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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
7,595,791 |
423,819 |
| US |
2,089,701 |
116,034 |
Research News
Twenty percent of grocery workers test positive for SARS-CoV-2 Harvard researchers tested workers at in a randomly selected grocery store for the virus. 21 of 104 workers tested positive. Those working with direct customer exposure had 4.7 times the odds of infection. These results indicate a need for far more thorough screening and testing of front line workers, particularly those with high rates of customer exposure.
Viral Load for SARS-CoV-2 similar across age groups A comparison of the concentration of the virus in 3,300 samples from positive tests found no significant difference across age categories. These results suggest that children are as likely as adults to spread COVID-19.
British study provides most detailed picture of time frame for antibody response to date With two months of follow up on 177 cases of COVID-19 from the first detection of SARS-coV-2, this study provides fine detail on the timing of the emergence of antibodies and their duration. Of note, the study showed that some cases required several weeks to develop antibodies and, at 60 days, 8% had no detectable antibodies.
A recently identified immune response may play a key role in lung damage An extracellular structure composed of strands of DNA and mixture of enzymes and other proteins is part of a normal immune response created by neutrophils, but, according to this paper, it may play a major role in lung damage in COVID-19.
Genome analysis suggests that SARS-CoV-2 spreads in waves Sequencing of viral genomes from Philadelphia suggest that there are sequences of major expansion of the genome. This would be consistent with super-spreading events playing a major role in the spread of COVID-19.
Heparin may inhibit entry of SARS-CoV-2 into human cells In addition to helping to limit coagulation, heparin may play a role in limiting the infection by impaired the ability of the virus to enter human cells. The authors suggest that intranasal administration early in the course of infection might be particularly helpful.
Trials of Convalescent Plasma show a decrease in severe symptoms A meta-analysis of plasma from recovered patients was well tolerated and reduced recovery times in younger patients, but did not confer an advantage to older patients.
Radiation of lungs shows dramatic effects on COVID-19 in preliminary trial Five elderly patients (median age 90) with severe disease received whole lung radiation. Within 24 hours, three were weaned from oxygen, 4 showed radiographic improvement of the lungs and mental acuity improved. If these effects are replicated in a larger trial this could be an important tool for halting the disease in severely ill patients.
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Unless otherwise noted, these pre-prints are not peer reviewed.
Covid19- Ahead of the Curve.
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Clinical Laboratory and Diagnostics
- Decreased plasma levels of the survival factor renalase are associated with worse outcomes in COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Benchmarking Deep Learning Models and Automated Model Design for COVID-19 Detection with Chest CT Scans MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
Emergency Care and Triage
- A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Who should we test for COVID-19? A triage model built from national symptom surveys MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
Infection Control
- How Social Media and 3D Printing Tackles the PPE Shortage during Covid - 19 Pandemic MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
- Rapid inactivation of SARS-CoV-2 with Deep-UV LED irradiation bioRxiv: The Preprint Server for Biology (Covid), June 8, 2020
- Is the Current N95 Respirator Filtration Efficiency Test Sufficient for Evaluating Protection Against Submicrometer Particles Containing SARS-CoV-2? MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Principles and Practice of SARS-CoV-2 Decontamination of N95 Masks with UV-C MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
Clinical Case Management
- Presenting features of COVID-19 in older people: relationships with frailty, inflammation and mortality MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- In-Ear SpO2: A Tool for Wearable, Unobtrusive Monitoring of Hypoxaemia in COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- SARS-CoV-2 in first trimester pregnancy - does it affect the fetus? MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Nano short peptide nutrition intervention on the prognosis of patients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
- Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
ICU Care
- Reduced ICU demand with early CPAP and proning in COVID-19 at Bradford: a single centre cohort MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Mechanical ventilation utilization in COVID-19: A systematic review and meta-analysis MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
Clinical Course and Outcomes
- Cognitive impairment is a common comorbidity in COVID-19 deceased patients. A hospital-based retrospective cohort study. MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Functional and cognitive outcomes after COVID-19 delirium MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Survival and predictors of deaths of patients hospitalized due to COVID-19 from a retrospective and multicenter cohort study in Brazil MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
