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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
4,798,132 |
316,507 |
| US |
1,526,813 |
90,973 |
Data from worldmeters.info
Herd Immunity and COVID-19: The Debate That May Define Our Next Step The seemingly simple concept defines the ultimate exit strategy for the disease. But the reality of this tiny virus seems endlessly complex. A few recent papers have proposed a nuanced view of herd immunity that some will be sure to insist should be part of our plans for ending the lockdown.
Research News
A vaccine trial in rhesus macaque monkeys** of an adenovirus vectored vaccine encoding the spike protein of SARS-CoV-2 reduced viral load and prevented pneumonia following viral challenge. This vaccine has already been entered into Phase I clinical trials and shows promise as a potential human vaccine.
A trial of monoclonal antibodies against the SARS-CoV-2 spike protein** in transgenic mice identified a specific antibody that protected against a intranasal challenge with the virus. Given the evidence that injection of antibodies from human plasma improves recovery time, this finding suggests the possibility of a treatment based on monoclonal antibodies.
A study of the genetics of corona viruses in bats** finds evidence of intercontinental dispersal of beta-coronaviruses in bats from China and Hong Kong to Central and Southern Africa. Given the demonstrated potential for these viruses to cause devastating disease, this news should spark expanded efforts to study and monitor this potential source of zoonotic infections.
A paper describing a model of herd immunity asserts** that individual heterogeneity could reduce the required level of herd immunity to control the spread of COVID-19. The model does not take into account environmental and social factors that influence the spread of the virus.
Expression of ACE2 in the olfactory neuroepithelium** may explain both CNS involvement in the COVID-19 epidemic and the loss of smell often associated with the disease.
Expression of ACE2 on the surface of the eye** confirms this as a potential route of exposure and infection for SARS-CoV-2. This should be carefully considered in future infection control efforts.
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*Preprint **Not peer reviewed.
Covid19- Ahead of the Curve.
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Top News
- ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- Potent neutralization of SARS-CoV-2 in vitro and in an animal model by a human monoclonal antibody bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- The disease-induced herd immunity level for Covid-19 is substantially lower than the classical herd immunity level MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- Evolutionary Dynamics And Geographic Dispersal Of Beta Coronaviruses In African Bats bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
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Clinical Laboratory and Diagnostics
- A rapid, point of care red blood cell agglutination assay for detecting antibodies against SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- CRISPR-Assisted DNA Detection, a novel dCas9-based DNA detection technique bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- Comparison of the Accula SARS-CoV-2 Test with a Laboratory-Developed Assay for Detection of SARS-CoV-2 RNA in Clinical Nasopharyngeal Specimens bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
Emergency Care and Triage
- Development and validation of the COVID-19 severity index (CSI): a prognostic tool for early respiratory decompensation MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- COVID-19 diagnosis prediction by symptoms of tested individuals: a machine learning approach MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- ACE2 interaction networks in COVID-19: a physiological framework for prediction of outcome in patients with cardiovascular risk factors bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- Emergency ambulance services for heart attack and stroke during UK's COVID-19 lockdown Lancet: COVID-19 Resource Centre (Covid), May 14, 2020
Infection Control
- Necessity of Pharmacist-driven non-prescription telehealth consult services in the era of COVID-19 Oxford Academic Journals: Coronavirus, May 14, 2020
- Analysis of the infection status of the health care workers in Wuhan during the COVID-19 outbreak: A cross-sectional study Oxford Academic Journals: Coronavirus, May 15, 2020
