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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
6,447,676 |
382,412 |
| US |
1,881,205 |
108,059 |
Will COVID-19 kill mass transit? Nothing screams unavoidable proximity quite like public transportation at rush hour. With governments around the country easing up on stay-at-home orders, Americans seem to be returning to their cars with enthusiasm. The future for mass transit may be less rosy..
Research News
9.0% of population in Milan Has Antibodies to SARS-CoV-2 A seroprevalence study of blood donations in Milan found antibody prevalence rose from 2.7% to 9.0% over the course of the outbreak. Given that the younger age group giving samples is more likely to be exposed, this is probably a high end estimate of asymptomatic infections.
No Secondary Transmission Identified in Early COVID-19 Case* A contact investigation for an early confirmed case in Seattle identified 50 contacts, including 11 who reported unprotected face to face interaction. Of the 37 who were tested, none were positive for the virus. Of 23 tested six weeks later, none had antibodies. These results suggest that there was no secondary transmission for this patient.
RNA Vaccine Protects Primates from COVID-19 A single dose of an RNA based virus conferred immunity to primates challenged with SARS-CoV-2 in a Seattle based study. This promising result provides a strong candidate for a human vaccine.
Elevated Cholesterol May Enhance SARS-COV-2 Entry into Cells Research by a Chinese team suggests that high serum cholesterol facilitates the entry of the virus into human cells. If true, this could provide a partial explanation for the higher rates of severe disease among older patients.
Plasmin Appears to Mediate Thrombotic Events in COVID-19 Based on patterns of proteins unregulated in response to SARS-CoV-2, investigators propose a thrombogenesis model based on elevated plasmin levels priming interaction between complement and platelet activating systems in the lung epithelia. If this is correct, it suggests therapeutic pathways for treatment of that element of the disease.
Heavily Cited New York Seroprevalence Study Released NYS state Department of Health released an antibody study conducted at grocery stores in mid-April that estimated 20% of New York City residents had asymptomatic infections. They make little mention of the potential problems with selection bias in choosing from shoppers to represent the population. The Milan sample, which would not have this problem since they chose blood donors, found a 9.0% prevalence of antibodies. In fact there is serious potential for selection bias as outlined in my blogpost written when these data were first released. It is disappointing to see that there is no serious consideration of this flaw in their manuscript. This study should be considered with caution.
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Papers are not peer reviewed unless marked. *Peer reviewed.
Covid19- Ahead of the Curve.
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Clinical Laboratory and Diagnostics
- Traces of SARS-CoV-2 RNA in the Blood of COVID-19 Patients MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Pushing beyond specifications: Evaluation of linearity and clinical performance of a fully automated SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- EasyCOV : LAMP based rapid detection of SARS-CoV-2 in saliva MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
Emergency Care and Triage
- An inflammatory cytokine signature helps predict COVID-19 severity and death MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- COVID-19 :Determinants of Hospitalization, ICU and Death among 20,293 reported cases in Portugal MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- A Risk Score to Predict Admission to Intensive Care Unit in Patients With COVID-19: The ABC-GOALS Score MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
Infection Control
- Prevalence and acceptance of glove wearing practice among general population when visiting high risk are during local COVID-19 outbreak . MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Assessing visible aerosol generation during vitrectomy in the era of Covid-19 MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Scalable In-hospital Decontamination of N95 Filtering Facepiece Respirator with a Peracetic Acid Room Disinfection System MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
- Modelling the thermal inactivation of viruses from the Coronaviridae family in suspensions or on surfaces with various relative humidities. MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
- Factors affecting healthcare workers' compliance with social and behavioural infection control measures during emerging infectious disease outbreaks: Rapid evidence review. MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
Clinical Case Management