Impact on Other Specialties
- Hospital practice in COVID-19 times: Perceptions of the midwifery interns in Peru MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Early Impact of COVID-19 on Individuals with Eating Disorders: A survey of ~1000 Individuals in the United States and the Netherlands MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
- A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
Reviews, Commentary, and Miscellaneous
- Understanding Economic and Health Factors Impacting the Spread of COVID-19 Disease MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Paradigms about the COVID-19 pandemic: knowledge, attitudes and practices from medical students MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- VirusDIP: Virus Data Integration Platform bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
Mental Health
- Worries and concerns among healthcare workers during the coronavirus 2019 pandemic: a web-based cross-sectional survey MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Predictors of Mental Health during the early Covid-19 Pandemic in the US: role of economic concerns, health worries and social distancing MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
- Intimate Partner Violence Victimization and Perpetration among U.S. Adults during COVID-19: A Brief Report MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
Drug Development
- Systematic benefit-risk assessment for the use of chloroquine or hydroxychloroquine as a treatment for COVID-19: Establishing a dynamic framework for rapid decision-making MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Structure Basis for Inhibition of SARS-CoV-2 by the Feline Drug GC376 bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
- Therapeutic effectiveness of interferon-alpha2b against COVID-19: the Cuban experience MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
Newly Registered Clinical Trials
- COVID 19 Serology in Pulmonologists June 9, 2020
- Impact of the Covid-19 Pandemic on Gastrointestinal and Liver Diseases June 9, 2020
- Prophylactic Ivermectin in COVID-19 Contacts June 9, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Molecular Docking Analysis Of Some Phytochemicals On Two SARS-CoV-2 Targets bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
- D936Y and Other Mutations in the Fusion Core of the SARS-Cov-2 Spike Protein Heptad Repeat 1 Undermine the Post-Fusion Assembly bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
- Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
Vaccine Development
- Structural Motifs, Disorder, and the Efficacy of Viral Vaccines bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
- Human H-ferritin presenting RBM of spike glycoprotein as potential vaccine of SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
- Application of In-Silico Reverse Vaccinology for Designing Multi-Epitope Vaccine Against Coronavirus ChemRxiv (Covid), June 9, 2020
Epidemiology
- Estimating weekly excess mortality at sub-national level in Italy during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Excess mortality in England and Wales during the first wave of the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Variation in SARS-CoV-2 free-living survival and environmental transmission can modulate the intensity of COVID-19 outbreaks MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
Modeling and Prediction
- The epidemic consequences of virulence and free-living survival relationships in models of emerging outbreaks bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
- Does susceptibility to novel coronavirus (COVID-19) infection differ by age?: Insights from mathematical modelling MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Temporal evolution of COVID-19 in the states of India using SIQR Model MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
Public Health Intervention
- Interplay of global multi-scale human mobility, social distancing, government interventions, and COVID-19 dynamics MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- A web survey to assess the use efficacy of personnel protective materials among allied health care workers during COVID-19 pandemic at North-East India MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Quantifying hospital flows and occupancy due to COVID-19 outbreak in France. Was French lockdown effective? MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
Surveillance and sero-epidemiology
- Monitoring Health Systems by Estimating Excess Mortality MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- A benchmark of online COVID-19 symptom checkers MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- LAMP-Seq: Population-Scale COVID-19 Diagnostics Using Combinatorial Barcoding bioRxiv: The Preprint Server for Biology (Covid), June 9, 2020
Other
- A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
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Coronavirus Research Resources
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China
- Correlation analysis of risk factors and GSI score of a medical team assisting Wuhan city during the epidemic of COVID-19 in China -A cohort study MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
Italy