- Physician deaths from corona virus (COVID-19) disease Oxford Academic Journals: Coronavirus, May 15, 2020
- Potential spreading risks and disinfection challenges of medical wastewater by the presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viral RNA in septic tanks of fangcang hospital MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
Clinical Case Management
- COVID-19 in patients with HIV Lancet: COVID-19 Resource Centre (Covid), May 14, 2020
- COVID-19 in patients with HIV – Authors' reply Lancet: COVID-19 Resource Centre (Covid), May 14, 2020
- Management of acute kidney injury in patients with COVID-19 Lancet: COVID-19 Resource Centre (Covid), May 14, 2020
- Angiotension-converting enzyme inhibitors and angiotensin-receptor blockers are not associated with increased risk of SARS-CoV-2 infection Oxford Academic Journals: Coronavirus, May 14, 2020
- Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. NIH: National Library of Medicine: Coronavirus, May 14, 2020
- Risk Factors of Severe Disease and Efficacy of Treatment in Patients Infected with COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression Analysis Infectious Diseases Society of America Journals: Coronavirus, May 14, 2020
ICU Care
- Simple ventilators for emergency use based on Bag-Valve pressing systems: Lessons learned and future steps MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
Clinical Course and Outcomes
- Lung Disease Network Reveals the Impact of Comorbidity on SARS-CoV-2 infection bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- The role of high cholesterol in age-related COVID19 lethality bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- Characteristics and Outcomes of Coronavirus Disease Patients under Nonsurge Conditions, Northern California, USA, March–April 2020 CDC: Emerging Infectious Diseases, May 14, 2020
Impact on Other Specialties
- Changes in the work mode of cardiologists during the COVID-19 epidemic in Wuhan Oxford Academic Journals: Coronavirus, May 14, 2020
- Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. NIH: National Library of Medicine: Coronavirus, May 14, 2020
- Reduction in emergency surgery activity during COVID‐19 pandemic in three Spanish hospitals Wiley: Coronavirus Research & News, May 15, 2020
Reviews, Commentary, and Miscellaneous
- Global view on virus infection in non-human primates and implication for public health and wildlife conservation bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- COVID-19 research in Wikipedia bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- An appeal for practical social justice in the COVID-19 global response in low-income and middle-income countries Lancet: COVID-19 Resource Centre (Covid), May 14, 2020
Mental Health
- Letter to the Editor—Behavioral Health Implications of Inmate Release During COVID‐19 Wiley: Coronavirus Research & News, May 15, 2020
- Mental health nursing at a time of crisis Wiley: Coronavirus Research & News, May 15, 2020
- Mental health participation in the fight against the COVID‐19 pandemic Wiley: Coronavirus Research & News, May 15, 2020
- Three steps to flatten the mental health need curve amid the COVID‐19 pandemic Wiley: Coronavirus Research & News, May 15, 2020
Drug Development
- Screening of Anticancer Drugs as Potential Candidates to Target COVID-19 Disease ChemRxiv (Covid), May 14, 2020
- Identification of Atovaquone, Ouabain and Mebendazole as FDA Approved Drugs Tar-geting SARS-CoV-2 (Version 4) ChemRxiv (Covid), May 14, 2020
- Pharmaceutical Targeting the Envelope Protein of SARS-CoV-2: the Screening for Inhibitors in Approved Drugs ChemRxiv (Covid), May 14, 2020
Newly Registered Clinical Trials
- Post Covid-19 Cardiopulmonary and Immunological Changes May 14, 2020
- The NO-COVID Study May 14, 2020
- Sarilumab for Patients With Moderate COVID-19 Disease May 14, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- SARS-CoV-2 spike protein predicted to form stable complexes with host receptor protein orthologues from mammals bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- A transcriptional regulatory atlas of coronavirus infection of human cells bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- Whole genome sequencing and phylogenetic analysis of SARS-CoV-2 strains from the index and early patients with COVID-19 in Dubai, United Arab Emirates, 29 January to 18 March 2020 bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
Vaccine Development