- Modelling to Predict Hospital Bed Requirements for Covid-19 Patients in California MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
- Safety Stock: Predicting demand on the supply chain in Brazilian hospitals during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
Clinical Course and Outcomes
- Prognostic value of visual quantification of lesion severity at initial chest CT in confirmed Covid-19 infection: a retrospective analysis on 216 patients MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Investigation of subsequent and co-infections associated with SARS-CoV-2 (COVID-19) in hospitalized patients MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Duration of Viral Clearance in IDF Soldiers with Mild COVID-19 MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
Impact on Other Specialties
- Early Impact of COVID-19 on Individuals with Eating Disorders: A survey of ~1000 Individuals in the United States and the Netherlands MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
- Prevalence of Hospital PCR Confirmed Covid-19 Cases in Patients with Chronic Inflammatory and Autoimmune Rheumatic Diseases MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
- Study protocol for COvid-19 Vascular sERvice (COVER) study: The impact of the COVID-19 pandemic on the provision, practice and outcomes of vascular surgery MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
Reviews, Commentary, and Miscellaneous
- Assessing the quality, readability and reliability of online information on COVID-19: an infoveillance observational study MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Knowledge, attitude, and perceptions towards the 2019 Coronavirus Pandemic: A bi-national survey in Africa MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
- A call for governments to pause Twitter censorship: a cross-sectional study using Twitter data as social-spatial sensors of COVID-19/SARS-CoV-2 research diffusion MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
- Study of the Sudanese perceptions of COVID-19: Applying the Health Belief Model. MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
Mental Health
- Emotional distress and associated sociodemographic risk factors during the COVID-19 outbreak in Spain MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Dreaming during Covid-19 pandemic: Computational assessment of dreams reveals mental suffering and fear of contagion MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Worsening of pre-existing psychiatric conditions during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
- Loneliness during lockdown: trajectories and predictors during the COVID-19 pandemic in 35,712 adults in the UK MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
- Belief in Conspiracy Theory about COVID-19 Predicts Mental Health and Well-being -- A Study of Healthcare Staff in Ecuador MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
Drug Development
- Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Chloroquine, hydroxychloroquine, and COVID-19: systematic review and narrative synthesis of efficacy and safety MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Vitamin C for the treatment of COVID-19: A living systematic review protocol MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
Newly Registered Clinical Trials
- Phase 3 Study to Determine if RTB101 Reduces the Severity of COVID-19 in Older Adults Residing in Nursing Homes June 1, 2020
- Hyperbaric Oxygen Therapy in Non-ventilated COVID-19 Patients June 1, 2020
- Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients June 1, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Structural Analysis of COVID-19 Main Protease and its Interaction with the Inhibitor N3 ChemRxiv (Covid), June 1, 2020
- Molecules inhibit the enzyme activity of 3-chymotrypsin-like cysteine protease of SARS-CoV-2 virus: the experimental and theory studies bioRxiv: The Preprint Server for Biology (Covid), June 1, 2020
- Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes bioRxiv: The Preprint Server for Biology (Covid), May 31, 2020
Vaccine Development
- Determinants of COVID-19 vaccine acceptance in Saudi Arabia: a web-based national survey MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
- COVIDep: A web-based platform for real-time reporting of vaccine target recommendations for SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), May 30, 2020
- Determinants of intent to uptake Coronavirus vaccination among respondents in Saudi Arabia: a web-based national survey MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
Epidemiology
- Reproductive number of COVID-19: A systematic review and meta-analysis based on global level evidence MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Predicting social distancing index during COVID-19 outbreak through online search engines trends MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Future scenarios for the SARS-CoV-2 epidemic in Switzerland: an age-structured model MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
