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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
8,981,252 |
468,051 |
| US |
2,342,597 |
122,067 |
Research News
Masks, hand washing, and social distancing estimated to SARS-CoV-2 infection risk by 84%. A study of 1,050 asymptomatic contacts of COVID-19 cases in Thailand compared those who tested positive for SARS-CoV-2 to those who did not. The adjusted odds ratios associated with protective measures were 0.23 for wearing a mask all the time, 0.15 for maintaining social distance >1 meter, 0.24 for keeping social contact <15 minutes, and 0.33 for frequent hand washing. All prevention measures combined were associated with a reduction in risk of 84%.
Italian blood donors 1.0% positive for SARS-COV-2 antibodies Over the course of the epidemic, Foggia, Italy has had a COVID-19 incidence rate of 0.19% for documented cases. In 904 samples of blood given during the month of May, 2 months after the pandemic, 9 or 0.99% tested positive. These cases are all required to be asymptomatic at the time of donation. The willingness to give blood is probably not correlated with a suspicion of having had or not had an infection, so selection bias seems unlikely, but blood donors might not represent the general population. They will tend to be younger (they must be less than 65) and healthier. They may also be more likely to be exposed to the virus than older people which would result in an over estimate of the true seroprevalence for the general population. These results suggest that asymptomatic cases represent 4-6 times the number of documented cases.
3.53% of Wuhan residents returning to work were seropositive for SARS-CoV-2 IgG Antibody testing was mandatory for those 18-65 returning to work, meaning this should provide an unbiased estimates of seroprevalence in this group. These results suggest the true infection rate is 3-4 times the reported number of cases.
Research adds to controversy over anti-phospholipid antibodies. A team of Italian researchers presents data countering the argument described in a previously featured paper that anti-phospholipid antibodies increase disease severity.
Impaired cellular immunity may play an important role in disease severity. A team from the Netherlands finds that severe cases of COVID-19 have similar IgG antibody response to less severe cases, but have marked differences in CD4+ T cell response.
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Unless otherwise noted, these pre-prints are not peer reviewed.
Recent Posts Covid19- Ahead of the Curve.
What If There Is No Immunity?
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Clinical Laboratory and Diagnostics
- SYBR green one-step qRT-PCR for the detection of SARS-CoV-2 RNA in saliva bioRxiv: The Preprint Server for Biology (Covid), June 19, 2020
- A new system in qualitative RT-PCR detecting SARS-CoV-2 in biological samples: an Italian experience. MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Investigation of Compatibility of SARS-CoV-2 RT-PCR Kits Containing Different Gene Targets During COVID-19 Pandemic MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
Infection Control
- Does Gender or Religion Contribute to the Risk of COVID-19 in Hospital Doctors? MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- UV-C Tower for point-of-care decontamination of filtering facepiece respirators MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- PERSONAL PROTECTIVE EQUIPMENT (PPE) USING IN ANTALYA 112 EMERGENCY AMBULANCE SERVICES DURING OUTBREAK MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Dry Heat as a Decontamination Method for N95 Respirator Reuse ChemRxiv (Covid), June 18, 2020
- Downsides of face masks and possible mitigation strategies: a systematic review and meta-analysis MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Introduction to and spread of COVID-19 in care homes in Norfolk, UK MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
Clinical Case Management
- Tracheostomy in a patient with COVID-19: a case report Oxford Academic Journals: Coronavirus, June 19, 2020
- Hypokalemia in Patients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
- Limited Role for Antibiotics in COVID-19: Scarce Evidence of Bacterial Coinfection MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
Clinical Course and Outcomes
- Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis of confounder-adjusted 20212 hospitalized patients MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- SEROPREVALENCE AND CLINICAL SPECTRUM OF SARS-CoV-2 INFECTION IN THE FIRST VERSUS THIRD TRIMESTER OF PREGNANCY MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Analysis of Genetic Host Response Risk Factors in Severe COVID-19 Patients MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
Impact on Other Specialties
- In-depth virological assessment of kidney transplant recipients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- The impact of the Covid-19 lockdown on the experiences and feeding practices of new mothers in the UK: Preliminary data from the COVID-19 New Mum Study MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients bioRxiv: The Preprint Server for Biology (Covid), June 19, 2020
Reviews, Commentary, and Miscellaneous
