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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
5,389,955 |
343,467 |
| US |
1,665,908 |
98,652 |
How Can We Be More Like Vietnam?: The Critical COVID-19 Question We Should Be Asking When it comes to controlling the COVID-19 pandemic, nobody did better than Vietnam. What did they do and how can we do the same thing?
Research News
SUMMARY
- Studies of mask use in China** and of preventive behavior in Vietnam** during the pandemic found that 99.7% and 99.5% of subjects wore masks. This near universal use of masks sharply contrasts with the limited use of masks in the United States and may be an important part of the explanation for why those countries managed the COVID-19 pandemic so much better than the US.
- An exhaustive meta-analysis of clinical trials** and a registry study both found strong evidence that the use of hydroxychloroquine confers no beneficial effects and is associated with an increase in adverse reactions in COVID-19 patients. Taken together, these studies suggest that the continued use of hydroxychloroquine in this context should be considered medical malpractice.
- Expression of the gene for the ACE2 receptor, the target for the SARS-CoV-2 spike protein, increases with age and is dramatically lower in young children suggesting a potential explanation for the lower rate of severe disease in younger age groups.
- An analysis of human breast milk from two mothers with COVID-19 found SARS-CoV-2 in repeated samples from one mother.
- A study of a Seattle nursing home found that a coordinated public health intervention combining isolation, protective measures, and testing effectively contained the outbreak. This model should be studied as a standard for proactive prevention of COVID-19 at nursing homes and assisted living communities nationwide.
- Autopsies of 8 COVID-19 victims found SARS-CoV-2 (by immunohistochemistry) in the lungs and airways, but nowhere else, despite evidence of effects related to multiple organ systems. Given the growing belief that this is a multi-system disease, these findings have major implications, particularly if borne out by additional studies.
- The shift in the growth rate epidemic curves** of countries around the world following the introduction of public health interventions suggests that more than 60 million confirmed cases of COVID-19 were averted by these measures, which, given the current global rate of fatalities per confirmed case of 6.8%, translates to more than 4 million deaths averted worldwide.
- An analysis of 15,000 SARS-CoV-2 genomes** found none that were convincingly associated with increased viral transmission. It appeared that recurrent mutations are either neutral or weakly deleterious.
- Sequencing B cell receptor repertoires** from COVID-19 patients has generated a library of 777 antibody clones in reaction to the virus which should provide a foundation for further studies related to vaccines and immunotherapy.
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*Preprint **Not peer reviewed.
- Covid19- Ahead of the Curve.
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Clinical Laboratory and Diagnostics
- Development and Validation of Two In-house, Low-Cost SARS-CoV-2 Detection Assays MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- TMPRSS2: Potential Biomarker for COVID‐19 Outcomes Wiley: Coronavirus Research & News, May 22, 2020
- Rapid Isothermal Amplification and Portable Detection System for SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), May 22, 2020
Emergency Care and Triage
- COVID‐19 Pandemic and Shortage of Personal Protective Equipment in Tokyo Clinics Wiley: Coronavirus Research & News, May 21, 2020
- Use of a plastic barrier curtain to minimize droplet transmission during tracheal extubation in patients with coronavirus disease Wiley: Coronavirus Research & News, May 21, 2020
- Novel coronavirus COVID-19: an overview for emergency clinicians. NIH: National Library of Medicine: Coronavirus, May 20, 2020
- Development and validation of chest CT-based imaging biomarkers for early stage COVID-19 screening MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
Infection Control
- Aerosol Risk with Noninvasive Respiratory Support in Patients with COVID‐19 Wiley: Coronavirus Research & News, May 22, 2020
- Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals bioRxiv: The Preprint Server for Biology (Covid), May 22, 2020
- Feasibility of Reusing Surgical Mask Under Different Disinfection Treatments MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
- Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19 Lancet: COVID-19 Resource Centre (Covid), May 20, 2020