Modeling and Prediction
- Quantitative modeling and analysis show country-specific optimization of quarantine measures can potentially circumvent COVID19 infection spread post lockdown MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- A Novel Method for the Estimation of a Dynamic Effective Reproduction Number (Dynamic-R) in the CoViD-19 Outbreak MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Analyzing Covid-19 Data using SIRD Models MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
Public Health Intervention
- A control approach to the Covid-19 disease using a SEIHRD dynamical model MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- CoViD-19 in Italy: a mathematical model to analyze the epidemic containment strategy and the economic impacts MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Using real-world contact networks to quantify the effectiveness of digital contact tracing and isolation strategies for Covid-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
Surveillance and sero-epidemiology
- SARS-CoV-2 PCR and antibody testing for an entire rural community: methods and feasibility of high-throughput testing procedures MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Remarkable variability in SARS-CoV-2 antibodies across Brazilian regions: nationwide serological household survey in 27 states MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Validation and Performance Comparison of Three SARS-CoV-2 Antibody Assays bioRxiv: The Preprint Server for Biology (Covid), May 31, 2020
- A serological assay to detect SARS-CoV-2 antibodies in at-home collected finger-prick dried blood spots MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
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Coronavirus Research Resources
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China
- A survey of the psychological status of primary school students who were quarantined at home during the coronavirus disease 2019 epidemic in Hangzhou China MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- COVID-19 higher morbidity and mortality in Chinese regions with lower air quality MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Sex differences and Psychological Stress: Responses to the COVID-19 epidemic in China MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
Iran
- Mosques in Iran to Resume Daily Prayers, President Says New York Times: Coronavirus, May 30, 2020
South Korea
- SEOUL, South Korea (AP) — In a cramped office in eastern Seoul, Hwang Seungwon points a remote control toward a huge NASA-like overhead screen stretching across one of the walls. AP Health News: Coronavirus, May 31, 2020
- Asia Today: India reports 8,000 new cases; South Korea 27 AP Health News: Coronavirus, May 31, 2020
- South Korea closes schools again amid coronavirus spike, days after reopening Washington Post: Coronavirus, May 30, 2020
- Distinctive trajectories of COVID-19 epidemic by age and gender: a retrospective modeling of the epidemic in South Korea MedRxiv Server for Health Sciences: Coronavirus, May 29, 2020
- Hundreds of South Korea schools close again after reopening CNN.com - Health, May 29, 2020
Italy
- CoViD-19 in Italy: a mathematical model to analyze the epidemic containment strategy and the economic impacts MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- ACE2 variants underlie interindividual variability and susceptibility to COVID-19 in Italian population MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
- Italy Records 111 New Coronavirus Deaths, 416 New Cases New York Times: Coronavirus, May 30, 2020
- Coronavirus Carers Left 'in Limbo' as Italian Region Vetoes Budget Rise New York Times: Coronavirus, May 29, 2020
Spain
- Emotional distress and associated sociodemographic risk factors during the COVID-19 outbreak in Spain MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- SARS-CoV-2 SEROPREVALENCE AMONG ALL WORKERS IN A TEACHING HOSPITAL IN SPAIN: UNMASKING THE RISK. MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
- Belgian Prince Tests Positive for Coronavirus After Attending Gathering in Spain New York Times: Coronavirus, May 30, 2020
- PARIS (AP) — Europe's extensive social welfare net was showing signs of fraying under economic strain from the coronavirus, as protests erupted Friday for a second day in Spain against layoffs by... AP Health News: Coronavirus, May 29, 2020
- BOGOTA, Colombia (AP) — The passenger from Spain that Sonia Sanchez picked up at the airport in Colombia's capital in March did not seem well. AP Health News: Coronavirus, May 29, 2020
Germany
- $10 Billion Bailout for Germany's Lufthansa Passes Hurdle New York Times: Coronavirus, May 30, 2020
- Germany's Merkel Rejects Trump Invite to Attend G7 Summit in Washington: Politico New York Times: Coronavirus, May 29, 2020
