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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
5,631,824 |
348,965 |
| US |
1,710,558 |
99,928 |
Memorial Day and the War on Science The victims in the War on Science are all around us. We must remember them and resolve never to let it happen again. Science is not a point of view, it is a determination to find the objective truth. Only its denial reveals a point of view and a determination to mislead on behalf of an agenda, regardless of the cost.
Research News
A study of the transcriptional response of cells infected by SARS-CoV-2 found that the virus appears to inhibit the initial cellular response, but elevates the subsequent inflammatory response. The unique immune response provoked by the virus helps to explain the relative absence of early symptoms as well as the severity of subsequent symptoms.
A scoring system for assessing COVID-19 vulnerability converts the subject age based on demographics and comorbidity to determine a risk adjusted age. A system such as this can be used to assess individualized worker risk and determine appropriate levels of protection.
In a quantitative review of studies of SARS-CoV-2 transmission, the authors conclude that the number of close, personal interactions is more important than proximity, particularly at meals (without masks). Masks substantially reduce risk in closed spaces such as elevators and trains. Most spreading events studied involved asymptomatic carriers.
A meta-analysis of key parameters related to transmission of SARS-CoV-2 estimated a secondary attack rate of 15.4% in household settings with rates that rose by a factor of 2.6 for symptomatic cases. The serial interval was estimated as 4.9 days and the asymptomatic infection rate was 26%. In other words, cases are infectious for almost 5 days without symptoms and contagiousness is increased with the arrival of symptoms.
A meta-analysis of asymptomatic infection rates found that only 6 of 270 potentially relevant studies were methodologically appropriate and those studies found that only 11% of cases were truly asymptomatic. These findings suggest that a small minority cases are truly asymptomatic, contradicting the widely held belief that >80% of cases have no symptoms.
A study of antibodies to the SARS-CoV-2 spike protein (S) found that even some subjects without exposure to the virus had high levels of anti-S antibodies and that these antibodies had cross-reactivity with other common pathogens. In other words, antibodies to other viruses may confer some level of immunity to COVID-19.
A study of readmission for COVID-19 in New York City found that 3.6% of patients returned for emergency care after discharge and 1.9% required readmission. The readmitted patients tended to have a shorter length of original stay and higher rates of hypertension. In general, readmission is rare for COVID-19.
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*Preprint **Not peer reviewed.
Covid19- Ahead of the Curve.
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Top News
- ASSESSMENT OF WORKERS PERSONAL VULNERABILITY TO COVID-19 USING COVID-AGE MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Eat, Pray, Work: A meta-analysis of COVID-19 Transmission Risk in Common Activities of Work and Leisure MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- What do we know about SARS-CoV-2 transmission? A systematic review and meta-analysis of the secondary attack rate, serial interval, and asymptomatic infection MedRxiv Server for Health Sciences: Coronavirus, May 23, 2020
- A Rapid Review of the Asymptomatic Proportion of PCR-Confirmed SARS-CoV-2 Infections in Community Settings MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19 MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
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Clinical Laboratory and Diagnostics
- Differences of clinical and imaging findings in multiple generations of secondary COVID-19 infection in Xi'an, China MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- A systems approach to inflammation identifies therapeutic targets in SARS-CoV-2 infection MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
Emergency Care and Triage
- C-Reactive protein and SOFA score as early predictors of critical care requirement in patients with COVID-19 pneumonia in Spain. MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Early risk assessment for COVID-19 patients from emergency department data using machine learning MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
Infection Control
- The "Double Eights Mask Brace" Improves the Fit and Protection and Protection of a Basic Surgical Mask Amidst Covid-19 Pandemic MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Quantification of SARS-CoV-2 and cross-assembly phage (crAssphage) from wastewater to monitor coronavirus transmission within communities MedRxiv Server for Health Sciences: Coronavirus, May 23, 2020
- High Filtration Efficiency Face Masks made from Sterilization Wraps MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Risk of COVID-19 among frontline healthcare workers and the general community: a prospective cohort study MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