- The King's College London Coronavirus Health and Experiences of Colleagues at King's Study (KCL CHECK) protocol paper: a platform for study of the effects of coronavirus pandemic on staff and postgraduate students. MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Global Infodemiology of COVID-19: Focus on Google web searches and Instagram hashtags MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
- Rapid Utilization of Telehealth in a Comprehensive Cancer Center as a Response to COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
- Challenges of “Return to Work” in an Ongoing Pandemic New England Journal of Medicine: Coronavirus, June 18, 2020
- COVID-19-related coagulopathy – Is transferrin a missing link? bioRxiv: The Preprint Server for Biology (Covid), June 18, 2020
Mental Health
- Impact on mental health care and on mental health service users of the COVID-19 pandemic: a mixed methods survey of UK mental health care staff MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Mental Health Care for Military Personnel in the COVID-19 Epidemic Oxford Academic Journals: Coronavirus, June 19, 2020
- Did the General Population in Germany Drink More Alcohol during the COVID-19 Pandemic Lockdown? Oxford Academic Journals: Coronavirus, June 19, 2020
- Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
Drug Development
- Drug repurposing screens reveal FDA approved drugs active against SARS-Cov-2 bioRxiv: The Preprint Server for Biology (Covid), June 19, 2020
- Hydroxychloroquine and mortality risk of patients with COVID-19: a systematic review and meta-analysis of human comparative studies MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Statistical Issues and Lessons Learned from COVID-19 Clinical Trials with Lopinavir-Ritonavir and Remdesivir MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
Newly Registered Clinical Trials
- Daily Home Spirometry for Early Detection of Pulmonary Complications in Patients With COVID19 June 19, 2020
- Use of Convalescent Plasma for Treatment of Patients With COVID-19 Infection June 19, 2020
- Glucocorticoids in COVID-19 (CORTIVID) June 19, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- No evidence of coronaviruses or other potentially zoonotic viruses in Sunda pangolins (Manis javanica) entering the wildlife trade via Malaysia. bioRxiv: The Preprint Server for Biology (Covid), June 20, 2020
- Cytosine deamination in SARS-CoV-2 leads to progressive CpG depletion. bioRxiv: The Preprint Server for Biology (Covid), June 20, 2020
- Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution bioRxiv: The Preprint Server for Biology (Covid), June 20, 2020
Vaccine Development
- A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge bioRxiv: The Preprint Server for Biology (Covid), June 19, 2020
- Explore the Possible Impact of BCG Vaccination Policy on the Morbidity, Mortality, and Recovery Rates due to COVID-19 Infection. MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
Epidemiology
- Determinants of COVID-19 incidence and mortality: A cross-country analysis MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- High-density amplicon sequencing identifies community spread and ongoing evolution of SARS-CoV-2 in the Southern United States bioRxiv: The Preprint Server for Biology (Covid), June 19, 2020
- The Disproportionate Impact of COVID-19 on Racial and Ethnic Minorities in the United States Oxford Academic Journals: Coronavirus, June 20, 2020
Modeling and Prediction
- Essential epidemiological parameters of COVID-19 for clinical and mathematical modeling purposes: a rapid review and meta-analysis MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Trace, Quarantine, Test, Isolate and Treat: A Kerala Model of Covid-19 Response MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Multilevel Integrated Model with a Novel Systems Approach (MIMANSA) for Simulating the Spread of COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
Public Health Intervention
- On the Spread of Coronavirus Infection. A Mechanistic Model to Rate Strategies for Disease Management MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Assessing the effect of global travel and contact reductions to mitigate the COVID-19 pandemic and resurgence MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- A novel comprehensive metric to assess COVID-19 testing outcomes: Effects of geography, government, and policy response MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
Surveillance and sero-epidemiology
- Dog Savior: Immediate Scent-Detection of SARS-COV-2 by Trained Dogs bioRxiv: The Preprint Server for Biology (Covid), June 19, 2020
- Development of a SARS-CoV-2 total antibody assay and the dynamics of antibody response over time in hospitalized and non-hospitalized patients with COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Evaluation of the performance of SARS-CoV-2 serological tools and their positioning in COVID-19 diagnostic strategies. bioRxiv: The Preprint Server for Biology (Covid), June 19, 2020
Published Literature
- Considerations for Public Beaches CDC: Coronavirus Disease: What's New, June 18, 2020
- COVID-19 kills at home: the close relationship between the epidemic and the increase of out-of-hospital cardiac arrests Oxford Academic Journals: Coronavirus, June 20, 2020
- Evidence of SARS-CoV-2 mRNA in endomyocardial biopsies of patients with clinically suspected myocarditis tested negative for COVID-19 in nasopharyngeal swab Oxford Academic Journals: Coronavirus, June 20, 2020
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Coronavirus Research Resources
