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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
7,323,516 |
413,731 |
| US |
2,045,549 |
114,148 |
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Research News
Cremation Rates in Wuhan Suggest Ten-fold Underreporting of Pandemic Deaths Media reports suggest that crematoria in Wuhan expanded hours from 4 to 24 hours/day, even after operations were modified to cut time per cremation in half. In addition, 40 temporary crematoria were put into operation. Based on these data and the sale of urns, investigators estimate that there were 36,000 deaths during the pandemic, more than ten times the official COVID-19 death toll of 2,524.
A Rapid, Inexpensive SARS-CoV-2 Chinese investigators describe a new test for the virus using a nanozyme based chemiluminescence paper assay for the spike antigen. The test detected a pseudo virus at concentrations of 7.8 x 10^6 copies per ml. Analysis could be done with a smartphone app. This has the potential to provide a rapid, inexpensive screening tool that requires no special equipment.
Human Genetic Variation Does Not Seem to Affect COVID-19 Severity A study using data on the sequence from the ACE2 and TMPRSS2 data (SARS-COV-2 receptors) for 50 thousand subjects from the UK Biobank does not find significant differences between the 74 subjects with known infections and those not infected. These results suggest that, at least with regard to receptor affinity, there is no clear evidence of genetic differences in susceptibility to COVID-19.
Autopsy Data Tracks SARS-CoV-2 in the Brain A German study of data from 32 COVID-19 autopsies suggests that entry to the central nervous system (CNS) occurs by invasion of the olfactory epithelium and follows the track of the first cranial nerve to the brain. The analysis also suggests that this invasion may be associated with thromboembolic strokes.
SARS-CoV-2 is Capable of Infecting a Broad Rang of Mammals A computer modeling study of the affinity of the viral spike protein and the ACE2 receptor concluded that the virus could infect a broad range of mammalian hosts, particularly primates. These findings tend to support the notion that this is of animal origin undercut the notion that it was enhanced in the laboratory.
Only 60% of Respondents in UK Survey Would Use Contact Tracking Apps A survey of 48,000 UK National Health Service (NHS) users found resistance to using smartphone based contact tracing apps, particularly among those who believe they might be infected. This documents the clear challenge faced in promoting these apps and limits their use for contact tracing.
Counties With Higher Black Populations Had Elevated Risk of Death from COVID 19 Even after accounting for household crowding and lower income, mortality rates in US counties rises with increasing proportions of African Americans. This further documents sharp disparities in the nature of the pandemic in this population group.
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*Preprint **Not peer reviewed.
Covid19- Ahead of the Curve.
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Clinical Laboratory and Diagnostics
- Comparative study of four SARS-CoV-2 Nucleic Acid Amplification Test (NAAT) platforms demonstrates that ID NOW performance is impaired substantially by patient and specimen type. bioRxiv: The Preprint Server for Biology (Covid), June 6, 2020
- iSCAN: An RT-LAMP-coupled CRISPR-Cas12 module for rapid, sensitive detection of SARS-CoV-2 MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- Development and implementation of a customised rapid syndromic diagnostic test for severe pneumonia MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Emergency Care and Triage
- Identification of Immune complement function as a determinant of adverse SARS-CoV-2 infection outcome MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Augmented Curation of Unstructured Clinical Notes from a Massive EHR System Reveals Specific Phenotypic Signature of Impending COVID-19 Diagnosis MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- Predicting individual risk for COVID19 complications using EMR data MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Infection Control
- ENVIRONMENTAL SAFETY EVALUATION OF THE PROTECTION AND ISOLATION SYSTEM FOR PATIENTS WITH COVID-19. MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Effect of gamma sterilization on filtering efficiency of various respiratory face-masks MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- Decontamination of face masks and filtering facepiece respirators via ultraviolet germicidal irradiation, hydrogen peroxide vaporisation, and use of dry heat inactivates an infectious SARS-CoV-2 surrogate virus. MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- Extended use or re-use of single-use surgical masks and filtering facepiece respirators: A rapid evidence review MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- UV-C irradiation is highly effective in inactivating and inhibiting SARS-CoV-2 replication MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Avoiding COVID-19: Aerosol Guidelines MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Clinical Case Management
- A systematic review of convalescent plasma treatment for COVID19 MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- CLINICAL PROPERTIES AND DIAGNOSTIC METHODS OF COVID-19 INFECTION IN PREGNANCIES: META-ANALYSIS MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Evaluation of Knowledge, Practices, Attitude and Anxiety of Pakistans Nurses towards COVID-19 during the Current Outbreak in Pakistan MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid-19 MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- Ozone therapy for patients with SARS-COV-2 pneumonia: a single-center prospective cohort study MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
ICU Care
