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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
4,966,114 |
323,635 |
| US |
1,565,219 |
93,157 |
Research News
SUMMARY
- An analysis of T-cell response** in patients with mild symptoms suggests that past exposure to other coronaviruses may play an important role in limiting disease related to SARS-CoV-2. If so, it might help explain why children, with frequent exposure to coronaviruses and their parents (i.e., younger adults) are less affected by the disease.
- Conjunctivitis was a frequent symptom of COVID-19 in China and should be considered both as a suggestive symptom and indicative of a possible path of entry for the virus.
- Low platelet count was also frequently associated with COVID-19 in hospitalized cases and was a bad prognostic factor.
- The ACE2 receptor, a key target of SARS-CoV-2, is widely distributed in the brain** of mice and humans and suggests that there is a broad range of potential neurological effects from COVID-19.
- SARS-CoV-2 was isolated in the feces of 43% of patients studied and the virus from those samples was infectious in cell culture. This reinforces the notion that fecal oral spread is possible in this population.
- A pooled analysis of cases with clearly identified exposures to SARS-CoV-2 found a mean incubation period of 5.5 days with 95% of cases falling between 2.1 and 14.7 days. We can expect 1% of infections to have incubation periods beyond 14 days. (Note that this does not consider mildly symptomatic cases which might have longer incubation periods.)
- A study of anonymous Apple mobility data in Japan suggests that a change of only 11% in mobility might be sufficient to reduce R(t) below 1.0. If this is true, it implies that mask wearing and other behavioral changes may be far more important than limiting mobility to control spread of SARS-CoV-2.
- An analysis of case fatality rates (CFR) in local areas of Korea** found values ranging from 1.7% to 25.9%. A closer analysis concluded that these rates are heavily influenced by nursing home outbreaks and should be interpreted with caution.
* * * * *
*Preprint **Not peer reviewed.
- Covid19- Ahead of the Curve.
* * * * *
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Clinical Laboratory and Diagnostics
- Highly sensitive and full-genome interrogation of SARS-CoV-2 using multiplexed PCR enrichment followed by next-generation sequencing bioRxiv: The Preprint Server for Biology (Covid), May 19, 2020
- Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques ( bioRxiv: The Preprint Server for Biology (Covid), May 18, 2020
- Interpretable Artificial Intelligence for COVID-19 Diagnosis from Chest CT Reveals Specificity of Ground-Glass Opacities MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Infection Control
- Transmission of aerosols through pristine and reprocessed N95 respirators MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- The impact of testing and infection prevention and control strategies on within-hospital transmission dynamics of COVID-19 in English hospitals MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Distributions and risks of SARS-CoV-2 in hospital outdoor environment MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Clinical Case Management
- Sarilumab use in severe SARS-CoV-2 pneumonia MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- A stochastic, individual-based model for the evaluation of the impact of non-pharmacological interventions on COVID-19 transmission in Slovakia MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Study of Non-Pharmacological Interventions on COVID-19 Spread MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- COVID-19 as a cardiovascular disease: the potential role of chronic endothelial dysfunction Oxford Academic Journals: Coronavirus, May 18, 2020
- Dynamic relationship between D‐dimer and COVID‐19 severity Wiley: Coronavirus Research & News, May 19, 2020
ICU Care
- Patients with Sickle cell disease and suspected COVID‐19 in a pediatric ICU Wiley: Coronavirus Research & News, May 19, 2020
- Neurologically Devastating Intraparenchymal Hemorrhage in COVID-19 Patients on Extracorporeal Membrane Oxygenation: A Case Series Oxford Academic Journals: Coronavirus, May 19, 2020
Clinical Course and Outcomes
- Protracted course of coronavirus disease with severe acute respiratory distress syndrome: a case report Wiley: Coronavirus Research & News, May 19, 2020
- Evans syndrome in a patient with COVID‐19 Wiley: Coronavirus Research & News, May 19, 2020
- Human coronavirus reinfection dynamics: lessons for SARS-CoV-2 MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Impact on Other Specialties
- Prevision of multidisciplinary head and neck cancer survivorship care during the 2019 novel coronavirus pandemic Wiley: Coronavirus Research & News, May 19, 2020
- Is physiotherapy ready for the management of COVID‐19 in Africa? – Snippets of anecdotal evidences in two African countries Wiley: Coronavirus Research & News, May 19, 2020
- Successful prevention and screening strategies for COVID‐19: focused on patients with hematologic diseases Wiley: Coronavirus Research & News, May 19, 2020
Reviews, Commentary, and Miscellaneous
- The coronavirus hit us strong: a small‐scale narrative Wiley: Coronavirus Research & News, May 19, 2020
- Overlapping values: religious and scientific conflicts during the COVID‐19 crisis in Brazil Wiley: Coronavirus Research & News, May 19, 2020
- Rethinking states of emergency Wiley: Coronavirus Research & News, May 19, 2020
Mental Health