- Simulated Sunlight Rapidly Inactivates SARS-CoV-2 on Surfaces Oxford Academic Journals: Coronavirus, May 20, 2020
- Assessment of dispersion of airborne particles of oral/nasal fluid by high flow nasal cannula therapy MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
Clinical Case Management
- “Care for patients with ventricular assist devices and suspected COVID‐19 infection” Wiley: Coronavirus Research & News, May 22, 2020
- Modified percutaneous tracheostomy in COVID‐19 critically ill patients Wiley: Coronavirus Research & News, May 22, 2020
- Technological devices in COVID-19 primary care management: the Italian experience Oxford Academic Journals: Coronavirus, May 22, 2020
ICU Care
- ICU Bed Availability Monitoring and analysis in the Grand Est region of France during the COVID-19 epidemic MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- Performance of progressive and adaptive COVID-19 exit strategies: a stress test analysis for managing intensive care unit rates MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
Clinical Course and Outcomes
- Clostridiodes difficile in COVID-19 Patients, Detroit, Michigan, USA, March–April 2020 CDC: Emerging Infectious Diseases, May 22, 2020
- Clinical characteristics and early outcomes in patients with COVID-19 treated with tocilizumab at a United States academic center Outbreak Science, May 22, 2020
- Epidemiological and clinical characteristics of discharged patients infected with SARS‐CoV‐2 on the Qinghai plateau Wiley: Coronavirus Research & News, May 22, 2020
Impact on Other Specialties
- Laser‐assisted head and neck surgery in the COVID‐19 pandemic: controversial evidence and precautions Wiley: Coronavirus Research & News, May 22, 2020
- Ambulatory Care Practice in the COVID‐19 Era: Redesigning Clinical Services and Experiential Learning Wiley: Coronavirus Research & News, May 22, 2020
- Clinical and Psychological Issues in Children with Inflammatory Bowel Disease During COVID-19 Pandemic Oxford Academic Journals: Coronavirus, May 22, 2020
Reviews, Commentary, and Miscellaneous
- Care in the time of coronavirus: Ethical considerations in head and neck oncology Wiley: Coronavirus Research & News, May 22, 2020
- Intuitive Global Insight Into COVID‐19 Clinical Research Activities—The “COVID‐19 Map of Hope” Wiley: Coronavirus Research & News, May 22, 2020
- Coronavirus disease 2019 (COVID-19): A literature review. NIH: National Library of Medicine: Coronavirus, May 22, 2020
Mental Health
- Dreaming during the Covid-19 pandemic: Computational assessment of dream reports reveals mental suffering associated with negative feelings and contagion fear MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- Offline: Health in the unhappy time of COVID-19 Lancet: COVID-19 Resource Centre (Covid), May 21, 2020
- Who is lonely in lockdown? Cross-cohort analyses of predictors of loneliness before and during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
Drug Development
- The Potential of Memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID‐19, including ARDS and to reduce viral replication through lysosomal effects Wiley: Coronavirus Research & News, May 22, 2020
- Baricitinib: a chance to treat COVID‐19? Wiley: Coronavirus Research & News, May 22, 2020
- Will Serious Shortage Protocols help ease drug shortages? Wiley: Coronavirus Research & News, May 22, 2020
Newly Registered Clinical Trials
- Study of the Safety of Therapeutic Tx With IMMUNOMODULATORY MSC in Adults With COVID-19 Infection Requiring Mechanical Ventilation May 21, 2020
- COVID-19: Study of INFLAmmasome and PLAtelets Functions May 21, 2020
- COVID-19 PEP- High-risk Individuals in Long-term and Specialized Care - Canada May 21, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Response to “Comments on "Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross‐species transmission from snake to human” and “Codon bias analysis alone is uninformative for identifying host(s) of new virus” Wiley: Coronavirus Research & News, May 22, 2020
- Simulating Chalcogen Bonding Using Molecular Mechanics: A Pseudoatom Approach to Model Ebselen. ChemRxiv (Covid), May 22, 2020
- Computational Analysis of Dynamic Allostery and Control in the SARS-CoV-2 Main Protease bioRxiv: The Preprint Server for Biology (Covid), May 22, 2020
Vaccine Development
- COVID‐19 vaccines: knowing the unknown Wiley: Coronavirus Research & News, May 22, 2020
- [Strategies for vaccine development of COVID-19]. NIH: National Library of Medicine: Coronavirus, May 22, 2020
- Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Alum Induces Protective Immunity and Reduces Immune Enhancement bioRxiv: The Preprint Server for Biology (Covid), May 22, 2020
Epidemiology
