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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
6,704,010 |
393,233 |
| US |
1,924,051 |
110,173 |
Research News
Wide Genetic Diversity of SARS-CoV-2 Within a Host Undercuts Prevailing Notion of Single Genome Infections A study from Oxford examined viral genotypes in individual hosts and found more variability within hosts than between hosts. That diversity is transmitted between hosts, fundamentally changing our understanding of the transmission of SARS-CoV-2.
SARS-CoV-2 Infects and Kills Cardiac Cells In vitro and in vivo studies demonstrate that the virus infects cardiomyocytes, stops beating, and induces apoptosis. The direct infection of the heart muscle cells had not been previously demonstrated.
Extracellular Vesicles (EVs) from Lung Cells Can Infect Cardiac Cells A separate team from the US and China found that extracellular vesicles containing the SARS-CoV-2 genome could infect cardiomyoctes.
Seroprevalence of SARS-CoV-2 Antibodies in Blood Donors and patients at the University Hospital in Zurich Between December and May, samples from 8,591 patients and 5,388 blood donors were tested. In May, seropositivity peaked at 36/2773 (1.3%) among patients and 27/2524 (1.1%) among blood donors. This was a meticulously conducted study with no chance for self selection bias. Given that the patient cohort was more likely to be ill and the blood donor was more likely to be healthy than the general population, the agreement between the cohorts is compelling,
Seroprevalence of SARS-CoV-2 Antibodies in non-COVID-19 Pediatric Patients in Seattle Tests of 1,775 residual serum samples from 1,076 children who were patients at Seattle Children's hospital in March and April of 2020 found that IgG positive rates rose to a peak of 1.4% seropositivity. Note that 2 of the 10 seropositive children had been diagnosed with the disease. Because this did not require subjects to agree to participate, it is less prone to selection bias than other designs, although it does represent children who were ill and, as such, may overestimate prevalence.
Seroprevalence of SARS-CoV-2 Antibodies Among Healthcare Workers in China Out of 797 health care workers in Wuhan with no symptoms of COVID-19, 4.4% (35) tested positive for antibodies. All wore full personal protective equipment.
Seroprevalence of SARS-CoV-2 Antibodies Among Healthcare Workers at an Academic Hospital in New York City Out of 285 self referred health care workers (HCW's) at Mt Sinai Medical Center, 36% tested positive or weakly positive for IgG. Because these are self referred subjects, it is not a representative sample and should be interpreted with caution.
Seroprevalence of SARS-CoV-2 Antibodies in Household Members of Essential Workers In a sample of 232 participants, "enriched with health care workers, including 30 known COVID-19 cases"in Chicago, 36% of the 202 subjects without a prior COVID-19 diagnosis were seropositive for IgG and 21/30 (70%) of the household members of the known cases were seropositive. NOTE: It is not at all clear from this study how the participants were selected, and whether or not all household members were tested. This cannot be considered a representative sample without further data and should be interpreted with caution.
SARS-CoV-2 Detected in the Breath of COVID-19 patients In a Chinese study, samples from 30 subjects, the virus was found in 17% of exhaled breathe condensates. Investigators estimated that those patients were exhaling between 1,000 and 100,000 copies of viral RNA per minute. Note that the description of methods in this paper is unclear so it is difficult to evaluate quality.
SARS-CoV-2 Detected in the Breath of COVID-19 patients awaiting discharge Another Chinese study found that 2 of 10 patient awaiting discharge with negative throat swabs for three days had the virus in their exhaled breath condensate at a concentration of 10,000 viral RNA copies per cubic meter, equivalent to 1400 copies per minute.
SARS-CoV-2 Detected in the Air and on Surfaces in Patient Rooms Sampling in multiple clinical settings in London hospitals involved with the care of COVID-19 patients found viral RNA in 11% of surface samples and in 39% of air samples, where it was measured at concentrations ranging from 10 to 1,000 viral genome copies per cubic meter. None of the samples produced culturable viruses.
SARS-CoV-2 testing in the Air and on Surfaces in non-Healthcare settings visited or inhabited by COVID-19 cases Sampling in a Singapore of places visited or occupied by two known cases found only 2/428 positive samples, one from the bedside wall and one from the bed handle of the a room stayed in by one of the cases.
SARS-CoV-2 testing in the Quarantine Households German researchers tested households of 21 COVID-19 cases in quarantine. Viral RNA was found in 0/15 air samples, 10/66 wastewater samples, 4/119 object samples. None of the positive samples could be cultured.
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*Preprint **Not peer reviewed.
Covid19- Ahead of the Curve.