- Is it Just About Physical Health? An Internet-Based Cross-Sectional Study Exploring the Psychological Impacts of COVID-19 Pandemic on University Students in Jordan Using Kessler Psychological Distress Scale MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Mental wellbeing in the Bangladeshi healthy population during nationwide lockdown over COVID-19: an online cross-sectional survey MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- What can psychiatrists learn from SARS and MERS outbreaks? Lancet: COVID-19 Resource Centre (Covid), May 18, 2020
- Predictions of Covid-19 Related Unemployment On Suicide and Excess Mortality in the United States MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Rising Tide: Responding to the Mental Health Impact of the COVID‐19 Pandemic Wiley: Coronavirus Research & News, May 19, 2020
- Psychological Distress during the COVID-19 pandemic in France: a national assessment of at-risk populations MedRxiv Server for Health Sciences: Coronavirus, May 19, 2020
Drug Development
- Molecular Targets for the Testing of COVID‐19 Wiley: Coronavirus Research & News, May 19, 2020
- Repurposing of Miglustat to inhibit the coronavirus Severe Acquired Respiratory Syndrome SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), May 19, 2020
- Repurposing Simeprevir, Calpain Inhibitor IV and a Cathepsin F Inhibitor Against SARS-CoV-2: A Study Using in Silico Pharmacophore Modeling and Docking Methods ChemRxiv (Covid), May 18, 2020
Newly Registered Clinical Trials
- Oral Manifestation of COVID 19 Patient: A Cross Sectional Study on Egyptian Population May 18, 2020
- Inhaled Nitric Oxide for Preventing Progression in COVID-19 May 18, 2020
- Cold Laser Therapy for COVID-19 Positive Patients With Pulmonary Disease May 18, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Controlling the SARS-CoV-2 Spike Glycoprotein Conformation bioRxiv: The Preprint Server for Biology (Covid), May 19, 2020
- Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? bioRxiv: The Preprint Server for Biology (Covid), May 19, 2020
- Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2. bioRxiv: The Preprint Server for Biology (Covid), May 19, 2020
Vaccine Development
- Planning for a COVID-19 Vaccination Program JAMA Network: Coronavirus, May 18, 2020
- Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV): An Unprecedented Partnership for Unprecedented Times JAMA Network: Coronavirus, May 18, 2020
- Will an imperfect vaccine curtail the COVID-19 pandemic in the U.S.? MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Epidemiology
- Epidemiological, socio-demographic and clinical features of the early phase of the COVID-19 epidemic in Ecuador MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- The effect of BCG vaccination on COVID-19 examined by a statistical approach: no positive results from the Diamond Princess and cross-national differences previously reported by world-wide comparisons are flawed in several ways MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Spatial variability in the risk of death from COVID-19 in 20 regions of Italy MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Modeling and Prediction
- Infection Dynamics of Coronavirus Disease 2019 (Covid-19) Modeled with the Integration of the Eyring Rate Process Theory and Free Volume Concept Outbreak Science, May 19, 2020
- Prediction of Coronavirus Disease (covid-19) Evolution in USA with the Model Based on the Eyring Rate Process Theory and Free Volume Concept Outbreak Science, May 19, 2020
- Modeling the impact of social distancing, testing, contact tracing and household quarantine on second-wave scenarios of the COVID-19 epidemic MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Public Health Intervention
- Evaluation of the US governors decision when to issue stay-at-home orders [Running title: When to shut down: the Weber-Fechner law describes the timing of U. S. governors decisions to issue stay-at-home orders] MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Quantitative Analysis of the Effectiveness of Public Health Measures on COVID-19 Transmission MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- The effect of a national lockdown in response to COVID-19 pandemic on the prevalence of clinical symptoms in the population MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Surveillance and sero-epidemiology
- Distinct systems serology features in children, elderly and COVID patients MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- SARS-CoV-2 seroprevalence trends in healthy blood donors during the COVID-19 Milan outbreak MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Estimating seroprevalence with imperfect serological tests: a cutoff-free approach bioRxiv: The Preprint Server for Biology (Covid), May 19, 2020
Other
- SARS-CoV2 infection in farmed mink, Netherlands, April 2020 bioRxiv: The Preprint Server for Biology (Covid), May 19, 2020
- Mining Twitter Data on COVID-19 for Sentiment analysis and frequent patterns Discovery MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- COVID-19 pandemic: every day feels like a weekday to most MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- The medical education level of the administrators of the local health committees in China MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- How the COVID-19 pandemic is favoring the adoption of digital technologies in healthcare: a literature review MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- The Response in Air Quality to the Reduction of Chinese Economic Activities during the COVID‐19 Outbreak Wiley: Coronavirus Research & News, May 19, 2020
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Coronavirus Research Resources
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China