- Estimating weekly excess mortality at sub-national level in Italy during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Closed form solution of the SIR model for the COVID-19 outbreak in Italy MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
- Dynamics of the SARS-CoV-2 epidemic in the earliest-affected areas in Italy: 1 Mass screening for SARS-CoV-2 serological positivity (SARS-2-SCREEN). MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
- Modelling the epidemiological trend and behavior of COVID-19 in Italy MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
France
- Quantifying hospital flows and occupancy due to COVID-19 outbreak in France. Was French lockdown effective? MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Predictive usefulness of PCR testing in different patterns of Covid-19 symptomatology - Analysis of a French cohort of 12,810 outpatients MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- The estimated impact of the COVID-19 epidemic in the general population of France MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
United Kingdom
- Excess mortality in England and Wales during the first wave of the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Evidence for ethnic inequalities in mortality related to COVID-19 infections: Findings from an ecological analysis of England and Wales MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- A reductive analysis of a compartmental model for COVID-19: data assimilation and forecasting for the United Kingdom MedRxiv Server for Health Sciences: Coronavirus, June 8, 2020
Other International News
- Unreported cases for Age Dependent COVID-19 Outbreak in Japan MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Who is at the highest risk from COVID-19 in India? Analysis of health, healthcare access, and socioeconomic indicators at the district level MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
- Non-COVID-19 Deaths After Social Distancing in Norway MedRxiv Server for Health Sciences: Coronavirus, June 9, 2020
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Business and Economic News
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Business News
- Vaccine Makers Hedge Bets On Which One Will Emerge As Effective And Safe NPR: Health, June 10, 2020
- From Rent Freezes To Liquor Buybacks: How States Are Helping People Cope NPR: Health, June 10, 2020
- How Tear Gas Affects The Body — And Why It's Dangerous During This Pandemic NPR: Health, June 10, 2020
Economics Blogs
- COVID-19: Narrative economics, public policy and mental health VoxEU.org, June 10, 2020
- Additional 1,100 Daily COVID-19 Deaths Predicted Depending On Size Of Floyd Protests Zero Hedge, June 9, 2020
- The Deadly Fox News-Trump SyndicateAs the coronavirus crisis... Robert Reich, June 9, 2020
- COVID-19, populism, and sustainable development VoxEU.org, June 9, 2020
- Assessing Covid-19 Trends in Wisconsin EconBrowser, June 9, 2020
- Public Health Officials Alarmed By Rebound In New COVID-19 Cases As Protests Continue Zero Hedge, June 8, 2020
Top Economics News
- Covid-19’s $9 Trillion Global Price Tag Is Just The Beginning - Forbes (Brazilian Economy), June 10, 2020
- Ireland and Belgium warn of hard Brexit risk to Covid recovery plans - The Irish Times (Brexit Economy News), June 10, 2020
- New Zealand Celebrates End of Coronavirus Restrictions - VOA News (Brazilian Economy), June 10, 2020
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Law Technology
- Covid-19 Impact on Global E-Discovery Market 2020: Industry Size, Share, Trends, SWOT Analysis by Top Vendors, Demand Outlook And Forecast Report To 2025 - Cole of Duty (eDiscovery), June 9, 2020
- Big Boom in E-Discovery Software Market- Final Report will cover the impact analysis of COVID-19 on this industry, 2020-2025 |FTI Consulting, HP, IBM, kCura, Nuix, Symantec, ABBYY, EMC, Exterro, MetricStream, CMO Software - 3rd Watch News (eDiscovery), June 9, 2020
- Global E-Discovery Market 2020- Impact of COVID-19, Future Growth Analysis and Challenges | Symantec, Hewlett-Packard, IBM Corporation, Kcura Corporation, Zylab - Galus Australis (eDiscovery), June 9, 2020
Legal Administrator
- What Your Company Can Do Today to Protect Against Government Scrutiny of COVID-19 Relief Funding Inside Counsel, June 9, 2020
- Jobseeker and Hiring Trends in the COVID Era EntertainHR, June 9, 2020
- Nine law firms back call for UK government to put sustainability at heart of Covid-19 recovery Global Legal Post: Big Stories, June 9, 2020
Librarian News
- Article: 5 Strategies Law Firms Should Consider in a Post-COVID-19 Office Environment House of Butter, June 10, 2020
- COVID-19, tech and the SQE — the top talking points from LegalEdCon 2020 House of Butter, June 10, 2020
- Wake Up Call: Surge in Covid Litigation Work in View, Survey Says House of Butter, June 10, 2020
Leading Law Departments
- What Your Company Can Do Today to Protect Against Government Scrutiny of COVID-19 Relief Funding Inside Counsel, June 9, 2020
- The Lives of Lawyers: Rethinking What Is “Essential” for Lawyers in the Age of Coronavirus Zero: News and Insights, June 8, 2020
- Amazon Faces Lawsuit from Workers For Neglecting Guidelines on Coronavirus General Counsel News, June 8, 2020
- Stormy Weather: Examining COVID-19’s Financial Impact on Lawyers Legal Executive Institute: Blog, June 8, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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