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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
3,386,228 |
238,771 |
| US |
1,121,543 |
65,300 |
Data from worldmeters.info
Research News
An AI based search of a large electronic medical record database**, found that diarrhea and cough as well as disorders of smell and taste were strong predictors of a positive test for SARS-CoV-2 among those tested.
A team from Scotland** and a Cornell-led team** both argue that current interventions have primarily stabilized rates, but have not eliminated the disease, suggesting a reproduction number close to one. In light of that, both teams argue that relaxing social distancing will lead to renewed growth in disease rates.
A team of virologists disputes the notion that there are two strains of SARS-CoV-2. The authors suggest that proving independent functional differences would be extremely difficult, it is unlikely to happen, and there a many more strains of the virus than just those two.
A study of cases in Wuhan tracks the impact of public health interventions on the Reproduction Number, which hovered between 3 and 4 during the early stages of the outbreak but dropped dramatically with a city lockdown, traffic suspension and home quarantine, falling below 1.0 within two weeks.
Research from Taiwan traced and tested all household contacts of people returning from Wuhan. They document a secondary spread of only 0.7% among the 2761 contacts of 100 cases, which demonstrates the extremely effective response to the outbreak in that country.
Supplemental testing of samples collected for an ongoing study of the flu in Seattle documents a sharp rise in cases in the community starting on February 24, a month after the appearance of the first case. This suggests that an early aggressive lockdown might have dramatically attenuated the severity of the epidemic in Seattle and that cases were already widespread in the community at the time of the first death on February 26.
A multi-institutional study and a study from NYU both conclude that anti-hypertensive medication is not related to the course of COVID-19.
A study of the effect of stay at home orders** on people with pre-existing mental health conditions finds that their symptoms were improved by exercise, regular work, gardening, and worsened by media time and, among those receiving psychotherapy, interruption in treatment.
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*Preprint **Not peer reviewed.
Covid19- Ahead of the Curve.
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Clinical Laboratory and Diagnostics
- Throat Wash Testing and COVID-19 Disease: Should We Put Our Money Where Our Mouth Is? Oxford Academic Journals: Coronavirus, April 30, 2020
- Modeling SARS-CoV-2 positivity using laboratory data: timing is everything Oxford Academic Journals: Coronavirus, April 30, 2020
- Fast SARS-CoV-2 detection protocol based on RNA precipitation and RT-qPCR in nasopharyngeal swab samples MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- COVID‐19: Nasal and oropharyngeal swab Wiley: Coronavirus Research & News, May 1, 2020
- Increased travel times to United States SARS-CoV-2 testing sites: a spatial modeling study MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- COVID-19 diagnosis and study of serum SARS-CoV-2 specific IgA, IgM and IgG by chemiluminescence immunoanalysis MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
Emergency Care and Triage
- AutoTriage - An Open Source Edge Computing Raspberry Pi-based Clinical Screening System MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- Emergency Medical Services resource capacity and competency amid COVID-19 in the United States: Preliminary findings from a national survey MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Emergency Room Neurology in times of COVID‐19: Malignant Ischemic Stroke and SARS‐COV2 Infection Wiley: Coronavirus Research & News, May 1, 2020
- Preparedness and response to Pediatric CoVID-19 in European Emergency Departments: a survey of the REPEM and PERUKI networks MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
Infection Control
