Other International News
- Instantaneous R calculation for COVID-19 epidemic in Brazil MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- MUMBAI, India (AP) — Rafiq Maqbool remembers never flinching while covering high-risk news assignments such as the war in Afghanistan, the Sri Lankan tsunami or the conflict in Kashmir, where he... AP Health News: Coronavirus, April 29, 2020
- MEXICO CITY (AP) — Mexico’s Interior Department urged towns and states Tuesday to stop putting up roadblocks and curfews to stem the spread of the new coronavirus, as hundreds have done. AP Health News: Coronavirus, April 29, 2020
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Government
- COVID-19 Serology Surveillance Strategy CDC: Coronavirus Disease: What's New, April 29, 2020
- Testing for COVID-19 CDC: Coronavirus Disease: What's New, April 29, 2020
- Cases & Deaths by County CDC: Coronavirus Disease: What's New, April 29, 2020
- Care for Breastfeeding Women CDC: Coronavirus Disease: What's New, April 28, 2020
- Living in Shared Housing CDC: Coronavirus Disease: What's New, April 28, 2020
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Business and Economic News
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Business News
- Reopening states too early will bring deadlier outcomes, coronavirus projection models show CNN.com - Health, April 29, 2020
- Coronavirus antibody tests have 'really terrible' accuracy, researcher says CNN.com - Health, April 29, 2020
- Georgia's daily coronavirus deaths will nearly double by August with relaxed social distancing, model suggests CNN.com - Health, April 29, 2020
Economics Blogs
- Modeling COVID-19 on a network: super-spreaders, testing and containment Marginal Revolution, April 29, 2020
- Coronavirus Tourism in Sweden Armstrong Economic Blog, April 29, 2020
- Trump Says 'COVID Reparations' Coming: US Will Bill China At Least $160 Billion Zero Hedge, April 28, 2020
- MIT: What If COVID-19 Immunity Doesn't Last Long? Zero Hedge, April 28, 2020
- Coronavirus Compounds Challenges for Low-Income Communities and Communities of Color San Francisco Feds Blog, April 28, 2020
- Climate Resiliency in the Age of COVID-19 San Francisco Feds Blog, April 28, 2020
Top Economics News
- One of UK's richest businessmen says he expects oil at $40-$50 once the coronavirus crisis is over - CNBC (Brexit Economy News), April 29, 2020
- This is how coronavirus will upend the economy over the next year - Wired.co.uk (Brexit Economy News), April 29, 2020
- Barclays reports a 42% fall in profit and takes a $2.6 billion credit impairment charge on coronavirus - CNBC (Brexit Economy News), April 29, 2020
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Law Technology
- 445 million attacks detected since the beginning of 2020, COVID-19 wreaks havoc Help Net Security, April 29, 2020
- Designing the Patient Flow to Fight Covid-19 Lean Enterprise Institute, April 29, 2020
- Learning From Tech Innovation Trends In The COVID-19 Era Above the Law - Legal Technology (Legal Technology), April 28, 2020
Legal Administrator
- 4 Ways COVID-19 Has Impacted Collective Action EntertainHR, April 29, 2020
- Covid-19, Not Regulations, Is Uber's Number-One Problem Law and More, April 29, 2020
- Ashurst puts partner promotions on hold in response to Covid-19 Global Legal Post: Big Stories, April 28, 2020
Librarian News
- Only 33 prisoners in England and Wales released under anti-coronavirus measures House of Butter, April 29, 2020
- Texas Judge-Turned-Prisoner Calls COVID-19 a 'Death Sentence' as He Seeks Compassionate Release law.com: Newswire, April 29, 2020
- Federal Judge Says He Can't Order Immigration Courts to Close Over COVID-19 law.com: Newswire, April 29, 2020
Leading Law Departments
- A Lesson From COVID-19: Why Wait for a Crisis To Begin Managing It? Inside Counsel, April 28, 2020
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 | | Robert Morris, M.D., Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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