Clinical Case Management
- Comparison of renin-angiotensin-aldosterone system inhibitors with other antihypertensives in association with coronavirus disease-19 clinical outcomes: systematic review and meta-analysis MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Doxycycline and Hydroxychloroquine as Treatment for High-Risk COVID-19 Patients: Experience from Case Series of 54 Patients in Long-Term Care Facilities MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Clinical predictors of COVID-19 mortality MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
ICU Care
- Acute Pulmonary Embolism in Critically Ill Patients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Do COVID-19 patients admitted to the ICU require anti-Pneumocystis jirovecii prophylaxis? MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Open-source 3D printed Ventilation Device bioRxiv: The Preprint Server for Biology (Covid), May 23, 2020
Clinical Course and Outcomes
- Hydroxychloroquine and Tocilizumab Therapy in COVID-19 Patients - An Observational Study MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Association between comorbidities and the risk of death in patients with COVID-19: sex-specific differences MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- COVID-19 Outcomes in 4712 consecutively confirmed SARS-CoV2 cases in the city of Madrid. MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
Impact on Other Specialties
- IBD in the Times of COVID-19 Oxford Academic Journals: Coronavirus, May 25, 2020
- Good communication is critical to supporting people living and working with a rare disease: current rare disease support perceived as inadequate. MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- The effects of the COVID-19 pandemic on oncological surgery Oxford Academic Journals: Coronavirus, May 22, 2020
Reviews, Commentary, and Miscellaneous
- Letter to the Editor: Our Response to Covid-19 as Endocrinologists and Diabetologists Oxford Academic Journals: Coronavirus, May 25, 2020
- COVID-19 (Novel Coronavirus 2019) - recent trends. NIH: National Library of Medicine: Coronavirus, May 25, 2020
- Rate Estimation and Identification of COVID-19 Infections: Towards Rational Policy Making During Early and Late Stages of Epidemics MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
Mental Health
- Dramatic reduction of psychiatric emergency consultations during lockdown linked to COVID-19 in Paris and suburbs MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Factors Contributing to Healthcare Professional Burnout During the COVID-19 Pandemic: A Rapid Turnaround Global Survey MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Prevalence of Mental Health Problems During Virus Epidemics in the General Public, Health Care Workers and Survivors: A Rapid Review of the Evidence MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Mental distress of adults in Brazil during the COVID-19 crisis MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Psychological Impact of COVID-19 on Pakistani University Students and How They Are Coping MedRxiv Server for Health Sciences: Coronavirus, May 23, 2020
- Compassion in a time of COVID-19 Lancet: COVID-19 Resource Centre (Covid), May 22, 2020
Drug Development
- COVIDep: A web-based platform for real-time reporting of vaccine target recommendations for SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), May 25, 2020
- Protocol of a randomized controlled trial testing inhaled Nitric Oxide in mechanically ventilated patients with severe acute respiratory syndrome in COVID-19 (SARS-CoV-2). MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Repurposing Existing Medications for Coronavirus Disease 2019: Protocol for a Rapid and Living Systematic Review MedRxiv Server for Health Sciences: Coronavirus, May 23, 2020
Newly Registered Clinical Trials
- Ivermectin-Azithromycin-Cholecalciferol (IvAzCol) Combination Therapy for COVID-19 May 22, 2020
- Evaluation of a Remote Monitoring Smartphone Application and Care Model of COVID-19 Patients in the Community (ReCOVER) May 22, 2020
- Mechanisms of Multi-organ Failure in COVID-19 May 22, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- In silico Proteome analysis of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) bioRxiv: The Preprint Server for Biology (Covid), May 25, 2020
- The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I bioRxiv: The Preprint Server for Biology (Covid), May 25, 2020
- Structural insight into the putative role of novel SARS CoV-2 E protein in viral infection: a potential target for LAV development and therapeutic strategies Outbreak Science, May 24, 2020
Vaccine Development
- Determinants of COVID-19 Vaccine Acceptance in the U.S. MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Multi-epitope based peptide vaccine design against SARS-CoV-2 using its spike protein bioRxiv: The Preprint Server for Biology (Covid), May 23, 2020
- A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation bioRxiv: The Preprint Server for Biology (Covid), May 23, 2020
