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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
8,102,188 |
118,121 |
| US |
2,181,838 |
118,267 |
Hydroxychloroquine and COVID19: Attack of the Treatment Zombie The story of hydroxychloroquine should provide an object lesson in why science takes time and why drug companies are required to jump through all the hoops they do. It is not just because the government loves red tape. Sometimes, red tape saves lives.
Research News
Hydroxycholoroquine Provides No Benefit in Animal Studies Studies in hamsters and macaque monkeys found no benefits from hydroxychloroquine for the treatment of SARS-CoV-2 infections. In a proper drug evaluation, these studies would have been conducted first and these results would have ended further discussion of this as a treatment in humans.
Spanish Researchers Document Superspreaders with Genomics An analysis of global data on genetic sequences of SARS-CoV-2 demonstrates multiple episodes of explosive spread of individual clones that suggest super spreading events. This supports growing evidence that these events play a major role in the spread of this disease.
Italian Researchers Provide Tool for Tracking SARS-CoV-2 Mutations A team from Milan has developed research tools that account for the intra-host variability in the genome when developing models and maps of viral spread. The tool is open source and the authors have created a website that allows users to observe the spread and mutation of the virus over time.
COVID-19 Patients Have Elevated Rates of Blood Clots in their Legs. Russian researchers performed ultrasound exams on the legs of 75 COVID-19 patients and found deep venous thrombosis (clots in the veins) of 20% of patients and impaired blood flow in 71%. The two groups (DVT v. no DVT) did not differ significantly with respect to common risk factors including diabetes, hypertension, and heart disease.
Model Suggests Daily Workplace Testing May be Necessary to Stem Disease Spread. In the absence of other control measures, reducing the reproduction number for COVID-19 below 1.0 will require that workplace testing be conducted every one to two days.
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Unless otherwise noted, these pre-prints are not peer reviewed.
Covid19- Ahead of the Curve.
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Clinical Laboratory and Diagnostics
- Chimeric synthetic reference standards enable cross-validation of positive and negative controls in SARS-CoV-2 molecular tests bioRxiv: The Preprint Server for Biology (Covid), June 14, 2020
- ROBOCOV: An affordable open-source robotic platform for COVID-19 testing by RT-qPCR bioRxiv: The Preprint Server for Biology (Covid), June 14, 2020
- Overhauling a faulty control in the CDC-recommended SARS-CoV-2 RT-PCR test bioRxiv: The Preprint Server for Biology (Covid), June 13, 2020
Infection Control
- Safety Stock: Predicting demand on the supply chain in Brazilian hospitals during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Healthcare Worker COVID-19 Cases in Ontario, Canada: A Cross-sectional Study MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Upper-room ultraviolet air disinfection might help to reduce COVID-19 transmission in buildings MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
ICU Care
- Mechanical ventilation utilization in COVID-19: A systematic review and meta-analysis MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Clinical Course and Outcomes
- Planning for the aftershocks: a model of post-acute care needs for hospitalized COVID-19 patients MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- ARB/ACEI use and severe COVID-19: a nationwide case-control study MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Impact on Other Specialties
- COVID-19 challenges to dentistry in the new pandemic epicenter: Brazil MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Reviews, Commentary, and Miscellaneous
- Machine Learning Maps Research Needs in COVID-19 Literature bioRxiv: The Preprint Server for Biology (Covid), June 13, 2020
- When is SARS-CoV-2 in your shopping list? MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Global research trend in the treatment of the new Coronavirus diseases (COVID-19) : bibliometric analysis. MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Mental Health
- Impact on mental health care and on mental health service users of the COVID-19 pandemic: a mixed methods survey of UK mental health care staff MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Burnout among healthcare professionals during COVID-19 pandemic: a cross-sectional study MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Dynamics of psychological responses to Covid-19 in India: A longitudinal study MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Factors linked to changes in mental health outcomes among Brazilians in quarantine due to COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Drug Development
- How Does Arbidol Inhibit the Novel Coronavirus SARS-CoV-2? Atomistic Insights from Molecular Dynamics Simulations ChemRxiv (Covid), June 15, 2020
- Analysis of Infected Host Gene Expression Reveals Repurposed Drug Candidates and Time-Dependent Host Response Dynamics for COVID-19 bioRxiv: The Preprint Server for Biology (Covid), June 14, 2020
- Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region bioRxiv: The Preprint Server for Biology (Covid), June 12, 2020
Newly Registered Clinical Trials
- Covid-19 at the Regional Medical Center Metz-Thionville: a Descriptive Study June 12, 2020
- Safety, Tolerability and Efficacy of Nangibotide in Mechanically Ventilated Patients With COVID-19 and Features of Systemic Inflammation June 12, 2020
- Health Professional Exposure Assessment to Covid-19 June 12, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- SARS-CoV-2 Spike Glycoprotein and ACE2 interaction reveals modulation of viral entry in different hosts bioRxiv: The Preprint Server for Biology (Covid), June 14, 2020
- Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon bioRxiv: The Preprint Server for Biology (Covid), June 14, 2020
- Colon Cancer and SARS-CoV-2: Impact of ACE2 Expression in Susceptibility to COVID-19 bioRxiv: The Preprint Server for Biology (Covid), June 14, 2020
Vaccine Development
- Multi-epitope Based Peptide Vaccine Design Using Three Structural Proteins (S, E, and M) of SARS-CoV-2: An In Silico Approach bioRxiv: The Preprint Server for Biology (Covid), June 14, 2020
- A Versatile Platform to Incorporate Viral Trimeric Antigens into Self-Assembling Nanoparticle Immunogens bioRxiv: The Preprint Server for Biology (Covid), June 13, 2020
