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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
3,633,833 |
251,480 |
| US |
1,208,036 |
69,384 |
Data from worldmeters.info
Asymptomatic Is Not the Same as Unaffected This disease didn't even exist six months ago, so it is absurd to think we understand all of the ways it can harm us. We must allow for the possibility that, in this case, what doesn't kill you makes you weaker.
Research News
A study of the secondary attack rates for COVID-19 using detailed contact tracing for nine cases found two secondary infections out of 159 close contacts. Both cases were spouses of the nine known cases. The secondary attack rate among household members was 13%. These results would imply either that the disease is not as contagious as suggested by some recent seroprevalence studies or that the respiratory samples used in this study were missing some portion of asymptomatic cases.
An evaluation of SARS-CoV-2 antibody tests from Abbot Labs demonstrated a specificity of 99.90% and, at 17 days after first positive RT-PCR test for the virus, a sensitivity of 100% based on 1,020 serum samples. A separate analysis in Boise Idaho found that, among people who actively registered for testing, 1.79% had antibodies. This is likely to represent an upper boundary for zero-prevalence, given that those volunteering to be tested are more likely to have concerns about exposure.
An estimation of the negative psychosocial consequences of home isolation orders based purely on modeling, concluded that suicides, divorces, family violence, depression, and alcohol abuse would result in a the loss of 1,757,498 years of life in Switzerland if the stay at home orders are maintained for three full months. There are no data to support this conclusion, but it is important to consider in evaluating the costs and benefits intervention strategies.
The dubious paper of the day award goes to a Chinese study arguing that the disease originated in Washington State based on sequencing of viral isolates and was brought from there to China.
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*Preprint **Not peer reviewed.
Covid19- Ahead of the Curve.
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Top News
- Performance Characteristics of the Abbott Architect SARS-CoV-2 IgG Assay and Seroprevalence Testing in Idaho MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
- Enhanced Contact Investigations for Nine Early Travel-Related Cases of SARS-CoV-2 in the United States MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- Estimation of SARS-CoV-2 emissions from non-symptomatic cases MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- Years of life lost due to the psychosocial consequences of COVID19 mitigation strategies based on Swiss data MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
- Genome-wide variations of SARS-CoV-2 infer evolution relationship and transmission route MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
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Clinical Laboratory and Diagnostics
- Automated Diagnosis of COVID-19 Using Deep Learning and Data Augmentation on Chest CT MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- False positives in reverse transcription PCR testing for SARS-CoV-2 MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- Predictive value of sudden olfactory loss in the diagnosis of COVID-19 MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
Infection Control
- How Social Media and 3D Printing Tackles the PPE Shortage during Covid - 19 Pandemic MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- Health and safety considerations for hotel cleaners during Covid-19 Oxford Academic Journals: Coronavirus, May 2, 2020
Clinical Case Management
- COVID-19, superinfections and antimicrobial development: What can we expect? Infectious Diseases Society of America Journals: Coronavirus, May 3, 2020
- Bacterial and fungal co-infection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing Oxford Academic Journals: Coronavirus, May 2, 2020
- Antenatal corticosteroid therapy and COVID‐19 : pathophysiological considerations Wiley: Coronavirus Research & News, May 1, 2020
- Cutaneous lesions in a patient with COVID‐19: are they related? Wiley: Coronavirus Research & News, May 1, 2020
- The effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on death and severity of disease in patients with coronavirus disease 2019 (COVID-19): A meta-analysis MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