- Development of a COVID-19 vaccine based on the receptor binding domain displayed on virus-like particles bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- In Silico Trial to test COVID-19 candidate vaccines: a case study with UISS platform bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
Epidemiology
- Multiple introductions, regional spread and local differentiation during the first week of COVID-19 epidemic in Montevideo, Uruguay bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- Multiple SARS-CoV-2 introductions shaped the early outbreak in Central Eastern Europe: comparing Hungarian data to a worldwide sequence data-matrix bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. NIH: National Library of Medicine: Coronavirus, May 14, 2020
Modeling and Prediction
- Monitoring and Tracking the Evolution of a Viral Epidemic Through Nonlinear Kalman Filtering: Application to the Covid-19 Case MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- Forecasting Transmission Dynamics of COVID-19 Epidemic in India under Various Containment Measures- A Time-Dependent State-Space SIR Approach MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- Spread of COVID-19 in India: A Simple Algebraic Study MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
Public Health Intervention
- COVID-19: Easing the coronavirus lockdowns with caution MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- Leveraging Africa's preparedness towards the next phase of the COVID-19 pandemic Lancet: COVID-19 Resource Centre (Covid), May 14, 2020
- Estimating COVID-19 outbreak risk through air travel MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
Surveillance and sero-epidemiology
- Antibody Testing For Covid-19: Oxford Academic Journals: Coronavirus, May 15, 2020
- Screening of SARS-CoV-2 among homeless people, asylum seekers and other people living in precarious conditions in Marseille, France, March April 2020. MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- Tracking R of COVID-19: A New Real-Time Estimation Using the Kalman Filter MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
Other
- Applying Lexical Link Analysis to Discover Insights from Public Information on COVID-19 bioRxiv: The Preprint Server for Biology (Covid), May 14, 2020
- High-dose influenza vaccination and mortality among predominantly male, white, senior veterans, United States, 2012/13 to 2014/15 Eurosurveillance, May 14, 2020
- Authors’ correction for Euro Surveill. 2020;25(17) Eurosurveillance, May 14, 2020
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Coronavirus Research Resources
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China
- Case fatality risk of the first pandemic wave of novel coronavirus disease 2019 (COVID-19) in China Infectious Diseases Society of America Journals: Coronavirus, May 15, 2020
- Biden vs. Trump: The ad battle over China and the coronavirus Washington Post: Coronavirus, May 15, 2020
- Is a U.S.-China Cold War already underway? Washington Post: Coronavirus, May 15, 2020
South Korea
- South Korea Pledges More Steps to Tackle Pandemic Employment Shock New York Times: Coronavirus, May 14, 2020
- Machine learning model estimating number of COVID-19 infection cases over coming 24 days in every province of South Korea (XGBoost and MultiOutputRegressor) MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
Italy
- How deadly is COVID-19? A rigorous analysis of excess mortality and age-dependent fatality rates in Italy MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- Patterns of COVID-19 related excess mortality in the municipalities of Northern Italy MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- An empirical estimate of the infection fatality rate of COVID-19 from the first Italian outbreak MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- Polish medics bring Italian COVID-19 experience to Kyrgyzstan with WHO support WHO: Coronavirus disease (COVID-19) news, May 14, 2020
- ROME (AP) — Italian convicted mobsters who had been temporarily transferred from prison to house arrest for fear of coronavirus contagion are being brought back behind bars, the country's justice... AP Health News: Coronavirus, May 14, 2020
France
- Dentists carefully reopen in France after 2-month lockdown AP Health News: Coronavirus, May 14, 2020
