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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
3,282,349 |
232,182 |
| US |
1,080,210 |
62,675 |
Data from worldmeters.info
Research News
A detailed study of the impact of public health interventions** provides a clear picture of the effect of the type and timing of social distancing policies and estimates that, in the US alone, 5 million cases were prevented by intervention strategies.
Elevations in deaths from pneumonia and influenza**, particularly for the period before testing for COVID-19 was readily available, suggests a substantial underestimation in the number of deaths from COVID-19. This has major implications for our evaluation of public health interventions and case fatality rates.
A marked rise in out of hospital cardiac arrests over the course of the epidemic in Italy may explain the concurrent decrease in ST segment elevation myocardial infarctions observed in other studies. In other words, those with symptoms of an MI may have avoided hospitals during the peak of the pandemic with the result that untreated cases progressed to cardiac arrest.
Add the skin* to the list of organ systems affected by SARS-CoV-2. A Spanish study found five different categories of dermatological diseases in COVID-19 patients.
Ten percent of patients in China* shed the SARS-CoV-2 virus for more than 30 days and, among a group of such patients, the median duration of shedding was 53.5 days with a maximum of 81 days. This prolonged shedding is a major challenge for preventing reemergence of COVID-19.
More than half of "asymptomatic" cases* showed signs of pneumonia on chest CT in a Chinese study. This suggests that asymptomatic cases may have undetected pathology from the disease.
RNA sequencing data from COVID-19 patients** suggests that the SARS-CoV-2 virus may infect cells through phagocytosis in addition to the established ACE-2 receptor route. The study also finds evidence that pro-inflammatory signaling related to aging may play a role in exacerbating disease in the elderly and that a change in platelet gene expression might be at the root of coagulopathies.
A reduction in blood donors in China by 67% since the pandemic began raises serious concerns about the impact of COVID-19 on care for other diseases due to inadequate blood supplies.
* * * * *
*Accepted **Not peer reviewed.
Covid19- Ahead of the Curve.
* * * * *
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Clinical Laboratory and Diagnostics
- An Evolving Approach to the Laboratory Assessment of COVID‐19 Wiley: Coronavirus Research & News, April 30, 2020
- Uncertainties on the prognostic value of D‐dimers in COVID‐19 patients Wiley: Coronavirus Research & News, April 30, 2020
- Laboratory information system requirements to manage the COVID-19 pandemic: a report from the Belgian national reference testing center Oxford Academic Journals: Coronavirus, April 29, 2020
- Selecting a SARS-CoV-2/COVID molecular testing method for your laboratory Oxford Academic Journals: Coronavirus, April 29, 2020
- Cotton tipped plastic swabs for SARS-CoV-2 RT-qPCR diagnosis to prevent supplies shortage. MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
Emergency Care and Triage
- Virtual Remote Attending Supervision in an Academic Emergency Department during the COVID‐19 Pandemic Wiley: Coronavirus Research & News, April 30, 2020
- Characteristics of Emergency Department Patients With COVID‐19 at a Single Site in Northern California: Clinical Observations and Public Health Implications Wiley: Coronavirus Research & News, April 30, 2020
- A Marker of Systemic Inflammation or Direct Cardiac Injury: Should Cardiac Troponin Levels be Monitored in COVID-19 Patients? Oxford Academic Journals: Coronavirus, April 29, 2020
Infection Control
- COVID‐19: Infection prevention and control guidance for all ultrasound practitioners Wiley: Coronavirus Research & News, April 30, 2020
- Health workers' safety during tracheostomy in COVID‐19 patients: Homemade protective screen Wiley: Coronavirus Research & News, April 30, 2020
- Adapting reusable elastomeric respirators to utilise anaesthesia circuit filters using a 3D‐printed adaptor; a potential alternative to address N95 shortages during the COVID‐19 pandemic Wiley: Coronavirus Research & News, April 30, 2020
Clinical Case Management
- Employing Drug Delivery Strategies to Create Safe and Effective Pharmaceuticals for COVID‐19 Wiley: Coronavirus Research & News, April 30, 2020
- Quantitative clinical pharmacology input to SARS‐CoV‐2 therapeutics should be based on robust data Wiley: Coronavirus Research & News, April 30, 2020
- Response to “Quantitative clinical pharmacology input to SARS‐CoV‐2 therapeutics should be based on robust data” Wiley: Coronavirus Research & News, April 30, 2020
ICU Care
- The potential for COVID‐19 to contribute to compassion fatigue in critical care nurses Wiley: Coronavirus Research & News, April 30, 2020
