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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
9,465,750 |
482,758 |
| US |
2,453,647 |
124,162 |
TRUMP SUPPORTERS ARE DYING FOR HIS REELECTION: THE EPIDEMIOLOGY OF DENIAL The science is clear. Those who attended the Tulsa rally (along with their friends and family wherever they came from) will be dying to see him re-elected. Literally. And Trump, through a perverse bioterrorism of ignorance and denial, is willing to let them die.
Research News
Genomic analysis identifies genes activated in severe cases An analysis of genes activated in patients hospitalized with COVID-19 as compared to sepsis patients finds 68 genes that are unique to SARS-CoV-2 response. These include a set associated with lipid programming, beta-catenin, and protein kinase C, all of which are involved in membrane repair, clotting, and wound healing. These suggest potential drug targets for further research.
Genetics of SARS-CoV-2 in Chicago suggest viral differences affect spread of the infection Three major clades of the virus were identified by researchers at Northwestern, one from New York, one from Seattle, and one emerging locally, were associated with different viral loads in the upper airways. The New York related clade was present in higher concentrations suggesting it would spread more easily.
SARS-CoV2 amplifies gene expression associated with aging. Genes that are altered in the elderly and are known to be involved in pro-inflammatory, apoptotic, T cell polarization pathways were up- regulated and those involved in viral replication suppression or the first barrier to viral infection remained downregulated in the elderly. These same genes are associated with poor prognosis for COVID-19. The pronounced overlap between aging and the response to the virus observed in the blood of the elderly may explain clinical symptoms more common in older age groups including blood clots, strokes, heart attack, multi-organ failure etc. in severe cases.
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Unless otherwise noted, these pre-prints are not peer reviewed.
Recent Posts Covid19- Ahead of the Curve.
HEADER TRAILER.
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Clinical Laboratory and Diagnostics
- THE USE OF DENATURING SOLUTION AS COLLECTION AND TRANSPORT MEDIA TO IMPROVE SARS-COV-2 RNA DETECTION AND REDUCE INFECTION OF LABORATORY PERSONNEL MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- A Combined Deep CNN-LSTM Network for the Detection of Novel Coronavirus (COVID-19) Using X-ray Images MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- SARS-CoV-2 RT-PCR profile in 298 Indian COVID-19 patients : a retrospective observational study MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Emergency Care and Triage
- Hospital-based autonomous pre-clinical screening of COVID-19: An emergency triage using a vital signs recording system, Paris-Ile de France region. MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Kidney function on admission predicts in-hospital mortality in COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Evaluating a Widely Implemented Proprietary Deterioration Index Model Among Hospitalized COVID-19 Patients MedRxiv Server for Health Sciences: Coronavirus, June 20, 2020
Infection Control
- SARS-CoV-2 in human milk is inactivated by Holder pasteurization but not cold storage MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Rapid Inactivation of SARS-CoV-2 by Silicon Nitride, Copper, and Aluminum Nitride bioRxiv: The Preprint Server for Biology (Covid), June 21, 2020
- Light propagation within N95 Filtered Face Respirators: A simulation study for UVC decontamination MedRxiv Server for Health Sciences: Coronavirus, June 20, 2020
- Ability of Fabric Facemasks Materials to Filter Ultrafine Particles at Coughing Velocity - for Home Made and Fabric Face Mask Creation MedRxiv Server for Health Sciences: Coronavirus, June 20, 2020
Clinical Case Management
- Clinical practice guidelines and recommendations in the context of the COVID-19 pandemic: systematic review and critical appraisal MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Clozapine treatment and risk of COVID-19. MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
ICU Care
- IL-13 Predicts the Need for Mechanical Ventilation in COVID-19 Patients MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Critical care demand and intensive care supply for patients in Japan with COVID-19 at the time of the state of emergency declaration in April 2020: a descriptive analysis. MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Clinical Course and Outcomes
- Lung disease severity, Coronary Artery Calcium, Coronary inflammation and Mortality in Coronavirus Disease 2019. MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- PROGNOSTIC FACTORS IN SPANISH COVID-19 PATIENTS: A CASE SERIES FROM BARCELONA MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Epidemiological Risk Factors Associated with Death and Severe Disease in Patients Suffering From COVID-19: A Comprehensive Systematic Review and Meta-analysis MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Impact on Other Specialties