- Screening of SARS-CoV-2 among homeless people, asylum seekers and other people living in precarious conditions in Marseille, France, March April 2020. MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- Outbreak of Kawasaki disease in children during COVID-19 pandemic: a prospective observational study in Paris, France MedRxiv Server for Health Sciences: Coronavirus, May 14, 2020
- PARIS (AP) — French pharmaceutical group Sanofi promised Thursday that it would make its COVID-19 vaccine, when ready, available in all countries, hours after the company's CEO said the United... AP Health News: Coronavirus, May 14, 2020
- France angered by suggestion U.S. would get first access to coronavirus vaccine by French pharma company Sanofi Washington Post: Coronavirus, May 14, 2020
United Kingdom
- The Latest on the effects of the coronavirus outbreak on sports around the world: ___ The British government says it is helping the Premier League resume in June but it wants the... AP Health News: Coronavirus, May 14, 2020
- BRUSSELS (AP) — The European Commission said Thursday it has suspended the delivery of 10 million Chinese masks to member states and Britain after two countries complained about the poor quality... AP Health News: Coronavirus, May 14, 2020
Other International News
- ATHENS, Greece (AP) — President Donald Trump is never far from a public spat with his government’s top expert on the pandemic, Dr. Anthony Fauci, the most recent flare-up occurring this week over... AP Health News: Coronavirus, May 15, 2020
- Sweden Stayed Open. A Deadly Month Shows the Risks. New York Times: Coronavirus, May 15, 2020
- Taiwan beat covid-19 and won friends. At the WHO, it’s still fighting for a seat at the table. Washington Post: Coronavirus, May 15, 2020
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Business and Economic News
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Business News
- Antibody Testing For Covid-19: Oxford Academic Journals: Coronavirus, May 15, 2020
- Physician deaths from corona virus (COVID-19) disease Oxford Academic Journals: Coronavirus, May 15, 2020
- Countries Slammed Their Borders Shut To Stop Coronavirus. But Is It Doing Any Good? NPR: Health, May 15, 2020
Economics Blogs
- The labour market policy response to COVID-19 must leverage the power of age VoxEU.org, May 15, 2020
- Consumer responses to the COVID-19 crisis VoxEU.org, May 15, 2020
- Covid social distancing is driven mostly by voluntary demobilisation VoxEU.org, May 15, 2020
Top Economics News
- Brazil coronavirus cases hit daily record as Bolsonaro pressures CEOs - Reuters India (Brazilian Economy), May 15, 2020
- Seven weeks into coronavirus lockdowns, Fed has a new, darker message Jerome Powell (Reuters), May 14, 2020
- Trump cheers Wisconsin ruling as tensions flare over coronavirus lockdowns - Reuters (Trump Economy), May 14, 2020
- UK follows EU, U.S. to approve Roche COVID-19 antibody tests US Economy (Reuters), May 14, 2020
- France says any Sanofi COVID-19 vaccine for the world, no favourites US Economy (Reuters), May 14, 2020
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Law Technology
- COVID-19 linked to 30-fold increase in rare childhood inflammatory disease Ars Technica, May 15, 2020
- COVID-19 online fraud trends: Industries, schemes and targets Help Net Security, May 15, 2020
- The COVID-19 misinformation crisis is just beginning, but there is hope Ars Technica, May 14, 2020
Legal Administrator
- Coronavirus: Help Line Launched to Support Mental Health of Physicians EntertainHR, May 15, 2020
- U.S. Department of Labor Issues Alert to Keep Nursing Home and Long-Term Care Facility Workers Safe During Coronavirus Pandemic OSHA News Releases, May 14, 2020
- New IRS Guidance Allows Employers More Flexibility For Benefits Plans During COVID-19 Crisis Tax Girl Blog, May 14, 2020
Librarian News
- American Library Association Press Release: Business, government, education leaders call for emergency funding for libraries impacted by COVID-19 House of Butter, May 15, 2020
- UK:Law centres invited to apply for grants from £5m coronavirus pot House of Butter, May 15, 2020
- Seton Hall Law School Offers New Course on COVID-19 Law and Policy House of Butter, May 15, 2020
Leading Law Departments
- What Asia’s COVID-19 Experience Suggests for the West’s Return to Work Inside Counsel, May 14, 2020
- Post-COVID-19: What to Expect in the 'Next Normal' Inside Counsel, May 14, 2020
- Companies Pledge To Forego IP Rights For Covid Projects Today's General Counsel: Career, May 14, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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