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China
- SARS-CoV-2 screening test for Japanese returnees from Wuhan, China, January 2020 Oxford Academic Journals: Coronavirus, June 20, 2020
- Seroprevalence and epidemiological characteristics of immunoglobulin M and G antibodies against SARS-CoV-2 in asymptomatic people in Wuhan, China MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Huang Hung: How Has China Used Collectivism To Navigate The Pandemic? NPR: Health, June 19, 2020
Iran
- Iran: WHO delivers laboratory supplies to Islamic Republic of Iran’s National Polio Laboratory WHO: Coronavirus disease (COVID-19) news, June 19, 2020
Italy
- A new system in qualitative RT-PCR detecting SARS-CoV-2 in biological samples: an Italian experience. MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- FAR AWAY FROM HERD IMMUNITY TO SARS-CoV-2: results from a survey in healthy blood donors in South Eastern Italy MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
Spain
- The extreme hotel hygiene awaiting tourists in Spain CNN.com - Health, June 19, 2020
Germany
- Higher risk of COVID-19 hospitalization for unemployed: an analysis of 1,298,416 health insured individuals in Germany MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Syndromic surveillance insights from a symptom assessment app before and during COVID-19 measures in Germany and the United Kingdom: results from repeated cross-sectional analyses MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Did the General Population in Germany Drink More Alcohol during the COVID-19 Pandemic Lockdown? Oxford Academic Journals: Coronavirus, June 19, 2020
France
- Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Compassionate use of hydroxychloroquine in clinical practice for patients with mild to severe Covid-19 in a French university hospital Infectious Diseases Society of America Journals: Coronavirus, June 18, 2020
- National French survey of COVID-19 symptoms in people aged 70 and over Infectious Diseases Society of America Journals: Coronavirus, June 18, 2020
United Kingdom
- Syndromic surveillance insights from a symptom assessment app before and during COVID-19 measures in Germany and the United Kingdom: results from repeated cross-sectional analyses MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Excess mortality in England and Wales during the first wave of the COVID-19 pandemic MedRxiv Server for Health Sciences: Coronavirus, June 18, 2020
Other International News
- Associations between wearing masks, washing hands, and social distancing practices, and risk of COVID-19 infection in public: a cohort-based case-control study in Thailand MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- Seroprevalence of Antibodies to SARS-CoV-2 in Healthcare Workers in Non-epidemic Region: A Hospital Report in Iwate Prefecture, Japan MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
- SARS-CoV-2 qRT-PCR Ct value distribution in Japan and possible utility of rapid antigen testing kit MedRxiv Server for Health Sciences: Coronavirus, June 19, 2020
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Business and Economic News
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Business News
- 20 Last-Minute Father's Day Gift Ideas and Deals (2020) Wired.com, June 20, 2020
- Ground-Penetrating Radar Mapped a Buried Ancient Roman City Wired.com, June 20, 2020
- We Need More Movies Where the Sharks Win Wired.com, June 20, 2020
Economics Blogs
- MiB: Jeremy Siegel on the Covid Stock Market The Big Picture, June 20, 2020
- COVID-19: A backward step for gender equality VoxEU.org, June 20, 2020
- The impact of COVID-19 on insurers VoxEU.org, June 20, 2020
Top Economics News
- Coronavirus: Brazil becomes second country to hit one million cases - BBC News (Carribean Economy), June 20, 2020
- How Is the U.S. Economy Handling COVID-19 So Far? - Morningstar.com (US Economy), June 20, 2020
- COVID-19 helps make huge impact on U.S. economy - Wahpeton Daily News (US Economy), June 20, 2020
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Law Technology
- People who believe COVID-19 conspiracies have these 7 tendencies Stephen's Lighthouse, June 20, 2020
- Coronavirus: an architect on how the pandemic could change our homes forever Stephen's Lighthouse, June 20, 2020
- How Technology Can Help Firms Prepare For a COVID-19 Future - Law.com (Legal Technology), June 19, 2020
Legal Administrator
- Weekly SSRN Tax Article Review And Roundup: Eyal-Cohen Reviews COVID-19 And The American Safety Net TaxProf Blog, June 19, 2020
- LTRC Live Zoom Roundtable Discussion: Working Remotely During COVID-19 American Bar Association: Law Technology Today, June 19, 2020
- More Post-Coronavirus (the 1st round, that is): Catching Up with David Lat, 44 Law and More, June 19, 2020
Librarian News
- Airlines Lawyer Up as Plaintiffs Seek MDL in Cases Demanding Refunds for COVID-19 Cancellations law.com: Newswire, June 20, 2020
- David Lat's COVID-19 Journey, Diversity Progress, Professionals Face Racism Too: What You Said law.com: Newswire, June 20, 2020
- Profiteering Off Publicly Funded COVID Treatments Above the Law, June 19, 2020
Leading Law Departments
- Citing COVID, Sutter Pushes to Revisit $575M Antitrust Settlement General Counsel News, June 19, 2020
- New contract risks in the time of COVID-19 Agiloft Blog, June 19, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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