- COPENHAGEN, Denmark (AP) — Danish Prime Minister Mette Frederiksen said Friday her country will reopen its borders next month - with strings attached - to residents of neighboring Germany, as well... AP Health News: Coronavirus, May 29, 2020
France
- Brazil Has Record New Coronavirus Cases, Surpasses France in Deaths New York Times: Coronavirus, May 30, 2020
- France Eases Some Pandemic Restrictions And Will Reopen Restaurants, Bars And Parks NPR: Health, May 29, 2020
- Virus count revised, new clusters emerge as France reopens AP Health News: Coronavirus, May 29, 2020
- PARIS (AP) — As France is easing most virus-related restrictions next week, the French government is confident its contact-tracing app will be effective in the process to contain the spread of the... AP Health News: Coronavirus, May 29, 2020
- The Latest on the effects of the coronavirus outbreak on sports around the world: ___ French car manufacturer Renault says it is staying in Formula One despite planning a large number... AP Health News: Coronavirus, May 29, 2020
- France's Tourism Industry Asks Itself: Can We Save Summer? New York Times: Coronavirus, May 29, 2020
United Kingdom
- A reductive analysis of a compartmental model for COVID-19: data assimilation and forecasting for the United Kingdom MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Time courses of COVID-19 infection and local variation in socioeconomic and health disparities in England MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
- Links between air pollution and COVID-19 in England MedRxiv Server for Health Sciences: Coronavirus, May 30, 2020
Other International News
- Future scenarios for the SARS-CoV-2 epidemic in Switzerland: an age-structured model MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- Investigating spatiotemporal patterns of the COVID-19 in Sao Paulo State, Brazil MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
- COVID-19 :Determinants of Hospitalization, ICU and Death among 20,293 reported cases in Portugal MedRxiv Server for Health Sciences: Coronavirus, May 31, 2020
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Business and Economic News
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Business News
- Artist Rachel Cabitt Is Trapped In a Quarantine Horror Film Wired.com, June 1, 2020
- Meet ACE2, the Enzyme at the Center of the Covid-19 Mystery Wired.com, June 1, 2020
- One Free Press Coalition Spotlights Journalists Under Attack - June 2020 Wired.com, June 1, 2020
Economics Blogs
- Cumberland Advisors Market Commentary – S&P 500 After COVID-19 Cumberland Advisors: Market Commentary, June 1, 2020
- Cumberland Advisors Market Commentary – COVID-19 Impacts & Philanthropic Opportunities: GGA Interview with Atlanta Fed President Raphael Bostic Cumberland Advisors: Market Commentary, June 1, 2020
- The EEA COVID-19 research registry initiative VoxEU.org, June 1, 2020
Top Economics News
- Karl W. Smith: It's no longer Trump's economy, it's covid-19's - West Central Tribune (Trump Economy), June 1, 2020
- Fauci says Trump no longer talks much to him or the rest of the coronavirus task force - Business Insider - Business Insider (Trump Economy), June 1, 2020
- Trump plainly prefers fighting his countrymen to fighting the coronavirus - Vox.com (Trump Economy), June 1, 2020
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Law Technology
- US Federal District Court case activity slows amid Covid-19 crisis, Lex Machina analysis finds Global Legal Post: Big Stories, June 1, 2020
- Injustice Is Worse Than COVID-19 Above the Law - Legal Technology, June 1, 2020
- Will Companies’ Insurance Coverage Withstand the Onslaught of COVID-19 Claims?: Cybersecurity Trends EDiscovery Today, June 1, 2020
Legal Administrator
- Coronavirus (COVID-19)—trends in secondary equity fundraisings Lexis Corporate Law Blog, June 1, 2020
- US Federal District Court case activity slows amid Covid-19 crisis, Lex Machina analysis finds Global Legal Post: Big Stories, June 1, 2020
- Law Firm Cash Flow and COVID-19: How Law Firms are Adjusting New York State Bar Association, June 1, 2020
Librarian News
- Injustice Is Worse Than COVID-19 Above the Law, June 1, 2020
- COVID-19 has been a boon for law firm knowledge management — How do you make it last? Legal Executive Institute: Blog, June 1, 2020
- Upcoming Webinar: Law Firm Predictions & How CMOs Can Adjust to the New Post Covid-19 World – Part II with Jeffrey Grossman Legal Marketing Blog, June 1, 2020
Leading Law Departments
- Post-Covid Legal Careers: More Choice And Less Practice Inhouse Blog, June 1, 2020
- COVID-19: Due Diligence Considerations for M&A Transactions General Counsel News, June 1, 2020
- COVID-19 has been a boon for law firm knowledge management — How do you make it last? Legal Executive Institute: Blog, June 1, 2020
- Three Principles for Explicit Work Intake Criteria, post-COVID-19 Catalyst Consulting, May 30, 2020
- Covid-19 Law Firm Swag CorporateCounsel.net Blog, May 29, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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