- Hydroxychloroquine is associated with slower viral clearance in clinical COVID-19 patients with mild to moderate disease: A retrospective study MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
Clinical Course and Outcomes
- Clinical and laboratory predictors of in-hospital mortality in patients with COVID-19: a cohort study in Wuhan, China Oxford Academic Journals: Coronavirus, May 3, 2020
- Acute myocardial injury, MINOCA, or myocarditis? Improving characterization of coronavirus-associated myocardial involvement Oxford Academic Journals: Coronavirus, May 3, 2020
- Does SARS-CoV-2 cause viral myocarditis in COVID-19 patients? Oxford Academic Journals: Coronavirus, May 3, 2020
- Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Hospitalized Patients in Wuhan, China Oxford Academic Journals: Coronavirus, May 3, 2020
- Acute aorto‐iliac and mesenteric arterial thromboses as presenting features of COVID‐19 Wiley: Coronavirus Research & News, May 1, 2020
- Longitudinal Change of SARS-Cov2 Antibodies in Patients with COVID-19 Oxford Academic Journals: Coronavirus, May 2, 2020
Impact on Other Specialties
- Letter: The Resiliency of the Neurosurgeon in the Midst of COVID-19 Pandemic Storm: The Italian Experience From the Frontline Oxford Academic Journals: Coronavirus, May 3, 2020
- Letter: Neurological Implications of COVID-19 and Lessons Learned From Prior Epidemics and Pandemics Oxford Academic Journals: Coronavirus, May 3, 2020
- Autopsy in suspected COVID-19 cases. NIH: National Library of Medicine: Coronavirus, May 3, 2020
Reviews, Commentary, and Miscellaneous
- COVID-19 and healthcare lessons already learned Oxford Academic Journals: Coronavirus, May 4, 2020
- SARS, MERS and COVID-19—new threats; old lessons Oxford Academic Journals: Coronavirus, May 3, 2020
- An Interactive Tool to Forecast US Hospital Needs in the Coronavirus 2019 Pandemic MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
Drug Development
- Tripartite combination of potential pandemic mitigation agents: Vitamin D, Quercetin, and Estradiol manifest properties of candidate medicinal agents for mitigation of the severity of pandemic COVID-19 defined by genomics-guided tracing of SARS-CoV-2 targets in human cells. ChemRxiv (Covid), May 4, 2020
- Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease Oxford Academic Journals: Coronavirus, May 3, 2020
- Favipiravir for treating novel coronavirus (COVID-19) patients: protocol for a systematic review and meta-analysis of controlled trials MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- Dramatic improvement after Tocilizumab of a severe COVID‐19 in a child with sickle cell disease and acute chest syndrome Wiley: Coronavirus Research & News, May 1, 2020
- Challenges in Drug Development Posed by the COVID‐19 Pandemic: An Opportunity for Clinical Pharmacology Wiley: Coronavirus Research & News, May 1, 2020
- Response to "Dose rationale for favipiravir use in patients infected with SARS‐CoV‐2" Wiley: Coronavirus Research & News, May 1, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Deducing the N- and O- glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2 Oxford Academic Journals: Coronavirus, May 4, 2020
- Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. NIH: National Library of Medicine: Coronavirus, May 3, 2020
- SARS-CoV-2 receptor mutation in Egyptian population MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
- Histopathology and genetic susceptibility in COVID‐19 pneumonia Wiley: Coronavirus Research & News, May 1, 2020
- Proteome-wide analysis of differentially-expressed SARS-CoV-2 antibodies in early COVID-19 infection MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
Epidemiology
- Estimation of Undetected Covid-19 Infections in India MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- Who is at the highest risk from COVID-19 in India? Analysis of health, healthcare access, and socioeconomic indicators at the district level MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- Race, Socioeconomic Deprivation, and Hospitalization for COVID-19 in English participants of a National Biobank MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
Modeling and Prediction
- A Predictive Model of the Temperature-Dependent Inactivation of Coronaviruses ChemRxiv (Covid), May 4, 2020
