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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
8,694,614 |
459,293 |
| US |
2,282,144 |
121,113 |
Research News
Lockdown Dramatically Reduced Symptoms of All Infectious Diseases An Israeli online survey study of daily symptoms likely to be associated with infectious disease was filled out over 2 million times since March 14. On March 19, a national state of emergency was declared and citizens were forbidden to leave their homes unless absolutely necessary. Over the next month coughing, rhinorrhea or nasal congestion, and the total number of symptoms declined by 74%, 70%, and 84% respectively. The total number of symptoms rebounded by 31% following reopening on May 13th. These data suggest that the lockdown dramatically reduced the spread of all infectious diseases, not just COVID-19.
Transmission of SARS-CoV-2 far higher in Latinx Communities During Lockdown in San Francisco Latinx ethnicity, inability to shelter in place, frontline service work, unemployment, and income below 50k all increased risk of infection during the lockdown. Among those with current infections (PCR positive) during this period, 96% were Latinx. These stark differences demonstrate profound inequities in the impact of the disease and in the effectiveness of public health prevention measures. Future measures must consider ways to improve public health protection for this community.
Study highlights critical importance of ventilation in prevention of COVID19 A detailed analysis of the super spreading event at a choir rehearsal in Washington state provides convincing evidence that the virus spread through aerosols. A combination of crowding, the nature and duration of the activity, and inadequate ventilation created the setting for a devastating outbreak. These results highlight the critical role mass indoor gatherings play in spreading the disease.
Anti-phospholipid antibodies may play key role in severe cases of COVID-19 A University of Michigan team found anti-phospholipid auto-antibodies in half of all COVID-19 patients. These are associated with the presence of neutrophil extracellular traps (NETS), which are in turn associated with severe lung pathology. One of these, calprotectin, is also associated with elevated platelets, D-dimers, and neutrophil count, as well as decreased lung and renal function. Introduction of COVID-19 IgG to mice dramatically increased thrombus formation. In sum, many of the antibodies created in response to SARS-CoV-2 play a key role in disease severity.
Patterns of mutation in SARS-CoV-2 suggest nature and direction of evolutionary pressure An analysis of viral genomes from around the world finds that the ORF1ab and S proteins are the most frequent sites of mutations. Weak to strong binding mutations (likely to cause more severe disease) appear to be more common than strong to weak. These mutations raise concerns about the potential for the virus to escape control from a single vaccine.
Saliva increases viability of viruses on surfaces Studies with a virus similar to SARS-CoV-2 finds that viruses transmitted in saliva droplets onto surfaces remain viable far longer than those transmitted in water. This increases the likelihood that fomites and transmit the virus.
Danish Researchers identify new potential anti-viral A polyether ionophore compound, X-206, inhibited the replication of the virus with more an impact on the virus that was more than 500 times its impact on human cells in culture. The authors suggest this category of chemicals may have potent anti-viral capacity.
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Unless otherwise noted, these pre-prints are not peer reviewed.
Recent Posts Covid19- Ahead of the Curve.
What if there's no immunity? Two papers, just released as preprints, suggest we may need to consider a future of coexistence with COVID-19.
