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COVID-19 Report
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 The Count
| Region |
Cases |
Deaths |
| World |
10,331,979 |
506,088 |
| US |
2,653,440 |
128,567 |
Research News
SARS-CoV-2 detected in Italian wastewater last December Analysis of samples collected and stored as part of an ongoing study of wastewater in Italy found viral RNA in Milan and Turin on December 18. The limits of sensitivity for wastewater testing suggest that infections had been actively spreading since early December, at least 2 months before the first case of COVID 19 was diagnosed.
Seroprevalence studies in six states find SARS-CoV-2 infection rates 6-24 times reported number of cases Analyses of 11,933 residual clinical specimens between late March in April found antibodies in 1.1% (WA) to 6.9% (NYC) of tests. The use of residual clinical specimens eliminates the potential for self-selection bias present in studies using volunteers (see blog post below). On the other hand, it is conceivable that some of the samples came from patients being seen for conditions not thought to be related to COVID-19 that are actually due to SARS-CoV-2, making these overestimates of seroprevalence. Other studies of blood bank samples show good concurrence with residual clinical samples, making that error less likely. The ratios of estimated infections (based on seroprevalence) to reported cases were 11.2 (Puget Sound), 11.9 (New York City), 11.2 (South Florida), 23.8 (Missouri), 10.5 (Utah), and 6.0 (Connecticut). These results indicate that the actual number of infections is roughly 10 times the number of reported cases, suggesting the disease is less deadly, but far more contagious than previously recognized. If these numbers are correct, the true numbers of cases in the US would be close to 25,000,000.
Large autopsy study of COVID-19 patients concludes infection is almost exclusively limited to the lungs. Detailed autopsy studies of 41 consecutive COVID-19 fatalities found "massive presence" of viral RNA in the lungs with extensive damage to the alveoli along with widespread thrombi (blood clots) in the small and large vessels of the lungs. There were limited signs of infection in the heart and no evidence of the viral infection in kidney, liver, or brain. Damage to those organs appears to be the combined result of the age of the patients and hypoxia related to COVID-19 lung injury. It should be noted that not all organ systems were examined in all patients, but the reasons for this were not discussed. This raises the possibility of bias in the study results. In addition, these results appear to be at odds with the two studies below describing injury to the pancreas and brain.
New onset diabetes is frequently associated with critically ill COVID-19 patients A retrospective study of 120 patients in China found that 54% of critically ill patients with no history of diabetes and no treatment with steroids had fasting blood glucose levels consistent with diabetes, almost four times the rate seen in moderately to severely ill patients. The authors conclude this is an indicator of multi-organ injury, including infection of pancreatic islet cells, and should be used as an indicator of risk in hospitalized patients.
SARS-CoV-2 replicates in neurons and in the brains of mice A team of investigators at Yale demonstrated that the virus can infect neuronal cells in culture, replicate in those cells and cause the death of surrounding neurons. When the virus was injected into the cerebral ventricles of mice at just 1% of the concentration necessary to infect the lungs with intranasal injection, the virus caused severe brain injury and death. This suggests that SARS-CoV-2 infection of the brain has the potential to cause serious brain injury and even death.
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Unless otherwise noted, these pre-prints are not peer reviewed.
Related Posts in Covid19- Ahead of the Curve.
Peer review, the press, and seroprevalence misinformation Two months ago, three studies delivered startling information about the prevalence of antibodies to SARS-CoV-2 and the percent of infections that are asymptomatic, but it was not clear what they meant. They may have taught us more about the flaws inherent in the release of studies in the absence of peer review..