- Validation of N95 filtering facepiece respirator decontamination methods available at a large university hospital MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Protecting healthcare workers from inhaled SARS-CoV-2 virus Oxford Academic Journals: Coronavirus, April 30, 2020
Clinical Case Management
- Heparin therapy improving hypoxia in COVID-19 patients - a case series MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Testing an Old Therapy Against a New Disease: Convalescent Plasma for COVID-19 JAMA Network: Coronavirus, April 30, 2020
- Rapid Development of Resident-Led Procedural Response Teams to Support Patient Care During the Coronavirus Disease 2019 Epidemic: A Surgical Workforce Activation Team JAMA Network: Coronavirus, April 30, 2020
ICU Care
- Empirical evidence for safety of mechanical ventilation during simulated cardiopulmonary resuscitation on a physical model MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
Clinical Course and Outcomes
- SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection JAMA Network: Coronavirus, April 30, 2020
- COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options Oxford Academic Journals: Coronavirus, April 30, 2020
- Hydroxychloroquine, Coronavirus Disease 2019, and QT Prolongation JAMA Network: Coronavirus, May 1, 2020
- Association of Obesity with Disease Severity among Patients with COVID‐19 Wiley: Coronavirus Research & News, May 1, 2020
- Is the type of diabetes treatment relevant to outcome of COVID‐19? Wiley: Coronavirus Research & News, May 1, 2020
Impact on Other Specialties
- Letter: Neurosurgical Patients’ Management During the COVID-19 Pandemic—An Institutional Report From an African Neurosurgical Center Oxford Academic Journals: Coronavirus, May 1, 2020
- Letter: Safety Instructions for Neurosurgeons During COVID-19 Pandemic Based on Recent Knowledge and Experience Oxford Academic Journals: Coronavirus, May 1, 2020
- Letter: Back Pain and Accesses to Emergency Departments During COVID-19 Lockdown in Italy Oxford Academic Journals: Coronavirus, May 1, 2020
Reviews, Commentary, and Miscellaneous
- Our Health is the Public’s Health: Pain Management Leadership in the COVID-19 Pandemic Oxford Academic Journals: Coronavirus, April 30, 2020
- A deeper look at COVID-19 CFR: health care impact and roots of discrepancy MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- The Business of Medicine in the Era of COVID-19 JAMA Network: Coronavirus, May 1, 2020
Drug Development
- Antibody therapies for the treatment of COVID-19 Oxford Academic Journals: Coronavirus, April 30, 2020
- Modelling of Systemic versus Pulmonary Chloroquine Exposure in Man for COVID-19 Dose Selection MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Vitamin D, Quercetin, and Estradiol manifest properties of candidate medicinal agents for mitigation of the severity of pandemic COVID-19 defined by genomics-guided tracing of SARS-CoV-2 targets in human cells. ChemRxiv (Covid), April 30, 2020
- Renin–Angiotensin–Aldosterone System Blockers and Covid-19 New England Journal of Medicine: Coronavirus, May 1, 2020
- Phytotherapic compounds against coronaviruses: possible streams for future research Wiley: Coronavirus Research & News, May 1, 2020
Newly Registered Clinical Trials
- Radiographic Findings and Their Temporal Changes in COVID-19 Positive Changes Patients: A Prospective Study April 30, 2020
- A SINGLE-BLINDED RANDOMIZED, PLACEBO-CONTROLLED PHASE II TRIAL OF PROPHYLACTIC TREATMENT WITH ORAL AZITHROMYCIN VERSUS PLACEBO IN CANCER PATIENTS UNDERGOING ANTINEOPLASTIC TREATMENT DURING THE CORONA VIRUS DISEASE 19 (COVID-19) PANDEMIC April 30, 2020
- Clinical Application of Methylene Blue for Treatment of Covid-19 Patients April 30, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-COV-2 COVID-19 MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Isolation of a human monoclonal antibody specific for the receptor binding domain of SARS-CoV-2 using a competitive phage biopanning strategy Oxford Academic Journals: Coronavirus, April 30, 2020
- Covid‐19‐related pancreatic injury Wiley: Coronavirus Research & News, May 1, 2020
- Author response to: Covid‐19‐related pancreatic injury Wiley: Coronavirus Research & News, May 1, 2020
- SUCCESSFUL MANUFACTURING OF CLINICAL-GRADE SARS-CoV-2 SPECIFIC T CELLS FOR ADOPTIVE CELL THERAPY MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