- Mechanical ventilation utilization in COVID-19: A systematic review and meta-analysis MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- Mechanical ventilation utilization in COVID-19: A systematic review and meta-analysis MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- Emergency calls are early indicators of ICU bed requirement during the COVID-19 epidemic MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Clinical Course and Outcomes
- Multicenter point-prevalence evaluation of the utilization and safety of drug therapies for COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Understanding the impact of the COVID-19 pandemic on well-being and virtual care for people living with dementia and care partners living in the community MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- Profiles of Social Distance Compliance: Psychological and Situational Predictors of Risky Behavior during COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
Impact on Other Specialties
- Impact of COVID-19 on clinical practice, income, health and lifestyle behavior of Brazilian urologists MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- Paediatric Dentistry and the coronavirus (COVID-19) response in the North East of England and North Cumbria MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Reviews, Commentary, and Miscellaneous
- Pollen Explains Flu-Like and COVID-19 Seasonality MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- COVID-19 and HIV co-infection: a living systematic evidence map of current research MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- COVID 19 healthcare facility demand forecasts for rural residents MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
Mental Health
- 'Drawing on Wisdom to Cope with Adversity:' A Systematic Review Protocol of Older Adults' Mental and Psychosocial Health During Acute Respiratory Disease Propagated-Type Epidemics and Pandemics (COVID-19, SARS-CoV, MERS, and Influenza). MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Is the psychological well-being of a population associated with COVID-19 related survival? MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- The psychological effects of COVID-19 on frontline healthcare workers and how they are coping: a web-based, cross-sectional study from Pakistan MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- Adverse effects of COVID-19 related lockdown on pain, physical activity and psychological wellbeing in people with chronic pain MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
Drug Development
- Tocilizumab is associated with reduction of the risk of ICU admission and mortality in patients with SARS-CoV-2 infection MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- Tocilizumab for patients with COVID-19 pneumonia. The TOCIVID-19 phase 2 trial MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- Simultaneous Inhibition of Entry and Replication of Novel Corona Virus by Grazoprevir: A Computational Drug Repurposing Study ChemRxiv (Covid), June 5, 2020
Newly Registered Clinical Trials
- Efficacy of Ivermectin as Add on Therapy in COVID19 Patients June 5, 2020
- RAS and Coagulopathy in COVID19 June 5, 2020
- Online Learning of Veterinary Anatomy During COVID-19 Pandemic June 5, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Sequence Analysis and Structure Prediction of SARS-CoV-2 Accessory Proteins 9b and ORF14: Evolutionary Analysis Indicates Close Relatedness to Bat Coronavirus ChemRxiv (Covid), June 8, 2020
- COVID-19: age, Interleukin-6, C-Reactive Protein and lymphocytes as key clues from a multicentre retrospective study in Spain MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- Suppressive myeloid cells are a hallmark of severe COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Vaccine Development
- Landscape and Selection of Vaccine Epitopes in SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), June 7, 2020
- A shred of evidence that BCG vaccine may protect against COVID-19: Comparing cohorts in Spain and Italy MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- In silico design and characterization of multiepitopes vaccine for SARS-CoV from its Spike proteins bioRxiv: The Preprint Server for Biology (Covid), June 6, 2020
- Association of Bacille Calmette-Guérin (BCG), Adult Pneumococcal and Adult Seasonal Influenza Vaccines with Covid-19 Adjusted Mortality Rates in Level 4 European countries MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Epidemiology
- Clinical and behavioural characteristics of self-isolating healthcare workers during the COVID-19 pandemic: a single-centre observational study MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Risk and protective factors of SARS-CoV-2 infection - Meta-regression of data from worldwide nations MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Links between air pollution and COVID-19 in England MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
Modeling and Prediction
- Interplay of global multi-scale human mobility, social distancing, government interventions, and COVID-19 dynamics MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Multiscale dynamics of COVID-19 and model-based recommendations for 105 countries MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- A modified SEIR meta-population transmission based Modeling and Forecasting of the COVID-19 pandemic in Pakistan MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
Public Health Intervention
- THE ERA OF CORONAVIRUS; KNOWLEDGE, ATTITUDE, PRACTICES, AND BARRIERS TO HAND HYGIENE AMONG MAKERERE UNIVERSITY STUDENTS AND KATANGA COMMUNITY RESIDENTS. MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- The impact of COVID-19 control measures on social contacts and transmission in Kenyan informal settlements MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
Surveillance and sero-epidemiology