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Clinical Laboratory and Diagnostics
- Evaluation on the diagnostic efficiency of different methods in detecting COVID-19. MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- Nanotrap® particles improve detection of SARS-CoV-2 for pooled sample methods, extraction-free saliva methods, and extraction-free medium methods bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
- Resource optimization in COVID-19 diagnosis bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
Emergency Care and Triage
- Hypoferremia predicts hospitalization and oxygen demand in COVID-19 patients MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- A Multi-Task Pipeline with Specialized Streams for Classification and Segmentation of Infection Manifestations in COVID-19 Scans MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- Accommodating individual travel history, global mobility, and unsampled diversity in phylogeography: a SARS-CoV-2 case study bioRxiv: The Preprint Server for Biology (Covid), June 26, 2020
- Hospital-based autonomous pre-clinical screening of COVID-19: An emergency triage using a vital signs recording system, Paris-Ile de France region. MedRxiv Server for Health Sciences: Coronavirus, June 25, 2020
Infection Control
- Air and surface measurements of SARS-CoV-2 inside a bus during normal operation bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
- Ag nanoparticles-based antimicrobial polycotton fabrics to prevent the transmission and spread of SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
- The Effect of Ultraviolet C Radiation Against SARS-CoV-2 Inoculated N95 Respirators MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
Clinical Course and Outcomes
- Meningoencephalitis associated with COVID-19: A systematic review MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- Clinical course and potential predicting factors of pneumonia of adult patients with coronavirus disease 2019 (COVID-19): A retrospective observational analysis of 193 confirmed cases in Thailand MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- A Systematic Review and Meta-analysis of D-Dimer Levels in Patients Hospitalized with Coronavirus Disease 2019 (COVID-19) MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
Impact on Other Specialties
- Assessment of respiratory droplet transmission during the ophthalmic slit lamp exam: a particle tracking analysis MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- Evaluating aerosol and splatter following dental procedures bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
Reviews, Commentary, and Miscellaneous
- Modelling strategies to organize healthcare workforce during pandemics: application to COVID-19 MedRxiv Server for Health Sciences: Coronavirus, June 25, 2020
- Timeline from receipt to online publication of COVID-19 original research articles MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- An analysis of COVID-19 article dissemination by Twitter compared to citation rates MedRxiv Server for Health Sciences: Coronavirus, June 25, 2020
Mental Health
- Uncertainty stress, and its impact on disease fear and prevention behaviors during the COVID-19 epidemic in China: A panel study MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- IMPACT OF COVID-19 PANDEMIC ON MENTAL HEALTH OF MEDICAL STUDENTS:A CROSS-SECTIONAL STUDY USING GAD-7 AND PHQ-9 QUESTIONNAIRES MedRxiv Server for Health Sciences: Coronavirus, June 25, 2020
- The psychological effects of quarantine during COVID-19 outbreak: Sentiment analysis of social media data MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
Drug Development
- Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2 bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
- Ionophore antibiotic X-206 is a potent and selective inhibitor of SARS-CoV-2 infection bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
- COVID-19-associated ARDS treated with DEXamethasone (CoDEX): Study design and rationale for a randomized trial. MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
Newly Registered Clinical Trials
- Emergence of the COVID 19 Epidemic in the City of Nice June 26, 2020
- The PAWS-COVID-19 (Pediatric AirWay complicationS COVID-19) Registry June 26, 2020
- Mechanisms for Covid-19 Disease Complications June 26, 2020
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BASIC SCIENCE AND EPIDEMIOLOGY
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Virology, Immunology, and Pathophysiology
- Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
- Development of a Coronavirus Disease 2019 Nonhuman Primate Model Using Airborne Exposure bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
- In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
Epidemiology
- COVID-19 Confirmed Cases and Fatalities in 883 U.S. Counties with a Population of 50,000 or More: Predictions Based on Social, Economic, Demographic Factors and Shutdown Days MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- Chasing the origin of SARS-CoV-2 in Canada’s COVID-19 cases: A genomics study bioRxiv: The Preprint Server for Biology (Covid), June 27, 2020
- Reproduction ratio and growth rates: measures for an unfolding pandemic MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
Modeling and Prediction
- Covid-19 Pandemic Data Analysis and Forecasting using Machine Learning Algorithms MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- A Metapopulation Network Model for the Spreading of SARS-CoV-2: Case Study for Ireland MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- A Logistic Curve in the SIR Model and Its Application to Deaths by COVID-19 in Japan MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
Public Health Intervention
- Neighborhood income and physical distancing during the COVID-19 pandemic in the U.S. MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- Short-term forecasts and long-term mitigation evaluations for the COVID-19 epidemic in Hubei Province, China MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- Predictable county-level estimates of R0 for COVID-19 needed for public health planning in the USA MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
Surveillance and sero-epidemiology
- Evaluation of two commercial and two non-commercial immunoassays for the detection of prior infection to SARS-CoV-2 MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2 MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- A cross-sectional study of immune seroconversion to SARS-CoV-2 in front-line maternity health professionals MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
Published Literature