Epidemiology
- Has mortality due to other causes increased during the Covid-19 pandemic? Early evidence from England and Wales MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- Spatial-temporal variations of atmospheric factors contribute to SARS-CoV-2 outbreak MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- Editorial: low population mortality from COVID‐19 in countries south of latitude 35 degrees North – supports vitamin D as a factor determining severity. Authors' reply Wiley: Coronavirus Research & News, May 1, 2020
Modeling and Prediction
- Bayesian Inference of COVID-19 Spreading Rates in South Africa MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- Multi-chain Fudan-CCDC model for COVID-19 in Iran MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- Monitoring trends and differences in COVID-19 case fatality rates using decomposition methods: Contributions of age structure and age-specific fatality MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
Public Health Intervention
- Povidone‐iodine gargle as a prophylactic intervention to interrupt the transmission of SARS‐CoV‐2 Wiley: Coronavirus Research & News, May 1, 2020
Mental Health
- COVID-19 and depressive symptoms in students before and during lockdown MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Mental Health in the Coronavirus Disease 2019 Emergency—The Italian Response JAMA Network: Coronavirus, April 30, 2020
- SARS-CoV-2 Infection in Travelers Returning from Wuhan New England Journal of Medicine: Coronavirus, May 1, 2020
- Effects of COVID‐19 Lockdown on Lifestyle Behaviors in Children with Obesity Living in Verona, Italy: A Longitudinal Study Wiley: Coronavirus Research & News, May 1, 2020
Surveillance and sero-epidemiology
- Poolkeh Finds the Optimal Pooling Strategy for a Population-wide COVID-19 Testing (Israel, UK, and US as Test Cases) MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Pooled testing with replication: a mass testing strategy for the COVID-19 pandemics MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
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Coronavirus Research Resources
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China
- China-Australia rift deepens over calls for virus inquiry AP Health News: Coronavirus, May 1, 2020
- WASHINGTON (AP) — President Donald Trump on Thursday speculated that China could have unleashed the coronavirus on the world due to some kind of horrible “mistake,” and his intelligence agencies... AP Health News: Coronavirus, May 1, 2020
- Tourists Trickle Back to Village by China's Great Wall as Virus Curbs Relaxed New York Times: Coronavirus, May 1, 2020
Iran
- Multi-chain Fudan-CCDC model for COVID-19 in Iran MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
South Korea
- South Korea Posts Biggest Exports Fall Since 2009, First Trade Deficit Since 2012 New York Times: Coronavirus, April 30, 2020
- Eye-opening South Korea study on Covid-19 CNN.com - Health, April 30, 2020
- South Korea Reports No New Domestic Coronavirus Cases NPR: Health, April 30, 2020
Italy
- Letter: Back Pain and Accesses to Emergency Departments During COVID-19 Lockdown in Italy Oxford Academic Journals: Coronavirus, May 1, 2020
- SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy MedRxiv Server for Health Sciences: Coronavirus, April 30, 2020
- Mental Health in the Coronavirus Disease 2019 Emergency—The Italian Response JAMA Network: Coronavirus, April 30, 2020
- The battle against COVID-19: mortality in Italy Oxford Academic Journals: Coronavirus, April 30, 2020
- Children with Covid-19 in Italy New England Journal of Medicine: Coronavirus, May 1, 2020
Germany
- Cut Us Some Slack, German Travel Start-Ups Tell Google New York Times: Coronavirus, May 1, 2020
- BERLIN (AP) — Politicians and scientists in Germany pushed back against calls for a rapid relaxation of pandemic restrictions as new figures released Thursday showed that businesses have applied... AP Health News: Coronavirus, April 30, 2020
- The Latest on the effects of the coronavirus outbreak on sports around the world: ___ German chancellor Angela Merkel says a decision on whether the country’s soccer league can resume... AP Health News: Coronavirus, April 30, 2020
France