- Increase in Covid‐19 Cases and Case Fatality and Case Recovery Rates in Europe: A Cross Temporal Meta‐Analysis Wiley: Coronavirus Research & News, May 22, 2020
- The epidemiology and clinical information about COVID-19. NIH: National Library of Medicine: Coronavirus, May 22, 2020
- COVID‐19 suspicion and diagnosis: are we still chasing epidemiological criteria? Wiley: Coronavirus Research & News, May 22, 2020
Modeling and Prediction
- An Evaluation of Mathematical Models for the Outbreak of COVID-19 Oxford Academic Journals: Coronavirus, May 22, 2020
- Multivariate Prediction Network Model for epidemic progression to study the effects of lockdown time and coverage on a closed community on theoretical and real scenarios of COVID-19. MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- Mathematical Modeling and Simulation of SIR Model for COVID−2019 Epidemic Outbreak: A Case Study of India MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
Public Health Intervention
- Partial unlock for COVID-19-like epidemics can save 1-3 million lives worldwide MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- Prescribing Paid Sick Leave—An Important Tool for Primary Care During the Pandemic JAMA Network: Coronavirus, May 21, 2020
- Early assessment of knowledge, attitudes, anxiety and behavioral adaptations of Connecticut residents to COVID-19 MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
Surveillance and sero-epidemiology
- Changes in RT-PCR-positive SARS-CoV-2 rates in adults and children according to the epidemic stages MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- Detection of SARS-CoV-2 in pets living with COVID-19 owners diagnosed during the COVID-19 lockdown in Spain: A case of an asymptomatic cat with SARS-CoV-2 in Europe MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- Modeling serological testing to inform relaxation of social distancing for COVID-19 control MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
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Coronavirus Research Resources
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China
- BEIJING (AP) — China doubled down Friday on efforts to combat the coronavirus pandemic and create jobs as the number of people thrown out of work soars worldwide. AP Health News: Coronavirus, May 22, 2020
- Stocks end lower on Wall Street as US-China tensions weigh AP Health News: Coronavirus, May 22, 2020
- The epidemiological characteristics of 2019 novel coronavirus diseases (COVID-19) in Jingmen,Hubei,China MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
Iran
- TEHRAN, Iran (AP) — The coronavirus has infected more than 10,000 health care workers in hard-hit Iran, news outlets reported Thursday. In southern Yemen, the virus-related death toll at a... AP Health News: Coronavirus, May 21, 2020
- COVID-19 Infection Forecasting based on Deep Learning in Iran MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
- Iran Extends Zaghari-Ratcliffe's Temporary Release, Lawyer Says New York Times: Coronavirus, May 20, 2020
South Korea
- South Korea's May 1-20 Exports Tumble 20.3%, Rate Slower Than April New York Times: Coronavirus, May 20, 2020
- Monitoring the evolution of the COVID-19 pandemic in China, South Korea, Italy and USA through the net relative rate of infection of the total number of confirmed cases MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
- SEOUL, South Korea (AP) — South Korean students began returning to classes Wednesday as the country counted 32 new coronavirus cases. It was the first time in nine days that the daily... AP Health News: Coronavirus, May 20, 2020
- SEOUL, South Korea (AP) — South Korean students began returning to school on Wednesday, but not without some hitches, in a possible template for other countries struggling to reopen educational... AP Health News: Coronavirus, May 20, 2020
Italy
- Technological devices in COVID-19 primary care management: the Italian experience Oxford Academic Journals: Coronavirus, May 22, 2020
- Monitoring the evolution of the COVID-19 pandemic in China, South Korea, Italy and USA through the net relative rate of infection of the total number of confirmed cases MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
- ROME (AP) — Italy's restaurants and pizzerias, for foodies the world over a key reason to visit, are facing an existential threat. Those that didn't fold after 10 weeks of a strict coronavirus... AP Health News: Coronavirus, May 20, 2020
Spain
- Detection of SARS-CoV-2 in pets living with COVID-19 owners diagnosed during the COVID-19 lockdown in Spain: A case of an asymptomatic cat with SARS-CoV-2 in Europe MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- Search for asymptomatic carriers of SARS-CoV-2 in healthcare workers during the pandemic: a Spanish experience MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