- A fractional-order SEIHDR model for COVID-19 with inter-city networked coupling effects MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- Forecast analysis of the epidemics trend of COVID-19 in the United States by a generalized fractional-order SEIR model MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
Public Health Intervention
- COVID-19 spreading in Rio de Janeiro, Brazil: do the policies of social isolation really work? MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- COVID-19 mathematical model reopening scenarios for Sao Paulo - Brazil MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
- First peak of COVID−19 outbreak in Japan might pass as of April 26, 2020 MedRxiv Server for Health Sciences: Coronavirus, May 1, 2020
Mental Health
- Severe psychological distress among epilepsy patients during the COVID‐19 outbreak in southwest China Wiley: Coronavirus Research & News, May 1, 2020
- When the storm is the strongest: The health conditions and job satisfaction of Healthcare staff and their associated predictors during the epidemic peak of COVID-19 MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
Surveillance and sero-epidemiology
- Role of serology in the COVID-19 pandemic Oxford Academic Journals: Coronavirus, May 1, 2020
- Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
- Evaluation of COVID-19 RT-qPCR test in multi-sample pools Oxford Academic Journals: Coronavirus, May 2, 2020
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Coronavirus Research Resources
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China
- China Reports Three New Coronavirus Cases, All Imported New York Times: Coronavirus, May 3, 2020
- Dollar Firm but Stocks, Oil Under Pressure as U.S.-China Tensions Rise New York Times: Coronavirus, May 3, 2020
- Jeremy Lin sparks another run of Linsanity, this time tempered by the coronavirus in China Washington Post: Coronavirus, May 3, 2020
Iran
- WHO delivers more medicines to Islamic Republic of Iran for COVID-19 “Solidarity” clinical trial WHO: Coronavirus disease (COVID-19) news, May 4, 2020
- Afghanistan Probes Report Iranian Border Guards Forced Migrants Into River, Many Drowned New York Times: Coronavirus, May 3, 2020
South Korea
- South Korea's April Factory Activity Suffers Severely as Export Orders Shrink at Record Pace: PMI New York Times: Coronavirus, May 3, 2020
- SEOUL, South Korea (AP) — North Korean leader Kim Jong Un did not undergo surgery or any other medical procedure, a South Korean official said Sunday, amid speculation about his health that... AP Health News: Coronavirus, May 3, 2020
- SEOUL, South Korea (AP) — North Korean leader Kim Jong Un made his first public appearance in 20 days as he celebrated the completion of a fertilizer factory near Pyongyang, state media said... AP Health News: Coronavirus, May 1, 2020
Italy
- Letter: The Resiliency of the Neurosurgeon in the Midst of COVID-19 Pandemic Storm: The Italian Experience From the Frontline Oxford Academic Journals: Coronavirus, May 3, 2020
- CASTIONE DELLA PRESOLANA, Italy (AP) — As Italy gradually emerges from its two-month coronavirus lockdown, tourism operators in the hard-hit Val Seriana valley look ahead with trepidation at an... AP Health News: Coronavirus, May 3, 2020
- An ARIMA Model to Forecast the Spread and the Final Size of COVID-2019 Epidemic in Italy MedRxiv Server for Health Sciences: Coronavirus, May 3, 2020
- I Bought a Car From Northern Italy as the Pandemic Took Hold New York Times: Coronavirus, May 3, 2020
Spain
- Bolivian Light Plane Crash Kills Six, Including Four Spanish Citizens New York Times: Coronavirus, May 2, 2020
- Adults In Spain Get A Bit Of Sunshine As Coronavirus Lockdown Partially Lifts NPR: Health, May 2, 2020
- BARCELONA, Spain (AP) — Spaniards filled the streets Saturday to exercise outside in gorgeous spring weather for the first time in seven weeks, while German children rushed to playgrounds as... AP Health News: Coronavirus, May 2, 2020
- BARCELONA, Spain (AP) — Thousands of Spaniards woke early and laced up their sports shoes Saturday after a prohibition on outdoor exercise during the coronavirus pandemic ended after seven weeks.... AP Health News: Coronavirus, May 2, 2020
- Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
Germany
- Climate in German Auto Sector Slumps Ahead of Crunch Merkel Meeting New York Times: Coronavirus, May 4, 2020
- Spaniards have filled the streets to exercise outside in gorgeous spring weather for the first time in seven weeks and German children rushed to playgrounds as countries in Western Europe... AP Health News: Coronavirus, May 2, 2020