- The medical education level of the administrators of the local health committees in China MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Mixed Chinese herbs and Western medicine for novel coronavirus disease 2019 (COVID-19): a mixed method review MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Pompeo Blasts WHO And China For Excluding Taiwan From This Week's Health Assembly NPR: Health, May 18, 2020
South Korea
- Association of previous medications with the risk of COVID-19: a nationwide claims-based study from South Korea MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Treatment Response to Hydroxychloroquine, Lopinavir/Ritonavir, and Antibiotics for Moderate COVID 19: A First Report on the Pharmacological Outcomes from South Korea MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Italy
- Spain Lifts Direct Ban on Flights From Italy New York Times: Coronavirus, May 19, 2020
- Spatial variability in the risk of death from COVID-19 in 20 regions of Italy MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- COVID-19 outbreak in Italy: estimation of reproduction numbers over two months toward the Phase 2 MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- ATHENS, Greece (AP) — Europe reopened more widely on Monday, allowing people into the Acropolis in Athens, high-fashion boutiques in Italy, museums in Belgium, golf courses in Ireland and beer... AP Health News: Coronavirus, May 18, 2020
Spain
- Spain Lifts Direct Ban on Flights From Italy New York Times: Coronavirus, May 19, 2020
- Effects of mobility and multi-seeding on the propagation of the COVID-19 in Spain MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
- Chasing the ghost of infection past: identifying thresholds of change during the COVID-19 infection in Spain MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Germany
- Germany, France Propose $543 Billion EU Coronavirus Recovery Fund NPR: Health, May 19, 2020
France
- Psychological Distress during the COVID-19 pandemic in France: a national assessment of at-risk populations MedRxiv Server for Health Sciences: Coronavirus, May 19, 2020
- Germany, France Propose $543 Billion EU Coronavirus Recovery Fund NPR: Health, May 19, 2020
United Kingdom
- Accessibility and allocation of public parks and gardens during COVID-19 social distancing in England and Wales MedRxiv Server for Health Sciences: Coronavirus, May 18, 2020
Other International News
- ATHENS, Greece (AP) — More than a century ago, the Sotiria hospital in Athens was built as a public sanatorium for patients with a feared infectious disease that spread through coughing and killed... AP Health News: Coronavirus, May 19, 2020
- Trump’s use of malaria drug likely to be welcomed in India AP Health News: Coronavirus, May 19, 2020
- GALLUP, N.M. (AP) — On the eve of New Mexico's shutdown of bars and restaurants to stem the spread of the coronavirus, the city of Gallup came alive for one last night of revelry. AP Health News: Coronavirus, May 19, 2020
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Business and Economic News
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Business News
- Scared To Return To Work, Or Can't With Kids At Home? Here's What You Need To Know NPR: Health, May 19, 2020
- Traffic Is Way Down, Due To Lockdowns, But Air Pollution? Not So Much NPR: Health, May 19, 2020
- What To Say When A Friend Is Struggling NPR: Health, May 19, 2020
Economics Blogs
- Gauging the impact of COVID-19 on market-based inflation expectations VoxEU.org, May 19, 2020
- COVID-19 in Italy: An analysis of death registry data, part II VoxEU.org, May 19, 2020
- Bernie Sees COVID-19 "Silver Lining" - Will Change "Fundamental Tenets" Of America Zero Hedge, May 18, 2020
- Modeling the Global Effects of the COVID-19 Sudden Stop in Capital Flows Liberty Street Economics, May 18, 2020
Top Economics News
- Coronavirus latest: Trump threatens to permanently defund WHO - DW (English) (Trump Economy), May 19, 2020
- Mnuchin And Fed's Powell Set To Brief Senators On $2 Trillion Coronavirus Act NPR: Economy, May 19, 2020
- Powell, Mnuchin to face Senate grilling on U.S. coronavirus response Jerome Powell (Reuters), May 19, 2020
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Law Technology
- Apple And Google Set To Release Coronavirus API Amidst Privacy Furore Silicon UK, May 19, 2020
- Microsoft open-sources coronavirus threat data Information Security Buzz, May 19, 2020
- Ceteris Paribus: COVID-19, Global Trade and the Evolving International Supply Chain Legal Executive Institute: Events, May 18, 2020
Legal Administrator
- Bringing Them Back: Onboarding After COVID-19 EntertainHR, May 19, 2020
- Perspective: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, May 18, 2020
- Latest ACC Flash Poll Examines Impact of COVID-19 on Education and Training for Over 400 In-House Lawyers ACC News, May 18, 2020
- Associates Report On The Unprecedented Challenge Of COVID-19 [Sponsored] Above the Law - Big Law, May 18, 2020
- ICYMI: U.S. Department of Labor Acts to Help American Workers And Employers During the Coronavirus Pandemic OSHA What's New, May 18, 2020
Librarian News
- COVID-19 NEWS: 'Reopening Libraries in New Zealand: Slow and Steady Wins the Race' Information Today: News Breaks, May 19, 2020
- COVID-19 NEWS: 'Libraries Around the World Prepare for a New Normal' Information Today: News Breaks, May 19, 2020
- COVID-19 NEWS: 'FlatWorld Announces Textbooks Will Include COVID-19 Updates for Fall Semester' Information Today: News Breaks, May 19, 2020
Leading Law Departments
- Perspective: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, May 18, 2020
- The Fire Next Time? CFOs Say Contingency Plans Lacking for Covid-19 2nd Wave CorporateCounsel.net Blog, May 18, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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