- SARS-CoV-2 IgG Antibody Responses in New York City MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- First environmental surveillance for the presence of SARS-CoV-2 RNA in wastewater and river water in Japan MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Are antibodies tests accurate? Understanding predictive values and uncertainty of serology tests for the novel coronavirus. MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
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Coronavirus Research Resources
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China
- Cremation based estimates suggest significant under- and delayed reporting of COVID-19 epidemic data in Wuhan and China MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- China and Iran Tried to Hack the Biden and Trump Campaigns Wired.com, June 6, 2020
Iran
- China and Iran Tried to Hack the Biden and Trump Campaigns Wired.com, June 6, 2020
Italy
- A shred of evidence that BCG vaccine may protect against COVID-19: Comparing cohorts in Spain and Italy MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- A simplified model for the analysis of COVID-19 evolution during the lockdown period in Italy MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Spain
- A shred of evidence that BCG vaccine may protect against COVID-19: Comparing cohorts in Spain and Italy MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- COVID-19: age, Interleukin-6, C-Reactive Protein and lymphocytes as key clues from a multicentre retrospective study in Spain MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- Monitoring life expectancy levels during the COVID-19 pandemic: Example of the unequal impact in Spanish regions MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Germany
- Modelling daily infections with Covid-19 in Germany, France, and Sweden with a trend line based on day-to-day reproduction rates MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
France
- Diet and physical activity during the COVID-19 lockdown period (March-May 2020): results from the French NutriNet-Sante cohort study MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- Modelling daily infections with Covid-19 in Germany, France, and Sweden with a trend line based on day-to-day reproduction rates MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
United Kingdom
- TRACKing Excess Deaths (TRACKED): an interactive online tool to monitor excess deaths associated with COVID-19 pandemic in the United Kingdom MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Links between air pollution and COVID-19 in England MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- The impact of occupational risk from COVID on GP supply in England: A cross-sectional study MedRxiv Server for Health Sciences: Coronavirus, June 6, 2020
- The impact of school reopening on the spread of COVID-19 in England MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
- Paediatric Dentistry and the coronavirus (COVID-19) response in the North East of England and North Cumbria MedRxiv Server for Health Sciences: Coronavirus, June 5, 2020
Other International News
- Characteristics and risk factors for COVID-19 diagnosis and adverse outcomes in Mexico: an analysis of 89,756 laboratory-confirmed COVID-19 cases MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- Analysis and Estimation of Length of In-Hospital Stay Using Demographic Data of COVID-19 Recovered Patients in Singapore MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- First environmental surveillance for the presence of SARS-CoV-2 RNA in wastewater and river water in Japan MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
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Business and Economic News
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Business News
- The Office Elevator In COVID Times: Experts Weigh In On Safer Ups And Downs NPR: Health, June 8, 2020
- A COVID-19 Reopening Readiness Index: The Key to Opening up the Economy MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
- On the Spread of Coronavirus Infection. A Mechanistic Model to Rate Strategies for Disease Management MedRxiv Server for Health Sciences: Coronavirus, June 7, 2020
Economics Blogs
- Unconventional fiscal policy to exit the COVID-19 crisis VoxEU.org, June 8, 2020
- Socioeconomic determinants of Covid-19 infections and mortality VoxEU.org, June 8, 2020
- June 7 COVID-19 Test Results Calculated Risk, June 7, 2020
Top Economics News
- Coronavirus: New UK travel quarantine rules a stunt, says Ryanair boss BBC: Economy, June 8, 2020
- Coronavirus: Scottish business rebound 'lagging behind' BBC: Economy, June 8, 2020
- Coronavirus 'a devastating blow for world economy' BBC: Economy, June 8, 2020
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Law Technology
- How does COVID-19 impact cloud adoption? Help Net Security, June 8, 2020
- Lockdowns Knock Down the Spread of COVID-19, but Only to a Point (and only early on) Data Science Central: Featured Blog Posts, June 7, 2020
- Mortality and co-morbidity Investigation in Italy under Covid-19 Data Science Central: Featured Blog Posts, June 7, 2020
Legal Administrator
- ‘Burnt Out, Hopeless, Drained’—Mental Health Concerns Are Prevalent During COVID-19 EntertainHR, June 8, 2020
Librarian News
- Article: The Disruption Of The Legal Industry In The Aftermath Of the COVID-19 Crisis House of Butter, June 8, 2020
- The Top Doctor Who Aced the Coronavirus Test beSpacific, June 7, 2020
- Coronavirus Depletes the Keepers of Europe’s Memory beSpacific, June 7, 2020
Leading Law Departments
- Exculpatory Agreements: Mitigating COVID-19 Related Risks as the Economy Reopens General Counsel News, June 7, 2020
- Beyond Force Majeure: Key Contract Terms in the Time of Covid-19 Linksquares Blog, June 5, 2020
- How to Ensure Your Organization Emerges from COVID-19 More Resilient Datasite (Merrill Corporation): Press Releases, June 5, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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