- Hidden in plain sight: The effects of BCG vaccination in COVID-19 pandemic bioRxiv: The Preprint Server for Biology (Covid), June 13, 2020
Epidemiology
- Estimating Lower Bounds for COVID-19 Mortality from Northern Italian Towns MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- COVID-19 Deaths: Which Explanatory Variables Matter the Most? MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Transformed time series analysis of first-wave COVID-19: universal similarities found in the Group of Twenty (G20) Countries MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Modeling and Prediction
- COVID-19 Spread in India: Dynamics, Modeling, and Future Projections MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Nearly Perfect Forecasting of the Total COVID-19 Cases in India: A Numerical Approach MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- A Time-Dependent SEIRD Model for Forecasting the COVID-19 Transmission Dynamics MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- A Logistic Model for Age-Specific COVID-19 Case-Fatality Rates MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Public Health Intervention
- A targeted e-learning approach to reduce student mixing during a pandemic bioRxiv: The Preprint Server for Biology (Covid), June 12, 2020
- A Comprehensive Public Health Evaluation of Lockdown as a Non-pharmaceutical Intervention on COVID-19 Spread in India: National Trends Masking State Level Variations MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Estimating the Impact of Control Measures to Prevent Outbreaks of COVID-19 Associated with Air Travel into a COVID-19-free country: A Simulation Modelling Study MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Surveillance and sero-epidemiology
- Validation and performance of a quantitative IgG assay for the screening of SARS-CoV-2 antibodies bioRxiv: The Preprint Server for Biology (Covid), June 13, 2020
- Highly sensitive and specific multiplex antibody assays to quantify immunoglobulins M, A and G against SARS-CoV-2 antigens bioRxiv: The Preprint Server for Biology (Covid), June 13, 2020
- Sensitivity of commercial Anti-SARS-CoV-2 serological assays in a high-prevalence setting MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Evaluating COVID-19 screening strategies based on serological tests MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Sentinel surveillance of SARS-CoV-2 in wastewater anticipates the occurrence of COVID-19 cases MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Kinetics of the humoral immune response to SARS-CoV-2: comparative analytical performance of seven commercial serology tests MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
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Coronavirus Research Resources
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China
- Zoom Shut Down US-Based Activists at China's Request Wired.com, June 13, 2020
Italy
- Prosecutors Question Italy's Top Leaders Over Coronavirus Response NPR: Health, June 12, 2020
- Estimating Lower Bounds for COVID-19 Mortality from Northern Italian Towns MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- Analysis of the time evolution of SARS-CoV-2 lethality rate in Italy: Evidence of an unaltered virus potency MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Spain
- Modelling of the second (and subsequent) waves of the coronavirus epidemic. Spain and Germany as case studies MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
Germany
- Modelling of the second (and subsequent) waves of the coronavirus epidemic. Spain and Germany as case studies MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
France
- France Announces Further Reopening Amid Declining Number Of Coronavirus Cases NPR: Health, June 15, 2020
Other International News
- 100 Graves Dug At Copacabana Beach To Protest Brazil's COVID-19 Response NPR: Health, June 12, 2020
- A Comprehensive Public Health Evaluation of Lockdown as a Non-pharmaceutical Intervention on COVID-19 Spread in India: National Trends Masking State Level Variations MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
- COVID-19 challenges to dentistry in the new pandemic epicenter: Brazil MedRxiv Server for Health Sciences: Coronavirus, June 15, 2020
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Business and Economic News
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Business News
- Some states are seeing record coronavirus hospitalizations CNN.com - Health, June 15, 2020
- What Zebra Mussels Can Tell Us About Errors In Coronavirus Tests NPR: Health, June 15, 2020
- France Announces Further Reopening Amid Declining Number Of Coronavirus Cases NPR: Health, June 15, 2020
Economics Blogs
- South Carolina Reports 4th Straight Record Jump As COVID-19 Cases Surge Across The South: Live Updates Zero Hedge, June 14, 2020
- How Sweden’s Touted Approach to COVID-19 Is Working So Far The Daily Signal: Heritage.org, June 14, 2020
- How To Survive Corporate Idiocy in the Age of George Floyd (and Covid too) Economic Policy Journal, June 14, 2020
Top Economics News
- Brazil faces the coronavirus disaster almost everyone saw coming - The Washington Post (Brazilian Economy), June 15, 2020
- UK Faces Historic Dual Coronavirus, Brexit Challenges, Though Counterbalancing Economic Strengths Remain - FX Empire (Brexit Economy News), June 15, 2020
- The Week Ahead – Central Banks, Economic Data, COVID-19, and Brexit in Focus - Yahoo Finance (Brexit Economy News), June 15, 2020
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Law Technology
- Will COVID Change Lawyer Collaboration? Strategic Legal Technology - Ron Friedmann, June 14, 2020
- BBC: Coronavirus: The human cost of virus misinformation Stephen's Lighthouse, June 14, 2020
- UK Bobby Seagull: ‘Libraries have a central role to play in a post-Covid world’ Stephen's Lighthouse, June 13, 2020
Legal Administrator
- Will COVID Change Lawyer Collaboration? Prism Legal, June 14, 2020
- New York State Bar Association Remembers Lawyers Lost To COVID-19 New York State Bar Association, June 13, 2020
- Law.com Editors to Share a Sector-by-Sector Analysis of the Legal Industry Post-COVID Blog of Legal Times, June 12, 2020
Librarian News
- Will COVID Change Lawyer Collaboration? Strategic Legal Technology - Ron Friedmann, June 14, 2020
- New Florida Community Coronavirus Dashboard posted independent of state control beSpacific, June 14, 2020
- COVID-19: Remote Voting Trends and the Election Infrastructure Subsector beSpacific, June 14, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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