- New report shows COVID-19 increasing in Puget Sound and across state Washington State Department of Health: Coronavirus, June 27, 2020
- COVID-19 in Immunocompromised Hosts: What We Know So Far Infectious Diseases Society of America Journals: Coronavirus, June 27, 2020
- Positive SARS-CoV-2 RNA recurs repeatedly in a case recovered from COVID-19: dynamic results from 108 days of follow-up Oxford Academic Journals: Coronavirus, June 27, 2020
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Coronavirus Research Resources
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China
- Short-term forecasts and long-term mitigation evaluations for the COVID-19 epidemic in Hubei Province, China MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- Uncertainty stress, and its impact on disease fear and prevention behaviors during the COVID-19 epidemic in China: A panel study MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- Epidemiological and clinical characteristics of 671 COVID-19 patients in Henan Province, China Oxford Academic Journals: Coronavirus, June 26, 2020
- Prevention and infection control of COVID-19 in Nursing Homes: experience from China Oxford Academic Journals: Coronavirus, June 25, 2020
Italy
- SARS-CoV-2 has been circulating in northern Italy since December 2019: evidence from environmental monitoring MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- Exploring Causal relationship between risk factors and vulnerability to COVID-19 Cases of Italy, Spain, France, Greece, Portugal, Morocco and South Africa MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- Qualitative forecast and temporal evolution of the disease spreading using a simplified model and COVID-19 data for Italy MedRxiv Server for Health Sciences: Coronavirus, June 25, 2020
Spain
- Exploring Causal relationship between risk factors and vulnerability to COVID-19 Cases of Italy, Spain, France, Greece, Portugal, Morocco and South Africa MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- Seroprevalence of SARS-CoV-2 IgG Specific Antibodies among Healthcare Workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
Germany
- Germany And France Promise New Financial Support To World Health Organization NPR: Health, June 25, 2020
France
- Modelling lockdown-induced second COVID waves in France MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- Exploring Causal relationship between risk factors and vulnerability to COVID-19 Cases of Italy, Spain, France, Greece, Portugal, Morocco and South Africa MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
- Hospital-based autonomous pre-clinical screening of COVID-19: An emergency triage using a vital signs recording system, Paris-Ile de France region. MedRxiv Server for Health Sciences: Coronavirus, June 25, 2020
- Liberté, Egalité, Fraternité... Contaminé? Estimating the impact of French municipal elections on COVID-19 spread in France MedRxiv Server for Health Sciences: Coronavirus, June 25, 2020
- Germany And France Promise New Financial Support To World Health Organization NPR: Health, June 25, 2020
United Kingdom
- A geotemporal survey of hospital bed saturation across England during the first wave of the COVID-19 Pandemic MedRxiv Server for Health Sciences: Coronavirus, June 25, 2020
Other International News
- A Metapopulation Network Model for the Spreading of SARS-CoV-2: Case Study for Ireland MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- A Logistic Curve in the SIR Model and Its Application to Deaths by COVID-19 in Japan MedRxiv Server for Health Sciences: Coronavirus, June 27, 2020
- Mathematical modeling of the COVID-19 prevalence in Saudi Arabia MedRxiv Server for Health Sciences: Coronavirus, June 26, 2020
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Business and Economic News
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Business News
- 12 states are pausing reopening over the surge in US coronavirus cases CNN.com - Health, June 27, 2020
- After saving his own life with a repurposed drug, a professor reviews every drug being tried against Covid-19. Here's what he's found CNN.com - Health, June 27, 2020
- Science by press release: When the story gets ahead of the science CNN.com - Health, June 27, 2020
Economics Blogs
- The world’s poor cannot protect themselves well from the novel coronavirus VoxEU.org, June 27, 2020
- Coronavirus Causes Weaponized 'Tentacles' To Sprout From Infected Cells, Directly Inject Virus Into New Ones Zero Hedge, June 26, 2020
- Stocks & Bond Yields Plunge On COVID Surge & Fed Balance Sheet Purge Zero Hedge, June 26, 2020
Top Economics News
- Florida sets new record in daily coronavirus cases: Live updates - Al Jazeera English (Colombian Economy), June 27, 2020
- To counter the downtrodden economy, Trump exaggerates its pre-coronavirus greatness - The Boston Globe (Trump Economy), June 27, 2020
- Barbados' foreign reserves remain strong despite hard COVID-19 hit - Loop News Barbados (Carribean Economy), June 27, 2020
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Law Technology
- 5 things you should do right now to fight the rising number of COVID-19 cases LLRX.com, June 27, 2020
- Public Relations and COVID-19: Studies Surface Challenges, Changes and Optimism Sword and the Script, June 27, 2020
- Bloomberg: Coronavirus Tests the Limits of America’s Public Libraries Stephen's Lighthouse, June 27, 2020
Legal Administrator
- Flattening the Curve: State COVID-19 Immunity Initiatives Help Suppress a Surge in New Class Action Litigation Blog of Legal Times, June 26, 2020
- Berkeley Law Announces Fully Remote Fall Due to COVID-19 Blog of Legal Times, June 26, 2020
- David Shulman's "The Post-COVID Economy" Law and More, June 26, 2020
Librarian News
- Lexology Ariticle: COVID-19: Law Society’s guidance on the use of virtual execution and e-signatures House of Butter, June 27, 2020
- USA: State Bar Association Tables Vote on Mandatory COVID-19 Vaccinations House of Butter, June 27, 2020
- 5 things you should do right now to fight the rising number of COVID-19 cases LLRX.com, June 27, 2020
Leading Law Departments
- Post-COVID Business Practicalities: Better Policy, EUC and Model Risk Management Mitratech: Press Releases, June 26, 2020
- How to find mentors & sponsors during the COVID-19 era Legal Executive Institute: Blog, June 26, 2020
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 | | Robert Morris, MD, PhD, Editor
Dr. Robert Morris is an epidemiologist and award-winning author who has taught epidemiology at Tufts and Harvard and has advised the CDC, the EPA, NIH, and the President's Cancer Panel. |
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