- PARIS (AP) — Paris Saint-Germain was declared champion of the French soccer league on Thursday after the season ended early because of the coronavirus pandemic. AP Health News: Coronavirus, April 30, 2020
- After Surviving COVID-19, French Neurosurgeon Faces Long Road to Recovery New York Times: Coronavirus, April 30, 2020
United Kingdom
- Has mortality due to other causes increased during the Covid-19 pandemic? Early evidence from England and Wales MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- An English Brewery Offers Free Beer In Exchange For Donating To Health Workers NPR: Health, May 1, 2020
Other International News
- CANBERRA, Australia (AP) — China’s warning of trade repercussions from Australia’s campaign for an independent inquiry into the coronavirus has rattled Australian business leaders as President... AP Health News: Coronavirus, May 1, 2020
- SAN DIEGO (AP) — The Trump administration on Thursday suspended immigration court hearings for asylum-seekers waiting in Mexico through June 1, bowing to public health concerns while extending a... AP Health News: Coronavirus, May 1, 2020
- Indonesia Reports 433 New Coronavirus Cases, Eight Deaths New York Times: Coronavirus, May 1, 2020
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Business and Economic News
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Business News
- Most US states are reopening within days but some need time 'to remain vigilant' CNN.com - Health, May 1, 2020
- Funeral Director First Responder: 'You're Stronger Than You Feel' NPR: Health, May 1, 2020
- Opinion: Always The Bridesmaid, Public Health Rarely Spotlighted Until It's Too Late NPR: Health, May 1, 2020
Economics Blogs
- Supporting parents and children in the early years during (and after) the COVID-19 crisis VoxEU.org, May 1, 2020
- The economic risk from COVID-19 is not where COVID-19 is VoxEU.org, May 1, 2020
- Amazon Says It May Lose Money During Coronavirus as It Increases Spending on Logistics and Worker Safety The Curious Capitalist, May 1, 2020
Top Economics News
- Global recession warning: Coronavirus crisis tears apart world economies - dire prediction - Express (Brazilian Economy), May 1, 2020
- Brexit Trade Talks Back on Agenda After COVID-19 Hiatus, Facing Tight Timetable - Insurance Journal (Brexit Economy News), May 1, 2020
- Hard Numbers: Somali healthcare crisis, UK COVID test failure, Colombian prison riot, views on women's rights - GZERO Media (Colombian Economy), May 1, 2020
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Law Technology
- Tech Companies, ABA, Partner to Launch National Pro Bono Portal Targeting COVID-19 and Disaster Relief Robert Ambrogi's LawSites, April 30, 2020
- Developing a Standard of Testing for Covid-19 using Data Modeling and AI ILTA Blogs, April 30, 2020
- Will Covid-19 Impact On e-Discovery Market ? – Identify Which Types Of Companies Could Potentially Benefit - Latest Herald (eDiscovery), April 30, 2020
Legal Administrator
- Minimizing the Risk Of COVID-19 Infection Lawsuits Filed by Employees EntertainHR, May 1, 2020
- Tech Companies, ABA, Partner to Launch National Pro Bono Portal Targeting COVID-19 and Disaster Relief Law Sites Blog, April 30, 2020
- Gilead's Suing the Feds, and Working With Them, Amid Coronavirus Outbreak Blog of Legal Times, April 30, 2020
Librarian News
- Singapore Academy of Law launches COVID-19 microsite House of Butter, May 1, 2020
- USA: Wolters Kluwer Launches MediRegs COVID-19 Regulatory Search for Federal and State Regulations House of Butter, May 1, 2020
- Fashion Law Institute at Fordham Webinar “Going Viral: Fashion and the Coronavirus,” House of Butter, May 1, 2020
Leading Law Departments
- Preparing for the New Normal: How Legal Can Survive (and Thrive) Beyond COVID-19? Inside Counsel, April 30, 2020
- In-House Counsel: Prosecutors Won't Overlook Remote Wrongdoing in COVID-19 Times Inside Counsel, April 30, 2020
- 15 Coronavirus Survival Tips for Your Legal Ops Ecosystem Mitratech: Press Releases, April 30, 2020
- Limitation of Liability During the Coronavirus Pandemic General Counsel News, May 1, 2020
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 | | Robert Morris, M.D., Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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