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Clinical Laboratory and Diagnostics
- Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Development and Evaluation of an AI System for COVID-19 Diagnosis MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Improved and Simplified Diagnosis of Covid-19 using TE Extraction from Dry Swabs bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
Emergency Care and Triage
- Estimated Sp02/Fio2 ratio to predict mortality in patients with suspected COVID-19 in the Emergency Department: a prospective cohort study MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Performance of suspected influenza case definition before and during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Machine learning in predicting respiratory failure in patients with COVID-19 pneumonia - challenges, strengths, and opportunities in a global health emergency MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Infection Control
- Synergistic effects of anionic surfactants on coronavirus (SARS-CoV-2) virucidal efficiency of sanitizing fluids to fight COVID-19 bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
- Applying Heat and Humidity using Stove Boiled Water for Decontamination of N95 Respirators in Low Resource Settings MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- The Effect of Ultraviolet C Radiation Against SARS-CoV-2 Inoculated N95 Respirators MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Ozone Treatment for Elimination of Bacteria and SARS-CoV-2 for Medical Environments bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
- Disinfection of N95 Respirators with Ozone MedRxiv Server for Health Sciences: Coronavirus, June 1, 2020
Clinical Case Management
- Development and Validation of a Survival Calculator for Hospitalized Patients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Renin-angiotensin-aldosterone system inhibitors and mortality in patients with hypertension hospitalized for COVID-19: a systematic review and meta-analysis MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Early CPAP reduced mortality in covid-19 patients. Audit results from Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust. MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- The Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR) and routine hematological parameters of COVID-19 Patient : A perspective of the Indian scenario from a frontline pilot study of 32 COVID-19 cases in a Tertiary Care Institute of North India MedRxiv Server for Health Sciences: Coronavirus, June 1, 2020
- Low levels of the prognostic biomarker suPAR are predictive of mild outcome in patients with symptoms of COVID-19 - a prospective cohort study MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Safety of Breastfeeding in Mothers with SARS-CoV-2 Infection MedRxiv Server for Health Sciences: Coronavirus, June 1, 2020
ICU Care
- The COVID-19 Critical Care Consortium observational study: Design and rationale of a prospective, international, multicenter, observational study MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Clinical Course and Outcomes
- Syncope at SARS-CoV-2 onset due to impaired baroreflex response MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Viral Dynamics Matter in COVID-19 Pneumonia: the success of early treatment with hydroxychloroquine and azithromycin in Lebanon. MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Clinical features of COVID-19 patients in Abdul Wahab Sjahranie Hospital, Samarinda, Indonesia MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Reviews, Commentary, and Miscellaneous
- The expediency of local modelling to aid national responses to SARS-CoV-2. MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Benefit-risk analysis of health benefits of routine childhood immunisation against the excess risk of SARS-CoV-2 infections during the Covid-19 pandemic in Africa MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- The knowledge and practice towards COVID-19 pandemic prevention among residents of Ethiopia. An online cross-sectional study. bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
- Public Knowledge and Practices regarding COVID-19: A cross-sectional survey from Pakistan MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- COVID-19: Why SOLIDARITY and DisCoVeRy trials may fail to bring informative and timely results MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Mental Health
- Trauma-spectrum symptoms among the Italian general population in the time of the COVID-19 outbreak. MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Sex differences and Psychological Stress: Responses to the COVID-19 epidemic in China MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- A survey of the psychological status of primary school students who were quarantined at home during the coronavirus disease 2019 epidemic in Hangzhou China MedRxiv Server for Health Sciences: Coronavirus, June 1, 2020
Drug Development
- Identification of promising drug candidates against Non-Structural Protein 15 (NSP15) from SARS-CoV-2: an in silico assisted drug-repurposing studies ChemRxiv (Covid), June 3, 2020
- A SYSTEMATIC ANALYSIS OF THE TIME COURSE TO DEVELOP TREATMENTS FOR COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Enantiomers of Chloroquine and Hydroxychloroquine Exhibit Different Activities Against SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
Newly Registered Clinical Trials
- Cholecalciferol to Improve the Outcomes of COVID-19 Patients June 2, 2020
- Covid-19: Possible Role of Neutrophil Extracellular Traps June 2, 2020
- COVID-19 Convalescent Plasma (CCP) Transfusion June 2, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- In Silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19 ChemRxiv (Covid), June 3, 2020
- coronapp: a Web Application to Annotate and Monitor SARS-CoV-2 Mutations bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
- Targeted Intracellular Degradation of SARS-CoV-2 RBD via Computationally-Optimized Peptide Fusions bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
Vaccine Development
- A Scalable Topical Vectored Vaccine Candidate Against SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
Epidemiology
- Global between-countries variance in SARS-CoV-2 mortality is driven by reported prevalence, age distribution, and case detection rate MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Correlation of the global spread of coronavirus disease-19 with atmospheric air temperature MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Risk factors associated with mortality of COVID-19 in 2692 counties of the United States MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Modeling and Prediction