Clinical Course and Outcomes
- The experience of treating patients with acute myocardial infarction under the COVID‐19 epidemic Wiley: Coronavirus Research & News, April 30, 2020
- HIV/SARS‐CoV‐2 co‐infected patients in Istanbul, Turkey Wiley: Coronavirus Research & News, April 30, 2020
- Elevations of serum cancer biomarkers correlate with severity of COVID‐19 Wiley: Coronavirus Research & News, April 30, 2020
Impact on Other Specialties
- Skull base surgery during the Covid‐19 pandemic: The Italian skull base society recommendations Wiley: Coronavirus Research & News, April 30, 2020
- Self‐removing passive drain to facilitate postoperative care via telehealth during the COVID‐19 pandemic Wiley: Coronavirus Research & News, April 30, 2020
- Procedural Precautions and Personal Protective Equipment during Head and Neck Instrumentation in the COVID‐19 Era Wiley: Coronavirus Research & News, April 30, 2020
Reviews, Commentary, and Miscellaneous
- Advising Medical Students during COVID‐19: The Case for a Single Emergency Medicine Rotation for All Wiley: Coronavirus Research & News, April 30, 2020
- COVID‐19: An Emeritus Faculty’s Perspective Wiley: Coronavirus Research & News, April 30, 2020
- Development of clinical care guidelines for faculty and residents in the era of COVID‐19 Wiley: Coronavirus Research & News, April 30, 2020
Drug Development
- Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in COVID-19 Patients Infectious Diseases Society of America Journals: Coronavirus, April 29, 2020
Newly Registered Clinical Trials
- To Study the Clinical Characteristics and Treatment Outcome of COVID-19 Patients Admitted in Hospitals of Max Healthcare (SCOPe Study) April 29, 2020
- Clinical Validation of New Injection Molded Flocked Nasopharyngeal Swabs in Response to the COVID-19 Pandemic April 29, 2020
- Comparison of Two Doses of Enoxaparin for Thromboprophylaxis in Hospitalized COVID-19 Patients April 29, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19 Infectious Diseases Society of America Journals: Coronavirus, April 29, 2020
- A gene locus that controls expression of ACE2 in virus infection MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
Vaccine Development
- COVID-19: Is Everything Appropriate to Create an Effective Vaccine? Infectious Diseases Society of America Journals: Coronavirus, April 29, 2020
- Custommune: a web tool to design personalized and population-targeted vaccine epitopes MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
Epidemiology
- Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China Infectious Diseases Society of America Journals: Coronavirus, April 30, 2020
- Epidemiological and Clinical Characteristics of 333 Confirmed Cases with Coronavirus Disease 2019 in Shanghai, China Wiley: Coronavirus Research & News, April 30, 2020
- Metropolitan Wastewater Analysis for COVID-19 Epidemiological Surveillance MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
Modeling and Prediction
- An improved mathematical prediction of the time evolution of the Covid-19 Pandemic in Italy, with Monte Carlo simulations and error analyses MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- A fractional-order SEIHDR model for COVID-19 with inter-city networked coupling effects MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Novel indicator of change in COVID-19 spread status MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- State-by-State prediction of likely COVID-19 scenarios in the United States and assessment of the role of testing and control measures MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
Public Health Intervention
- Covid-19 and Health at Work Oxford Academic Journals: Coronavirus, April 29, 2020
- Proactive social distancing mitigates COVID-19 outbreaks within a month across 58 mainland China cities MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Moving Personal Protective Equipment Into the Community: Face Shields and Containment of COVID-19 JAMA Network: Coronavirus, April 29, 2020
- Coronavirus (COVID‐19) in the United Kingdom: A personality‐based perspective on concerns and intention to self‐isolate Wiley: Coronavirus Research & News, April 30, 2020
Other
- Student engagement in a public health initiative in response to COVID‐19 Wiley: Coronavirus Research & News, April 30, 2020
- Internet Searches for Unproven COVID-19 Therapies in the United States JAMA Network: Coronavirus, April 29, 2020
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Coronavirus Research Resources
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China
- Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China Infectious Diseases Society of America Journals: Coronavirus, April 30, 2020
- Proactive social distancing mitigates COVID-19 outbreaks within a month across 58 mainland China cities MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Compared With China, U.S. Stay-At-Home Has Been 'Giant Garden Party,' Journalist Says NPR: Health, April 29, 2020