- Clinical Outcomes of Patients with COVID-19 and Chronic Inflammatory and Autoimmune Rheumatic Diseases: A Multicentric Matched-Cohort Study MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- COVID-19 and first trimester spontaneous abortion: a case-control study of 225 pregnant patients MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Reviews, Commentary, and Miscellaneous
- Covid-19 Pandemic- Pits and falls of major states of India. MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Modeling quantitative traits for COVID-19 case reports MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Half of children entitled to free school meals do not have access to the scheme during the COVID-19 lockdown in the UK. MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Mental Health
- The immediate psychological response of the general population in Saudi Arabia during COVID-19 pandemic: a cross-sectional study MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Distress among Brazilian university students due to the Covid-19 pandemic: survey results and reflections MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- COVID-19 pandemic and health worker stress: The mediating effect of emotional regulation MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- COVID-19 preventive behaviors among people with anxiety and depression: Findings from Japan MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Dimensions and modulators of behavioural and mental-health changes during the Covid-19 pandemic: an N=343,017 study MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Drug Development
- anti-IL-6 versus anti-IL-6R Blocking Antibodies to Treat Acute Ebola Infection in BALB/c Mice with Potential Implications for Treating Patients Presenting with COVID-19 bioRxiv: The Preprint Server for Biology (Covid), June 21, 2020
- Inhaled corticosteroid use and risk COVID-19 related death among 966,461 patients with COPD or asthma: an OpenSAFELY analysis MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Chloroquine, but not hydroxychlorquine, prolongs the QT interval in a primary care population MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Characterizing transcriptional regulatory sequences in coronaviruses and their role in recombination bioRxiv: The Preprint Server for Biology (Covid), June 22, 2020
- SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts bioRxiv: The Preprint Server for Biology (Covid), June 21, 2020
- Analysis of SARS-CoV-2 specific T-cell receptors in ImmuneCode reveals cross-reactivity to immunodominant Influenza M1 epitope bioRxiv: The Preprint Server for Biology (Covid), June 21, 2020
Vaccine Development
- Engineered human mesenchymal stem cells as new vaccine platform for COVID-19 bioRxiv: The Preprint Server for Biology (Covid), June 21, 2020
Epidemiology
- The Covid-19 epidemic in the UK MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Practical considerations for measuring the effective reproductive number, Rt MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Racial and ethnic determinants of Covid-19 risk MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Modeling and Prediction
- Explainable machine learning models to understand determinants of COVID-19 mortality in the United States MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Simulation of COVID-19 Incubation Period and the Effect of Probability Distribution Function on Model Training Using MIMANSA MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Bayesian nowcasting with adjustment for delayed and incomplete reporting to estimate COVID-19 infections in the United States MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Modelling for prediction of the spread and severity of COVID-19 and its association with socioeconomic factors and virus types MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Investigation of the effect of temperature on the structure of SARS-Cov-2 Spike Protein by Molecular Dynamics Simulations bioRxiv: The Preprint Server for Biology (Covid), June 20, 2020
- Modeling COVID19 mortality in the US: Community context and mobility matter MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Public Health Intervention
- Critical levels of mask efficiency and of mask adoption that theoretically extinguish respiratory virus epidemics MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Predictable county-level estimates of R0 for COVID-19 needed for public health planning in the USA MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- LOCKDOWN AS A PANDEMIC MITIGATING POLICY INTERVENTION IN INDIA MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- The impact of lockdown measures on COVID-19: a worldwide comparison MedRxiv Server for Health Sciences: Coronavirus, June 20, 2020