- BARCELONA, Spain (AP) — Spaniards filled the streets Saturday to exercise outside in gorgeous spring weather for the first time in seven weeks, while German children rushed to playgrounds as... AP Health News: Coronavirus, May 2, 2020
United Kingdom
- LONDON (AP) — Prime Minister Boris Johnson has offered more insight into his hospitalization for coronavirus, telling a British newspaper that he knew doctors were preparing for the worst.... AP Health News: Coronavirus, May 3, 2020
- Grief, questions and bitter frustration beneath Britain's mounting death toll NBC News: Coronavirus Latest News, May 2, 2020
- MANCHESTER, Engalnd (AP) — The English Premier League stepped up planning on Friday to try to resume in neutral stadiums, holding separate talks with the government and its clubs to determine the... AP Health News: Coronavirus, May 2, 2020
- Race, Socioeconomic Deprivation, and Hospitalization for COVID-19 in English participants of a National Biobank MedRxiv Server for Health Sciences: Coronavirus, May 2, 2020
Other International News
- WELLINGTON, New Zealand (AP) — There were signs Monday that the coronavirus pandemic was easing significantly in some parts of Europe but getting worse in India and Russia. AP Health News: Coronavirus, May 4, 2020
- Indonesia Reports 395 New Coronavirus Infections, 19 Deaths New York Times: Coronavirus, May 4, 2020
- COVID-19 and the Future of Microfinance: Evidence and Insights from Pakistan Oxford Academic Journals: Coronavirus, May 3, 2020
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Business and Economic News
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Business News
- 'So many more deaths than we could have ever imagined.' This is how America's largest city deals with its dead CNN.com - Health, May 4, 2020
- Trump again shifts estimated US coronavirus death toll CNN.com - Health, May 4, 2020
- Despite Coronavirus Risks, The U.S. Senate Returns For Normal Business NPR: Health, May 4, 2020
Economics Blogs
- Debt restructuring in the time of COVID-19 VoxEU.org, May 4, 2020
- The Impact of COVID-19 on America’s Economy The Daily Signal: Heritage.org, May 4, 2020
- David Stockman On The Three Nations Of COVID, & A Windbag Named Fauci Zero Hedge, May 3, 2020
Top Economics News
- Job postings decline by half due to impact of Covid-19, recruiter says - The Irish Times (Brexit Economy News), May 4, 2020
- India Manufacturing Sector Contracts On COVID-19 Pandemic RTT News: Asian Economic News, May 4, 2020
- Pompeo Continues the China Blame Game: Says "Enormous Evidence" Points to Coronavirus Originating in Chinese Lab - Foreign Policy (Colombian Economy), May 4, 2020
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Law Technology
- Digital Transformations in the Post-Covid World Data Science Central: Featured Blog Posts, May 3, 2020
- COVID-19 Lesson: Digital Transformation Is an Essential Service Data Science Central: Featured Blog Posts, May 3, 2020
- 'A passionate champion for social justice' - victims of Covid-19 remembered Global Legal Post: Big Stories, May 3, 2020
Legal Administrator
- "World on Fire" - Who Are We Becoming in The Time of COVID-19? Law and More, May 4, 2020
- COVID-19 Lawsuits - Almost 800, Decisions in Some Will Break New Ground Law and More, May 3, 2020
- 'A passionate champion for social justice' - victims of Covid-19 remembered Global Legal Post: Big Stories, May 3, 2020
- "Julia Dutra, et al. v. Trustees of Boston University" - Unintended Consequences on Higher Education from COVID-19 Law and More, May 2, 2020
- The Highest-Ranked Am Law 100 Firm To Slash Salaries Due To COVID-19 Above the Law - Big Law, May 1, 2020
Librarian News
- LegalZoom Sponsors National Disaster Relief Portal Created by American Bar Association and Paladin to Provide Free Legal Services to Those Impacted by COVID-19 House of Butter, May 4, 2020
- Press Release: LAWCLERK Launches Legal Outsourcing Toolkit to Help Remote Lawyers Manage Caseloads During the COVID-19 Pandemic House of Butter, May 4, 2020
- Writing the Book on Coronavirus and the Law – The Wolf at the Door: The Menace of Economic Insecurity and How to Fight It, House of Butter, May 4, 2020
Leading Law Departments
- Can’t Make Bail, Sit in Jail Even Longer Thanks to Coronavirus General Counsel News, May 3, 2020
- Top impacts of COVID-19 on the enterprise Agiloft Blog, May 1, 2020
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 | | Robert Morris, M.D., Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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