- Clinical Characteristics and Short-Term Outcomes of Severe Patients with COVID-19 in Wuhan, China MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Can the U.S. sue China for covid-19 damages? Not really. Washington Post: Coronavirus, April 29, 2020
South Korea
- Very few of Maryland’s coronavirus tests from South Korea have been used so far. Here’s why. Washington Post: Coronavirus, April 29, 2020
- Baseball is returning in South Korea — just without fans, high-fives or spitting Washington Post: Coronavirus, April 29, 2020
Italy
- An improved mathematical prediction of the time evolution of the Covid-19 Pandemic in Italy, with Monte Carlo simulations and error analyses MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- FIRST DETECTION OF SARS-COV-2 IN UNTREATED WASTEWATERS IN ITALY MedRxiv Server for Health Sciences: Coronavirus, April 29, 2020
- Italy Considers Permits For Undocumented Migrants To Fill A Big Farmworker Gap NPR: Health, April 29, 2020
- ROME (AP) — Every October, on the feast day of the patron saint of physicians, Dr. Roberto Stella organized a simple ceremony at a tiny church in northern Italy to honor Italian doctors who had... AP Health News: Coronavirus, April 29, 2020
Germany
- Potential coronavirus vaccine being tested in Germany could 'supply millions' by end of year CNN.com - Health, April 29, 2020
France
- In France, A New App Is Helping Doctors Monitor COVID-19 Patients Remotely NPR: Health, April 29, 2020
United Kingdom
- LONDON (AP) — The U.K. has the third-highest coronavirus death toll in the world after the British government published new figures Wednesday that include deaths outside of hospitals. AP Health News: Coronavirus, April 29, 2020
Other International News
- JERUSALEM (AP) — Social distancing doesn’t come naturally in Israel. But the country, known for its informal, in-your-face mentality, seems to be setting a new standard for public protests in the... AP Health News: Coronavirus, April 30, 2020
- MEXICO CITY (AP) — Police in southern Mexico may face charges after they opened fire on townspeople protesting an anti-virus roadblock that activists say cut their community off from the outside... AP Health News: Coronavirus, April 30, 2020
- Malaysia Reports 57 New Coronavirus Cases With Two New Deaths New York Times: Coronavirus, April 30, 2020
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Business and Economic News
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Business News
- Tesla Posts Another Profit as Musk Slams Virus Restrictions Wired.com, April 30, 2020
- Ad Dollars Keep Flowing Into Google and Facebook—for Now Wired.com, April 30, 2020
- FDA reportedly will approve Covid-19 treatment remdesivir, which US-funded trial shows has 'positive effect' on recovery CNN.com - Health, April 30, 2020
Economics Blogs
- Central banks’ Covid-19 policy response VoxEU.org, April 30, 2020
- This is How Bad the National Debt Explosion as a Result of COVID-19 Panic Is Economic Policy Journal, April 30, 2020
- Here Are The Last 34 Countries On Earth Yet To Report A Single COVID-19 Case Zero Hedge, April 29, 2020
Top Economics News
- Coronavirus: UK must Secure Brexit trade deal by December, says Raab - Metro.co.uk (Brexit Economy News), April 30, 2020
- The Scramble to Secure EU-UK Trade Ties Amid COVID-19 - Stratfor Worldview (Brexit Economy News), April 30, 2020
- Covid-19 impact on Wales 'could be more profound than rest of UK' - expressandstar.com (Brexit Economy News), April 30, 2020
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Law Technology
- Coronavirus shows the urgency of ensuring that research gets into the public domain RealKM, April 30, 2020
- COVID-19 Could Catalyze The Legal Industry Renaissance - Above the Law (Legal Technology), April 29, 2020
- 7 Fraud Predictions in the Wake of the Coronavirus Dark Reading, April 29, 2020
Legal Administrator
- Andrea Circle Bear - First Female Federal Inmate to Die of COVID-19 (after giving birth) Law and More, April 30, 2020
- Avi-Yonah: COVID-19 And U.S. Tax Policy TaxProf Blog, April 29, 2020
- Ohio's First Post-COVID Jury Trial Was Set to Begin. Then the Defendant Nearly Collapsed Blog of Legal Times, April 29, 2020
Librarian News
- Covid 19, Zoom & The Law of Wine House of Butter, April 30, 2020
- South Australia Law Society launches $1.8m COVID-19 relief package House of Butter, April 30, 2020
- Singapore Management University’s Covid-19 Seminar Series House of Butter, April 30, 2020
Leading Law Departments
- What Policy Management Insights Can We Learn During COVID-19? Mitratech: Press Releases, April 29, 2020
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 | | Robert Morris, M.D., Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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