- On the COVID-19 Pandemic in Indian State of Maharashtra: Forecasting & Effect of different parameters MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Understanding Spatial Heterogeneity of COVID-19 Pandemic Using Shape Analysis of Growth Rate Curves MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- A Simple, SIR-like but Individual-Based l-i AIR Model: Application in Comparison of COVID-19 in New York City and Wuhan MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Public Health Intervention
- Changes in Reproductive Rate of SARS-CoV-2 Due to Non-pharmaceutical Interventions in 1,417 U.S. Counties MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- How efficient are the lockdown measures taken for mitigating the Covid-19 epidemic? MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- The Risk of Lifting COVID-19 Confinement in Mexico MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Surveillance and sero-epidemiology
- In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 bioRxiv: The Preprint Server for Biology (Covid), June 2, 2020
- Environmental and social analysis as risk factors for the spread of the novel coronavirus (SARS-CoV-2) using remote sensing, GIS and analytical hierarchy process (AHP): Case of Peru MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Serological surveys in Reunion Island of the first hospitalized patients revealed that long-lived immunoglobulin G antibodies specific against SARS-CoV2 virus are rapidly vanishing in severe cases MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
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Coronavirus Research Resources
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China
- Age differences in clinical features and outcomes in patients with COVID-19, Jiangsu, China: a retrospective, multi-center cohort study MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Sex differences and Psychological Stress: Responses to the COVID-19 epidemic in China MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- A survey of the psychological status of primary school students who were quarantined at home during the coronavirus disease 2019 epidemic in Hangzhou China MedRxiv Server for Health Sciences: Coronavirus, June 1, 2020
South Korea
- Association between NSAIDs use and adverse clinical outcomes among adults hospitalised with COVID-19 in South Korea: A nationwide study MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Italy
- The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Trauma-spectrum symptoms among the Italian general population in the time of the COVID-19 outbreak. MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Spain
- The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Germany
- Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- Antibody profiling of COVID-19 patients in an urban low-incidence region in Northern Germany MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
France
- Population mobility reductions during COVID-19 epidemic in France under lockdown MedRxiv Server for Health Sciences: Coronavirus, June 1, 2020
United Kingdom
- Potential impact of Covid-19 response measures on invasive pneumococcal disease in England and Wales MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
Other International News
- Mexico and parts of Brazil reopen after lockdown -- despite surging coronavirus cases CNN.com - Health, June 2, 2020
- Covid-19 testing strategies and lockdowns: the European closed curves, analysed by ``skew-normal'' distributions, the forecasts for the UK, Sweden, and the USA, and the ongoing outbreak in Brazil. MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- The Risk of Lifting COVID-19 Confinement in Mexico MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
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Business and Economic News
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Business News
- Tear gas: Prepare for what to do if you're exposed CNN.com - Health, June 3, 2020
- How to talk to your children about protests and racism CNN.com - Health, June 3, 2020
- Is It Safe Yet To Get Your Physical Or A Dental Checkup? NPR: Health, June 3, 2020
Economics Blogs
- Coronavirus credit support: Don’t let liquidity lifelines become a golden noose VoxEU.org, June 3, 2020
- Greater risk of severe COVID-19 in non-White ethnicities is not explained by cardiometabolic, socioeconomic, or behavioural factors, or by 25(OH)-vitamin D status: study of 1,326 cases from the UK Biobank MedRxiv Server for Health Sciences: Coronavirus, June 2, 2020
- The Euro after COVID-19 and the "Three Germanies" Economonitor, June 2, 2020
Top Economics News
- Brazil Reports Record Covid-19 Deaths as Surge Continues - Bloomberg (Brazilian Economy), June 3, 2020
- What is next for Brazil in its coronavirus fight? - Al Jazeera English (Brazilian Economy), June 3, 2020
- Coronavirus: Australia set for first recession in three decades BBC: Economy, June 3, 2020
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Law Technology
- Closing and Reopening: COVID-19's Impact on Law Library Services - InfoToday.com (Law Library), June 2, 2020
- Universities Are Lawyering Up to Fight COVID-19 Closure Class Actions Blog of Legal Times, June 2, 2020
- TEST: Perspective: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, June 2, 2020
Legal Administrator
- JD Class of 2019, Strong Employment Out of the Gate - But Careers Could Be Blown Up by Coronavirus Fallout Law and More, June 3, 2020
- Universities Are Lawyering Up to Fight COVID-19 Closure Class Actions Blog of Legal Times, June 2, 2020
- TEST: Perspective: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, June 2, 2020
Librarian News
- Coronavirus Is Taking Its Toll on Big Law Firms House of Butter, June 3, 2020
- Senators propose COVID-19 contact-tracing privacy bill beSpacific, June 3, 2020
- Universities Are Lawyering Up to Fight COVID-19 Closure Class Actions law.com: Newswire, June 3, 2020
Leading Law Departments
- A Perfect Storm: COVID 19, Financial Services & Model Risk Mitratech: Press Releases, June 3, 2020
- TEST: Perspective: The IG Elephant in the Room — Protecting your team and your firm in the age of Covid-19 InOutsource, June 2, 2020
- Concerns as Companies Reopen Workplaces Amid COVID-19, Littler Survey Finds General Counsel News, June 2, 2020
- Going Concern: Sifting Through Covid-19 Uncertainties CorporateCounsel.net Blog, June 2, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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