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Clinical Laboratory and Diagnostics
- Utility of Lung Ultrasound in COVID-19: A Systematic Scoping Review MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Benchmarking Deep Learning Models and Automated Model Design for COVID-19 Detection with Chest CT Scans MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Artificial Intelligence for COVID-19 Risk Classification in Kidney Disease: Can Technology Unmask an Unseen Disease? MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Overhauling a faulty control in the CDC-recommended SARS-CoV-2 RT-PCR test panel bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
Emergency Care and Triage
- Delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Infection Control
- Virtual Assistant for COVID-19 PPE NIH: ClinicalTrials.gov, June 17, 2020
- Holder Pasteurization Inactivates SARS-CoV-2 in Human Breast Milk bioRxiv: The Preprint Server for Biology (Covid), June 18, 2020
- Safety Stock: Predicting demand on the supply chain in Brazilian hospitals during the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Genomic modeling as an approach to identify surrogates for use in experimental validation of SARS-CoV-2 and HuNoVs inactivation by UV-C treatment bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
- Catch and kill airborne SARS-CoV-2 to control spread of COVID-19 by a heated air disinfection system bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
Clinical Case Management
- COVID-19 in hemodialysis (HD) patients: Report from one HD center in Wuhan, China MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
ICU Care
- Assessment of the Effectiveness of Vibroacoustic Therapy for Respiratory Failure Caused by COVID 19 NIH: ClinicalTrials.gov, June 17, 2020
- Physical Rehabilitation in ICU in ARDS Patients With COVID-19 NIH: ClinicalTrials.gov, June 17, 2020
Clinical Course and Outcomes
- The male excess in case-fatality rates for COVID-19. A meta-analytic study of the age-related differences and consistency over six countries MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Impact on Other Specialties
- TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
Reviews, Commentary, and Miscellaneous
- Remote-by-Default Care in the COVID-19 Pandemic NIH: ClinicalTrials.gov, June 17, 2020
- Indian Publications on SARS-CoV-2: A Bibliometric Study of WHO COVID-19 Database MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Mental Health
- Risk of Depression in Family Caregivers: Unintended Consequence of COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Early impacts of the COVID-19 pandemic on mental health care and on people with mental health conditions: framework synthesis of international experiences and responses MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Drug Development
- In Silico Docking Studies of Antimalarial Drug Hydroxychloroquine to SARS-CoV Proteins :An Emerging Pandemic Worldwide ChemRxiv (Covid), June 18, 2020
- Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin bioRxiv: The Preprint Server for Biology (Covid), June 18, 2020
- Machine Learning Models Identify Inhibitors of SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
Newly Registered Clinical Trials
- Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen June 17, 2020
- Cardiovascular Implications of COVID-19 June 17, 2020
- Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19) June 17, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- in-silica Analysis of SARS-CoV-2 viral strain using Reverse Vaccinology Approach: A Case Study for USA bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
- AGE IS ASSOCIATED WITH INCREASED EXPRESSION OF PATTERN RECOGNITION RECEPTOR GENES AND ACE2, THE RECEPTOR FOR SARS-COV-2: IMPLICATIONS FOR THE EPIDEMIOLOGY OF COVID-19 DISEASE bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
Vaccine Development
- Towards intervention development to increase the uptake of COVID-19 vaccination among those at high risk: outlining evidence-based and theoretically informed future intervention content MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Epidemiology
- BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: preliminary findings from UK biobank MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- High temperature has no impact on the reproduction number and new cases of COVID-19 in Bushehr, Iran MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Impact of Daily Weather on COVID-19 outbreak in India MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Asymptomatic and presymptomatic transmission of SARS-CoV-2: A systematic review MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Causes of Death and Comorbidities in Patients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Genomic surveillance and phylogenetic analysis reveal multiple introductions of SARS-CoV-2 into a global travel hub in the Middle East bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
Modeling and Prediction
- Meso-scale modeling of COVID-19 spatio-temporal outbreak dynamics in Germany MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Estimating the Impact of Control Measures to Prevent Outbreaks of COVID-19 Associated with Air Travel into a COVID-19-free country: A Simulation Modelling Study MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Modeling COVID-19 dynamics in Illinois under non-pharmaceutical interventions MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Public Health Intervention