- Influenza vaccine does not increase the risk of coronavirus or other non-influenza respiratory viruses: retrospective analysis from Canada, 2010-11 to 2016-17 Infectious Diseases Society of America Journals: Coronavirus, May 22, 2020
- Developing Covid-19 Vaccines at Pandemic Speed New England Journal of Medicine: Coronavirus, May 22, 2020
Epidemiology
- Is there an airborne component to the transmission of COVID-19? : a quantitative analysis study MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Geographical surveillance of COVID-19: Diagnosed cases and death in the United States MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Flattening the COVID 19 curve in susceptible forest indigenous tribes using SIR model MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
Modeling and Prediction
- CLINICAL CHARACTERISTICS AND PROGNOSTIC FACTORS FOR ICU ADMISSION OF PATIENTS WITH COVID-19 USING MACHINE LEARNING AND NATURAL LANGUAGE PROCESSING MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- COVID-19 Infection Forecasting based on Deep Learning in Iran MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Predicting SARS-CoV-2 infection trend using technical analysis indicators MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
Public Health Intervention
- SARS-CoV-2 infection in London, England: Impact of lockdown on community point-prevalence, March-May 2020 MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Low Covid-19 hospitalisation in Dumfries and Galloway: comparison with other Scottish health boards MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- SARS-CoV-2 lethality decreased over time in two Italian Provinces MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
Surveillance and sero-epidemiology
- Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Breaking the back of COVID-19: Is Bangladesh doing enough testing? MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Whole nucleocapsid protein of SARS-CoV-2 may cause false positive results in serological assays Oxford Academic Journals: Coronavirus, May 23, 2020
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Coronavirus Research Resources
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China
- Differences of clinical and imaging findings in multiple generations of secondary COVID-19 infection in Xi'an, China MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Explainer: Emerging Get-Tough Consensus Among Trump's China Advisers Tested by Hong Kong Debate New York Times: Coronavirus, May 24, 2020
- Asian Shares Tick Up, Eyes on China-U.S. Trade Relations New York Times: Coronavirus, May 24, 2020
Iran
- COVID-19 Infection Forecasting based on Deep Learning in Iran MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Demographic and Clinical Characteristics of the Severe Covid-19 Infections: First Report from Mashhad University of Medical Sciences, Iran MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Iranian 107-Year-Old Woman Recovers From Coronavirus: Fars New York Times: Coronavirus, May 24, 2020
- Clustering method for spread pattern analysis of corona-virus (COVID-19) infection in Iran MedRxiv Server for Health Sciences: Coronavirus, May 23, 2020
- Virus Lockdown Forces Iran Into Its First Virtual Quds Day New York Times: Coronavirus, May 22, 2020
South Korea
- Transmission onset distribution of COVID-19 in South Korea MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- BANGKOK (AP) — South Korea on Saturday reported 23 fresh coronavirus cases, mostly from the densely populated Seoul area where authorities shut down thousands of nightclubs, bars and karaoke rooms... AP Health News: Coronavirus, May 23, 2020
- South Korean Study Shows No Evidence Recovered COVID-19 Patients Can Infect Others NPR: Health, May 22, 2020
Italy
- SARS-CoV-2 lethality decreased over time in two Italian Provinces MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- With masks and sanitized hands, Italian Catholics return to church Washington Post: Coronavirus, May 24, 2020
- Estimating the size of the COVID-19 outbreak in Italy: Application of an exponential decay model to the weighted and cumulative average daily growth rate MedRxiv Server for Health Sciences: Coronavirus, May 23, 2020
Spain
- C-Reactive protein and SOFA score as early predictors of critical care requirement in patients with COVID-19 pneumonia in Spain. MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- RABAT, Morocco (AP) — It’s a reverse migrant crisis: Moroccan workers trapped in Spain are begging their own government to let them come back home. AP Health News: Coronavirus, May 24, 2020
- BARCELONA, Spain (AP) — Lionel Messi's Barcelona and the rest of the Spanish league can resume play in June after three months of waiting for the coronavirus pandemic to subside. AP Health News: Coronavirus, May 23, 2020
Germany
- BERLIN (AP) — The German economy shrank by 2.2% in the first quarter of the year compared to the same period in 2019 amid a global downturn linked to the coronavirus pandemic. AP Health News: Coronavirus, May 25, 2020
- While U.S. struggles to roll out coronavirus contact tracing, Germany has been doing it from the start Washington Post: Coronavirus, May 25, 2020
