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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
8,400,129 |
451,263 |
| US |
2,234,471 |
119,941 |
What If There Is no Immunity? Two papers, released today as preprints, suggest we may need to consider a future in which we must learn to live with COVID-19.
Research News
Immunity to Other Strains of Coronavirus is Short-lived. A cohort study of ten otherwise healthy subjects found an average of 13.2 coronavirus infections over the course of 20.6 years average follow-up. Each infection involved one of 4 strains of coronavirus (not COVID-19). Individual subjects were infected as many as 12 times with the individual strains and reinfection with the same strain could occur in as little as 6 months. This raises serious concerns about the durability of immunity and the viability of a vaccine for COVID-19.
Mutations in SARS-CoV-2 Can Cause 3-fold Variation in Infectiousness A Japanese study found that different mutations in the spike protein of the virus can alter the ability of the virus to enter cells in culture by more than a factor of three suggesting that mutations may have a major impact on virulence.
Contact Tracing and Viral Genetics Suggest Low Doses of SARS-CoV-2 may be infectious. Investigators used the tools of viral genetics to analyze data from a contact tracing study of the first cases in Germany. By looking at the intrahost variants for the subgenomic fragments of RNA, the investigators identify infection by what originated as a minority sequence in the index case. In other words, the data indicate that a small fraction of the viruses present in the host may be responsible for the infection in the contact. From this, the authors conclude that a low dose viral exposure, perhaps from a fomites, could be responsible for several transmission episodes in this cluster.
SARS-CoV-2 in River Water in Ecuador Raises Possibility of Waterborne Spread Many studies have documented the virus in wastewater. This study from Quito finds the virus in river water and raises the possibility of waterborne spread of COVID-19 in low sanitation countries.
SARS-CoV-2 in Breastmilk Not Infectious A study of 18 women with COVID-19 found SARS-CoV-2 RNA in one sample of breastmilk, but the viral culture was negative. This suggests that breastmilk cannot transmit the virus.
Seroprevalence Studies in Wuhan Suggest Antibodies to SARS-CoV-2 many not be sustained. Seroprevalence studies from Wuhan found that 90% of COVID-19 patients and 4.0% of healthcare workers had antibodies to SARS-CoV-2. This suggests, particularly given the high rate of infections in healthcare workers, that antibody levels may not be sustained long term.
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Unless otherwise noted, these pre-prints are not peer reviewed.
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Clinical Laboratory and Diagnostics
- Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
- An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
- ROBOCOV: An affordable open-source robotic platform for SARS-CoV-2 testing by RT-qPCR bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
Emergency Care and Triage
- Symptom clusters in Covid19: A potential clinical prediction tool from the COVID Symptom study app MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Infection Control
- Development and validation of a tool to appraise guidelines on SARS-CoV-2 infection prevention strategies in healthcare workers MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Light propagation within N95 Filtered Face Respirators: A simulation study for UVC decontamination MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Clinical Case Management
- Hypokalemia in Patients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
ICU Care
- Development and validation of a knowledge-driven risk calculator for critical illness in COVID-19 patients MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Continuous positive airway pressure face-mask ventilation to manage massive influx of patients requiring respiratory support during the SARS-CoV-2 outbreak MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Clinical Course and Outcomes
- Association between NSAIDs use and adverse clinical outcomes among adults hospitalised with COVID-19 in South Korea: A nationwide study MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Concentration-dependent mortality of chloroquine in overdose MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Impact of Chronic Comorbidities on Progression and Prognosis in Patients with COVID-19: A Retrospective Cohort Study in 1031 Hospitalized Cases in Wuhan, China MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Impact on Other Specialties
- The Impact of COVID-19 Pandemic on Cardiology Services MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Risk and severity of COVID-19 and ABO blood group in transcatheter aortic valve patients MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Comparison of Mental Health Symptoms Prior to and During COVID-19 among Patients with Systemic Sclerosis from Four Countries: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort Study MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Reviews, Commentary, and Miscellaneous
- What Has Been the Impact of Covid-19 on Safety Culture? MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- COVID-19: a crash test for biomedical publishing? MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- What triggers online help-seeking retransmission during the COVID-19 period? Empirical evidence from Chinese social media MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Are health indicators able to describe the ability to cope of Health Systems with COVID-19 epidemic? MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Publish or perish: Reporting Characteristics of Peer-reviewed publications, pre-prints and registered studies on the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Mental Health
- Mental health service activity during COVID-19 lockdown: South London and Maudsley data on working age community and home treatment team services and mortality from February to mid-May 2020 MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Assessment of impact of COVID-19 outbreak & lockdown on mental health status & its associated risk and protective factors in adult Indian population MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- The inevitability of Covid-19 related distress among healthcare workers: findings from a low caseload country under lockdown MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Drug Development
- Drug Repurposing for Covid-19: Discovery of Potential Small-Molecule Inhibitors of Spike Protein-ACE2 Receptor Interaction Through Virtual Screening and Consensus Scoring ChemRxiv (Covid), June 17, 2020
- Genome-wide mapping of therapeutically-relevant SARS-CoV-2 RNA structures bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
- A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
- Compassionate Use of Tocilizumab in Severe SARS-CoV2 Pneumonia. When late administration is too late. MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- A systematic review protocol of the antiviral activity of chloroquine and hydroxychloroquine against COVID-19. MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Remdesivir Efficacy in Coronavirus Disease 2019 (COVID-19): A Systematic Review MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Mapping RNA dependent RNA polymerase activity and immune gene expression using PRO-seq bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