- Analysis of Effectiveness of Quarantine Measures in Controlling COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 20, 2020
- Are we #stayinghome to Flatten the Curve? MedRxiv Server for Health Sciences: Coronavirus, June 20, 2020
Surveillance and sero-epidemiology
- SARS-CoV-2-specific antibody detection for sero-epidemiology: a multiplex analysis approach accounting for accurate seroprevalence MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Evaluation of the performance of SARS-CoV-2 serological tools and their positioning in COVID-19 diagnostic strategies bioRxiv: The Preprint Server for Biology (Covid), June 21, 2020
- Sewage surveillance for the presence of SARS-CoV-2 genome as a useful wastewater based epidemiology (WBE) tracking tool in India MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Published Literature
- WHO Director-General's opening remarks at the media briefing on COVID-19 - 19 June 2020 WHO: Coronavirus disease (COVID-19) news, June 22, 2020
- Entomology in the Time of COVID-19 Oxford Academic Journals: Coronavirus, June 22, 2020
- Establishing prison-led contact tracing to prevent outbreaks of COVID-19 in prisons in Ireland Oxford Academic Journals: Coronavirus, June 22, 2020
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Coronavirus Research Resources
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China
- Serum Cytokine and Chemokine profile in Relation to the Severity of Coronavirus disease 2019 (COVID-19) in China Infectious Diseases Society of America Journals: Coronavirus, June 20, 2020
- Spread dynamics of SARS-CoV-2 epidemic in China: a phylogenetic analysis MedRxiv Server for Health Sciences: Coronavirus, June 20, 2020
Italy
- News from the front: Estimation of excess mortality and life expectancy in the major epicenters of the COVID-19 pandemic in Italy MedRxiv Server for Health Sciences: Coronavirus, June 20, 2020
Spain
- PROGNOSTIC FACTORS IN SPANISH COVID-19 PATIENTS: A CASE SERIES FROM BARCELONA MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
France
- Hospital-based autonomous pre-clinical screening of COVID-19: An emergency triage using a vital signs recording system, Paris-Ile de France region. MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- Estimating the proportion of coronavirus disease 2019 (COVID-19) cases among households in France : a cross-sectional study on individuals with myocardial infarction history MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
Other International News
- Establishing prison-led contact tracing to prevent outbreaks of COVID-19 in prisons in Ireland Oxford Academic Journals: Coronavirus, June 22, 2020
- Covid-19 Pandemic- Pits and falls of major states of India. MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
- COVID-19 preventive behaviors among people with anxiety and depression: Findings from Japan MedRxiv Server for Health Sciences: Coronavirus, June 21, 2020
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Government
- WHO Director-General's opening remarks at the media briefing on COVID-19 - 19 June 2020 WHO: Coronavirus disease (COVID-19) news, June 22, 2020
- Speranza a Cts: serve approfondimento su nuove linee guida Oms su guarigioni Italian Ministry of Health: Coronavirus, June 21, 2020
- El Departamento de Salud comunica nuevos datos del COVID-19 ligados a la ocupación y la industria Washington State Department of Health: Coronavirus, June 20, 2020
- An Approach for Monitoring and Evaluating Community Mitigation Strategies for COVID-19 CDC: Coronavirus Disease: What's New, June 20, 2020
- Monitoring and Evaluation Logic Model CDC: Coronavirus Disease: What's New, June 20, 2020
- Community Mitigation CDC: Coronavirus Disease: What's New, June 20, 2020
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Business and Economic News
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Business News
- Entomology in the Time of COVID-19 Oxford Academic Journals: Coronavirus, June 22, 2020
- Nursing Homes Are Reopening In West Virginia, But Not Everyone Can Visit Yet NPR: Health, June 22, 2020
- Remembering Front-Line Workers Lost To COVID-19 NPR: Health, June 22, 2020
Economics Blogs
- COVID-19: Putting the Chinese policy reaction into context VoxEU.org, June 22, 2020
- Unmasked! The effect of face masks on the spread of COVID-19 VoxEU.org, June 22, 2020
- COVID-19, mental health, and domestic violence VoxEU.org, June 22, 2020
Top Economics News
- Look To Clement Attlee, And Not Churchill, For Britain's Post-Coronavirus Future - The National Interest (Brexit Economy News), June 22, 2020
- Live updates: More than two dozen states report coronavirus surges as Trump administration prepares for possible second wave - The Washington Post (Trump Economy), June 22, 2020
- Brazil and the U.S. Drive New Coronavirus Infections - The New York Times (Trump Economy), June 22, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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