- BERLIN (AP) — A German state governor’s proposal to end blanket coronavirus restrictions in his region, which would be a first for the country after a comparatively successful response to the... AP Health News: Coronavirus, May 24, 2020
- The COVID-19 Pandemic Predominantly Hits Poor Neighborhoods, or does it? Evidence from Germany MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
France
- Epidemiological monitoring and control perspectives: application of a parsimonious modelling framework to the COVID-19 dynamics in France MedRxiv Server for Health Sciences: Coronavirus, May 24, 2020
- Monitoring and predicting SARS-CoV-2 epidemic in France after deconfinement using a multiscale age-stratified rate model MedRxiv Server for Health Sciences: Coronavirus, May 23, 2020
- French Open Organizers Working With Authorities to Avoid U.S. Open Clash New York Times: Coronavirus, May 23, 2020
- Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
- Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France MedRxiv Server for Health Sciences: Coronavirus, May 22, 2020
United Kingdom
- SARS-CoV-2 infection in London, England: Impact of lockdown on community point-prevalence, March-May 2020 MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- LONDON (AP) — Prime Minister Boris Johnson said Sunday he wouldn't fire his chief aide for allegedly violating the national lockdown rules that he helped to create by driving the length of England... AP Health News: Coronavirus, May 24, 2020
- New England: Film fest revs engines; Champlain fair canceled AP Health News: Coronavirus, May 23, 2020
Other International News
- ATHENS, Greece (AP) — Greece restarted regular ferry services to its islands Monday and cafes and restaurants were also back open for business as the country accelerated efforts to salvage its... AP Health News: Coronavirus, May 25, 2020
- Trump halts U.S. entry for foreigners who have recently been in Brazil Washington Post: Coronavirus, May 25, 2020
- SANTA FE, N.M. (AP) — Health officials have announced that New Mexico now has nearly 7,000 coronavirus cases as of Sunday. State Department of Health officials reported 149 additional... AP Health News: Coronavirus, May 24, 2020
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Business and Economic News
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Business News
- Good communication is critical to supporting people living and working with a rare disease: current rare disease support perceived as inadequate. MedRxiv Server for Health Sciences: Coronavirus, May 25, 2020
- Too Little Or Too Much Time With The Kids? Grandparenting Is Tough In A Pandemic NPR: Health, May 25, 2020
- WASHINGTON (AP) — Many laid-off workers who lost health insurance in the coronavirus shutdown soon face the first deadlines to qualify for fallback coverage under the Affordable Care... AP Health News: Coronavirus, May 25, 2020
Economics Blogs
- The role of global supply chains in the COVID-19 pandemic and beyond VoxEU.org, May 25, 2020
- Tracing The Origins Of COVID-19 Zero Hedge, May 24, 2020
- China Touts 1.5 Million Wuhan Residents Tested For COVID-19 In Single Day Zero Hedge, May 24, 2020
Top Economics News
- Coronavirus spreads throughout Latin America | Society - The Union Journal (Brazilian Economy), May 25, 2020
- Brexit and Covid-19 mean new car registrations continue to tumble - Consultancy.uk (Brexit Economy News), May 25, 2020
- 10 Medium To Longer-Term Implications From The Coronavirus Shock - ShareCafe (ECB Quantitative Easing), May 25, 2020
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Law Technology
- How Law Firms Are Responding to COVID-19 [Survey Results] LLRX.com, May 25, 2020
- Is the Spread of the COVID-19 Coronavirus Being Slowed? Data Science Central: Featured Blog Posts, May 24, 2020
- When COVID-19 is a joke: Stand-up comedy versus livestreaming’s limits Ars Technica, May 24, 2020
Legal Administrator
- TEST: Perspective: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, May 23, 2020
- Weekly SSRN Tax Article Review And Roundup: Layser Reviews Ryznar's Extending The Charitable Deduction Beyond The COVID-19 Pandemic TaxProf Blog, May 22, 2020
- Back to Brick-and-Mortar: Law Firms Reopen S-L-O-W-L-Y in the COVID-19 Era. Blog of Legal Times, May 22, 2020
- DOWNLOAD: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, May 22, 2020
- **COVID-19 Alert** U.S. Department of Justice ADA: News, May 22, 2020
- eDiscovery Before and After COVID-19: What to Expect American Bar Association: Law Technology Today, May 22, 2020
Librarian News
- How Law Firms Are Responding to COVID-19 [Survey Results] LLRX.com, May 25, 2020
- London Review Of Books: Linguistic Challenges, Covid & The Boris Government House of Butter, May 24, 2020
- LexBlog Article: IP and the Novel Coronavirus: Developing a Vaccine House of Butter, May 23, 2020
Leading Law Departments
- TEST: Perspective: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, May 23, 2020
- DOWNLOAD: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, May 22, 2020
- Agiloft Employees Step Up During COVID-19 Agiloft Blog, May 22, 2020
- Why This Lawyer Increased His Fees During the COVID-19 Pandemic General Counsel News, May 22, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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