- The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
- Interfacial Water Molecules Make RBD of SPIKE Protein and Human ACE2 to Stick Together bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
Vaccine Development
- Multi-epitope Based Peptide Vaccine Design Using Three Structural Proteins (S, E, and M) of SARS-CoV-2: An bioRxiv: The Preprint Server for Biology (Covid), June 16, 2020
- Explore the Possible Impact of BCG Vaccination Policy on the Morbidity, Mortality, and Recovery Rates due to COVID-19 Infection. MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Epidemiology
- Understanding the Incidence of Covid-19 among the police force in Maharashtra through a mixed approach MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Risk of death by age and gender from CoVID-19 in Peru, March-May, 2020 MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Substitutions in Spike and Nucleocapsid proteins of SARS-CoV-2 circulating in South America MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Modeling and Prediction
- A model for COVID-19 transmission in Connecticut MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- COVID-19 IN INDIA: MODELLING, FORECASTING AND STATE-WISE COMPARISON MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Modelling the Occurrence of the Novel Pandemic COVID-19 Outbreak; A Box and Jenkins Approach MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Public Health Intervention
- Assessment of Early Mitigation Measures Against COVID-19 in Puerto Rico: March 15-May 15, 2020 MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Association of country-wide coronavirus mortality with demographics, testing, lockdowns, and public wearing of masks. Update June 15, 2020. MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Long time frames to detect the impact of changing COVID-19 control measures MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Simulation of Non-Pharmaceutical Interventions on COVID-19 with an Agent-based Model of Zonal Restraint MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Impact of social distancing measures for preventing coronavirus disease 2019 [COVID-19]: A systematic review and meta-analysis protocol MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Surveillance and sero-epidemiology
- Seroprevalence against COVID-19 and follow-up of suspected cases in primary health care in Spain MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Global and local mobility as a barometer for COVID-19 dynamics MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Cohen's kappa statistics as a convenient means to identify accurate SARS-CoV-2 rapid antibody tests MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Snapshot PCR Surveillance for SARS-CoV-2 in Hospital Staff in England MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
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Coronavirus Research Resources
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China
- Cremation based estimates suggest significant under- and delayed reporting of COVID-19 epidemic data in Wuhan and China MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Impact of Chronic Comorbidities on Progression and Prognosis in Patients with COVID-19: A Retrospective Cohort Study in 1031 Hospitalized Cases in Wuhan, China MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- Risk factors for critical-ill events of patients with COVID-19 in Wuhan, China: a retrospective cohort study MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- What triggers online help-seeking retransmission during the COVID-19 period? Empirical evidence from Chinese social media MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Iran
- High temperature has no impact on the reproduction number and new cases of COVID-19 in Bushehr, Iran MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
South Korea
- Association between NSAIDs use and adverse clinical outcomes among adults hospitalised with COVID-19 in South Korea: A nationwide study MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Spain
- Seroprevalence against COVID-19 and follow-up of suspected cases in primary health care in Spain MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Germany
- Low and high infection dose transmission of SARS-CoV-2 in the first COVID-19 clusters in Northern Germany MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
United Kingdom
- Snapshot PCR Surveillance for SARS-CoV-2 in Hospital Staff in England MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
Other International News
- Brazil Reports Big Surge In Coronavirus Infections NPR: Health, June 17, 2020
- Risk of death by age and gender from CoVID-19 in Peru, March-May, 2020 MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
- COVID-19 IN INDIA: MODELLING, FORECASTING AND STATE-WISE COMPARISON MedRxiv Server for Health Sciences: Coronavirus, June 16, 2020
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Business and Economic News
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Business News
- Cows Help With COVID-19 Treatment, No Bull NPR: Health, June 17, 2020
- The Rich Have Stopped Spending And That's Tanked The Economy NPR: Health, June 17, 2020
- Brazil Reports Big Surge In Coronavirus Infections NPR: Health, June 17, 2020
Economics Blogs
- The economic effects of COVID-19 containment measures VoxEU.org, June 17, 2020
- Decomposing demand and supply shocks during COVID-19 VoxEU.org, June 17, 2020
- COVID-19 fiscal stimulus measures and household spending in the US VoxEU.org, June 17, 2020
Top Economics News
- Coronavirus: NI faces 'deep and prolonged economic downturn’ - BBC News (Brexit Economy News), June 17, 2020
- Brexit Heartlands Pay the Highest Price for Coronavirus - BloombergQuint (Brexit Economy News), June 17, 2020
- Paying for coronavirus will have to be like war debt — spread over generations - Canadian Accountant (ECB Quantitative Easing), June 17, 2020
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Law Technology
- How the COVID-19 crisis is affecting UK small and medium-size enterprises McKinsey Insights & Publications, June 16, 2020
- Restarting after COVID-19: A Q&A with Clifford Chance’s David Metzger McKinsey Insights & Publications, June 16, 2020
- Navigating the post-COVID-19 era: A strategic framework for European recovery McKinsey Insights & Publications, June 16, 2020
- As COVID-19 cases increase, Pence blames prevalence of testing Ars Technica, June 16, 2020
- Mutation may be helping the coronavirus spread more readily Ars Technica, June 16, 2020
- COVID-19 death rate cut by cheap steroid, according to unpublished data Ars Technica, June 16, 2020
Legal Administrator
- Ryznar: Emergency Funds In The Wake Of The Coronavirus TaxProf Blog, June 17, 2020
Librarian News
- COVID-Lab: Mapping COVID-19 in Your Community beSpacific, June 17, 2020
- 4 Ways Coronavirus May Forever Change Legal Tech beSpacific, June 17, 2020
- McDonald’s Hit With New Suit Over Covid-19 Infections in Oakland Bloomberg Law, June 17, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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