Germany
- DRESDEN, Germany (AP) — A fourth player at German soccer club Dynamo Dresden tested positive for the coronavirus on Thursday. The already quarantined second-division club said on its website... AP Health News: Coronavirus, May 21, 2020
- Flatten the Curve! Modeling SARS-CoV-2/COVID-19 Growth in Germany on the County Level MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
- Germany Struggles To Fill Its Farm Labor Shortage After Closing Its Borders NPR: Health, May 20, 2020
France
- ICU Bed Availability Monitoring and analysis in the Grand Est region of France during the COVID-19 epidemic MedRxiv Server for Health Sciences: Coronavirus, May 21, 2020
- Monitoring and predicting SARS-CoV-2 epidemic in France after deconfinement using a multiscale age-stratified rate model MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
- COVID-19: Spatial Analysis of Hospital Case-Fatality Rate in France MedRxiv Server for Health Sciences: Coronavirus, May 20, 2020
United Kingdom
- LONDON (AP) — British researchers testing an experimental vaccine against the new coronavirus are moving into advanced studies and aim to immunize more than 10,000 people to determine if the shot... AP Health News: Coronavirus, May 22, 2020
- Britain in Deepest Downturn for Centuries, Scant Chance of Negative Rates: Reuters Poll New York Times: Coronavirus, May 21, 2020
- Golf returns to England and Wales — for those who don’t mind golfing alone Washington Post: Coronavirus, May 21, 2020
Other International News
- Rights group: Egypt arrested 10 reporters since virus hit AP Health News: Coronavirus, May 22, 2020
- Sweden is still nowhere near 'herd immunity,' even though it didn't go into lockdown CNN.com - Health, May 21, 2020
- EL CENTRO, Calif. (AP) — As much of California begins reopening businesses amid improved coronavirus conditions, a farming region on the state's border with Mexico is experiencing a spike in... AP Health News: Coronavirus, May 21, 2020
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Business and Economic News
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Business News
- An Evaluation of Mathematical Models for the Outbreak of COVID-19 Oxford Academic Journals: Coronavirus, May 22, 2020
- Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19). NIH: National Library of Medicine: Coronavirus, May 22, 2020
- Rodent Control CDC: Coronavirus Disease: What's New, May 22, 2020
Economics Blogs
- The euro area in the age of COVID-19 VoxEU.org, May 22, 2020
- Trade conflict in the age of Covid-19 VoxEU.org, May 22, 2020
- Covid-19 and the option value of waiting VoxEU.org, May 22, 2020
Top Economics News
- Fox News Poll: Biden more trusted on coronavirus, Trump on economy - Fox News (Trump Economy), May 21, 2020
- Fed, Treasury still have 'ammunition' to help coronavirus-ravaged economy: Trump - Reuters (Trump Economy), May 21, 2020
- U.S. secures 300 million doses of potential AstraZeneca COVID-19 vaccine US Economy (Reuters), May 21, 2020
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Law Technology
- Chronology of COVID-19 Phish Found in Environments Protected by Proofpoint During the Pandemic Phish Me, May 22, 2020
- COVID-19 Impact on the California Courts American LegalNet Blog, May 22, 2020
- The State of E-Discovery 2020: 3rd Annual Report Finds Legal Budget Impacts Stretch Beyond COVID-19 - GlobeNewswire (eDiscovery), May 21, 2020
Legal Administrator
- Recruitment Best Practices During COVID-19 EntertainHR, May 22, 2020
- Let’s Not Lose Ground During COVID-19 In The Fight For Gender Equality In Law Firms Above the Law - Big Law, May 21, 2020
- COVID-19 Privacy Protection and Persecuted Minorities HeyDataData: Womble, May 21, 2020
Librarian News
- Coronavirus crisis has humanised law firms says Mallesons head honcho House of Butter, May 22, 2020
- LexBlog: A Major Legal Publisher Adds Local COVID-19 Ordinances and Orders House of Butter, May 22, 2020
- LexBlog Article: India’s Supreme Court’s Continuous Battle with Covid-19 House of Butter, May 22, 2020
Leading Law Departments
- Non-GAAP: Are Companies Adjusting Away Covid-19? CorporateCounsel.net Blog, May 21, 2020
- Guest Post: Spurring and Clearing the Path for Open COVID Innovation Through Contextual Patent Disclosure Patently-O - Dennis Crouch, May 20, 2020
- Law Firm Revenue Takes Nosedive During COVID-19 Inhouse Blog, May 20, 2020
- Covid Litigation Dog Not Barking Today's General Counsel: Career, May 20, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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