- Assessment of Early Mitigation Measures Against COVID-19 in Puerto Rico: March 15-May 15, 2020 MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- The Coronavirus Disease (COVID-19) Pandemic: Simulation-Based Assessment of Outbreak Responses and Post Peak Strategies MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- The effectiveness of social bubbles as part of a Covid-19 lockdown exit strategy, a modelling study MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Surveillance and sero-epidemiology
- High-Accuracy Multiplexed SARS-CoV-2 Antibody Assay with Avidity and Saliva Capability on a Nano-Plasmonic Platform bioRxiv: The Preprint Server for Biology (Covid), June 18, 2020
- Explainable machine learning models to understand determinants of COVID-19 mortality in the United States MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Diagnostic accuracy of six commercial SARS-CoV-2 IgG/total antibody assays and identification of SARS-CoV-2 neutralizing antibodies in convalescent sera MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- The effect of serological screening for SARS-CoV-2 antibodies to participants' attitudes and risk behaviour: a study on a tested population sample of industry workers in Split-Dalmatia County, Croatia MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Seroprevalence of Antibodies to SARS-CoV-2 in Healthcare Workers in Non-epidemic Region: A Report from Iwate Prefecture in Japan MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Array-based analysis of SARS-CoV-2, other coronaviruses, and influenza antibodies in convalescent COVID-19 patients bioRxiv: The Preprint Server for Biology (Covid), June 17, 2020
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Coronavirus Research Resources
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China
- COVID-19 in hemodialysis (HD) patients: Report from one HD center in Wuhan, China MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Iran
- High temperature has no impact on the reproduction number and new cases of COVID-19 in Bushehr, Iran MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Germany
- Meso-scale modeling of COVID-19 spatio-temporal outbreak dynamics in Germany MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
Other International News
- Impact of Daily Weather on COVID-19 outbreak in India MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
- Seroprevalence of Antibodies to SARS-CoV-2 in Healthcare Workers in Non-epidemic Region: A Report from Iwate Prefecture in Japan MedRxiv Server for Health Sciences: Coronavirus, June 17, 2020
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Business and Economic News
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Business News
- Bot Mafias Have Wreaked Havoc in 'World of Warcraft Classic' Wired.com, June 18, 2020
- 10 states are seeing their highest average of daily new Covid-19 cases since the pandemic started CNN.com - Health, June 18, 2020
- The FDA Revokes Its Emergency Use Authorization for Hydroxychloroquine Wired.com, June 17, 2020
Economics Blogs
- The role of social capital in the spread of Covid-19 VoxEU.org, June 18, 2020
- Compliance with social distancing during the Covid-19 crisis VoxEU.org, June 18, 2020
- Sweden’s constitution decides its exceptional Covid-19 policy VoxEU.org, June 18, 2020
- Responding to the Coronavirus Crisis and Building a Stronger Health Sector for the Future The Daily Signal: Heritage.org, June 18, 2020
Top Economics News
- What Investors Want to Know - Coronavirus Impact On Brazilian Local and Regional Governments - Fitch Ratings (Brazilian Economy), June 18, 2020
- Stock Markets Today: Virus, Covid-19, BOE, Brexit, Bolton, Trump - Bloomberg (Brexit Economy News), June 18, 2020
- For the U.K. and Ireland, Brexit and COVID-19 Are a Perfect Storm - World Politics Review (Brexit Economy News), June 18, 2020
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Law Technology
- The Future Ready Lawyer: Legal Innovation in the Age of COVID-19 ILTA Blogs, June 17, 2020
- WHO gives up on hydroxychloroquine for COVID-19, stops trials Ars Technica, June 17, 2020
- Coronavirus-Themed Cyberattacks Drop, Microsoft Threat Post, June 17, 2020
- MIT researchers say these are the unsafe businesses to avoid during COVID-19, and these are okay Stephen's Lighthouse, June 17, 2020
- Using Reverse Innovation to Fight Covid-19 Harvard Business Review, June 17, 2020
- Resilient or Stubborn? 5 Ways COVID-19 Hasn't Changed Legal Tech Law Technology News, June 17, 2020
Legal Administrator
- A report into enterprise software investment, amid the COVID-19 pandemic Docs Corp, June 18, 2020
- Daily Coronavirus Update: Economic Injury Disaster Loan Applications Reopened for Small Businesses and Non-Profits New York State Bar Association, June 17, 2020
- A Conversation to Help You Create Your Life in Harmony in a Post Covid-19 World Legal Marketing Blog, June 17, 2020
- Some Law Firms Are Losing Billing Cash Cows Due To COVID-19 Above the Law - Big Law, June 17, 2020
Librarian News
- Over half of legal workers stressed about job hunting amid coronavirus House of Butter, June 18, 2020
- Australia: Demand for legal service skyrockets in face of COVID-19 House of Butter, June 18, 2020
- Mckinseys: Restarting after COVID-19: A Q&A with Clifford Chance’s David Metzger House of Butter, June 18, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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